WNT10B Protein, wingless-type MMTV integration site family, member 10B

WNT10B

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WNT10B

Official Full Name wingless-type MMTV integration site family, member 10B
Background The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.
Synonyms WNT10B; wingless-type MMTV integration site family, member 10B; protein Wnt-10b; SHFM6; WNT 12; WNT-10B protein; WNT-12
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human WNT10B-1494H Recombinant Human WNT10B protein, His & T7-tagged E.coli His/T7
    Human WNT10B-302HCL Recombinant Human WNT10B 293 Cell Lysate HEK293 N/A
    Human WNT10B-534H Recombinant Human WNT10B CHO N/A
    Mouse WNT10B-18565M Recombinant Mouse WNT10B Protein Mammalian Cell His
    Mouse Wnt10b-664M Recombinant Mouse Wnt10b CHO N/A
    Rhesus Macaque WNT10B-5217R Recombinant Rhesus monkey WNT10B Protein, His-tagged Mammalian Cell His
    Zebrafish WNT10B-9579Z Recombinant Zebrafish WNT10B Mammalian Cell His

    WNT10B involved in several pathways and played different roles in them. We selected most pathways WNT10B participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT10B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway SFRP4; FZD8; MAP3K7; FZD1; TBL1Y; SIAH1A; CCND2; SFRP5; SKP1; FBXW2
    Hedgehog signaling pathway RAB23; CSNK1DB; WNT5A; WNT2BA; DYRK1A; GSK3AA; GAS1B; FBXW11; CSNK1G3; CSNK1G2B
    Hippo signaling pathway GDF5; TGFBR2; LLGL1; WTIP; INADL; GSK3B; APC2; WNT1; PPP2CB; BMP5
    Signaling pathways regulating pluripotency of stem cells ACVR2A; MAPK11; WNT7B; WNT8A; BMPR1B; SMAD2; SMAD1; FZD7; MAP2K1; NEUROG1
    Melanogenesis WNT9B; WNT2BB; EP300; PRKACA; KITA; PRKCG; WNT9A; FZD5; POMC; CAMK2D1
    HTLV-I infection PDGFRB; WNT5A; ANAPC7; ATF3; HLA-B; WNT9A; APC; TBP; CCNB2; ITGAL
    Pathways in cancer WNT7A; RARB; FGF5; Fzd4; NFKB2; TRAF5; TPR; PIK3R2; IKBKB; RBX1
    Proteoglycans in cancer TLR2; PPP1R12C; HGF; VEGFA; Ctsl; HIF1A; HPSE2; ARAF; FZD2; PRKACB
    Basal cell carcinoma WNT3; APC; AXIN2; FZD9; PTCH2; WNT6; GLI3; WNT2B; DVL1; FZD5

    WNT10B has several biochemical functions, for example, frizzled binding, receptor agonist activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT10B itself. We selected most functions WNT10B had, and list some proteins which have the same functions with WNT10B. You can find most of the proteins on our site.

    Function Related Protein
    frizzled binding FZD7; WNT11; WNT7AA; RSPO3; WNT1; WNT4B; WNT9B; RNF43; WNT8A; MYOC
    receptor agonist activity NODAL; WNT1; WNT4; SFRP2; WNT7A; GREM1; WNT2; CXCL13; VEGFA; WNT5A

    WNT10B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT10B here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT10B.

    Tyagi, AM; Mansoori, MN; et al. Enhanced Immunoprotective Effects by Anti-IL-17 Antibody Translates to Improved Skeletal Parameters Under Estrogen Deficiency Compared With Anti-RANKL and Anti-TNF-alpha Antibodies. JOURNAL OF BONE AND MINERAL RESEARCH 29:1981-1992(2014).
    Li, JY; Walker, LD; et al. The Sclerostin-Independent Bone Anabolic Activity of Intermittent PTH Treatment Is Mediated by T-Cell-Produced Wnt10b. JOURNAL OF BONE AND MINERAL RESEARCH 29:43-54(2014).

    WNT

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