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XPO1

  • Official Full Name

    exportin 1

  • Overview

    The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008]
  • Synonyms

    XPO1; exportin 1; emb; CRM1; exp1; exportin-1; CRM1, yeast, homolog; exportin 1 (CRM1 homolog, yeast); chromosome region maintenance 1 homolog; chromosome region maintenance 1 protein homolog; exportin-1 (required for chromosome region maintenance);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human XPO1-3754H Recombinant Human XPO1, GST-tagged Wheat Germ GST
Human XPO1-3753H Recombinant Human XPO1, GST-tagged E.coli GST N-term-302aa
Human XPO1-259HCL Recombinant Human XPO1 293 Cell Lysate HEK293 N/A
Human XPO1-5164H Recombinant Human XPO1 Protein (Thr917-Asp1071), His tagged E.coli His Thr917-Asp1071
Human XPO1-460H Recombinant Human XPO1 Protein, His-tagged E.coli His Thr917~Asp1071
Human XPO1-551HF Recombinant Full Length Human XPO1 Protein, GST-tagged In Vitro Cell Free System GST 1071 amino acids
Human XPO1-3796H Recombinant Human XPO1 protein, His-tagged E.coli His 301-540 aa
Rat XPO1-6619R Recombinant Rat XPO1 Protein Mammalian Cell His
Rat XPO1-6275R-B Recombinant Rat XPO1 Protein Pre-coupled Magnetic Beads HEK293
Rat XPO1-6275R Recombinant Rat XPO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque XPO1-5230R Recombinant Rhesus monkey XPO1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque XPO1-5043R-B Recombinant Rhesus Macaque XPO1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque XPO1-5043R Recombinant Rhesus Macaque XPO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken XPO1-2087C Recombinant Chicken XPO1 Mammalian Cell His
Chicken XPO1-5491C Recombinant Chicken XPO1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

XPO1 involved in several pathways and played different roles in them. We selected most pathways XPO1 participated on our site, such as Ribosome biogenesis in eukaryotes, RNA transport, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ribosome biogenesis in eukaryotesFCF1;WDR36;NXF2;NOP10;TBL3;RPP40;IMP3;XPO1;RPP38
RNA transportRPP25L;EIF4E2RS1;RPP40;NUP160;POP4;WIBG;GEMIN8;EIF3HB;ELAC1
Influenza ACPSF4;TBK1;AKT1;IRAK4;RELA;HLA-DOB;MAP2K6;NXF1;TYK2
HTLV-I infectionIL1R2;H2-AB1;VDAC1;HLA-E;TGFBR1;ANAPC11;VCAM1;WNT8A;WNT9A
Epstein-Barr virus infectionHDAC2;CD40;HLA-A;HLA-DPB1;POLR3H;GTF2E1;PRKACB;STAT3;GTF2B

XPO1 has several biochemical functions, for example, RNA binding, Ran GTPase binding, nucleocytoplasmic transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XPO1 itself. We selected most functions XPO1 had, and list some proteins which have the same functions with XPO1. You can find most of the proteins on our site.

Function Related Protein
RNA bindingCPSF3;RBM3;APOBEC1;SRP14;PPP5C;TDRKH;NSUN6;SRSF10;AGO1
Ran GTPase bindingKPNB1;IPO7;RANGAP1;IPO9;NXT1;IPO8;RANBP1;XPOT;IPO11
nucleocytoplasmic transporter activityNUP160;NUP214;TPR;NUP153;NUPL1;RBM22;XPO1;NUP54;NUP107
protein bindingCHD2;MPPE1;NCAPD2;GNB2L1;SCO2;PTPRR;PODXL2;SUB1;NPDC1
protein domain specific bindingEHD2;UNC13A;STX18;FOXA3;HIST2H4A;RQCD1;CENPJ;CALM2;GUSB
protein transporter activityPGAP2;CALCR;AP2A2;TNPO2;ARFGAP3;RUFY1;DSCR3;TMCO6;ZFYVE16
transporter activitySLC6A18;DYF-1;SLC4A1B;CRABP1A;IGF2R;SLC5A11;LCN5;SLC2A11L;MIP

XPO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XPO1.

YWHAZ; VCAM1; BIRC5; vpu; TGS1; HAX1; ERBB2; TP53; RCC1

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