XPO1
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Official Full Name
exportin 1
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Overview
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008] -
Synonyms
XPO1; exportin 1; emb; CRM1; exp1; exportin-1; CRM1, yeast, homolog; exportin 1 (CRM1 homolog, yeast); chromosome region maintenance 1 homolog; chromosome region maintenance 1 protein homolog; exportin-1 (required for chromosome region maintenance);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | XPO1-3754H | Recombinant Human XPO1, GST-tagged | Wheat Germ | GST | ||
Human | XPO1-3753H | Recombinant Human XPO1, GST-tagged | E.coli | GST | N-term-302aa | |
Human | XPO1-259HCL | Recombinant Human XPO1 293 Cell Lysate | HEK293 | N/A | ||
Human | XPO1-5164H | Recombinant Human XPO1 Protein (Thr917-Asp1071), His tagged | E.coli | His | Thr917-Asp1071 | |
Human | XPO1-460H | Recombinant Human XPO1 Protein, His-tagged | E.coli | His | Thr917~Asp1071 | |
Human | XPO1-551HF | Recombinant Full Length Human XPO1 Protein, GST-tagged | In Vitro Cell Free System | GST | 1071 amino acids | |
Human | XPO1-3796H | Recombinant Human XPO1 protein, His-tagged | E.coli | His | 301-540 aa | |
Rat | XPO1-6619R | Recombinant Rat XPO1 Protein | Mammalian Cell | His | ||
Rat | XPO1-6275R-B | Recombinant Rat XPO1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | XPO1-6275R | Recombinant Rat XPO1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | XPO1-5230R | Recombinant Rhesus monkey XPO1 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | XPO1-5043R-B | Recombinant Rhesus Macaque XPO1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | XPO1-5043R | Recombinant Rhesus Macaque XPO1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Chicken | XPO1-2087C | Recombinant Chicken XPO1 | Mammalian Cell | His | ||
Chicken | XPO1-5491C | Recombinant Chicken XPO1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
XPO1 involved in several pathways and played different roles in them. We selected most pathways XPO1 participated on our site, such as Ribosome biogenesis in eukaryotes, RNA transport, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ribosome biogenesis in eukaryotes | FCF1;WDR36;NXF2;NOP10;TBL3;RPP40;IMP3;XPO1;RPP38 |
RNA transport | RPP25L;EIF4E2RS1;RPP40;NUP160;POP4;WIBG;GEMIN8;EIF3HB;ELAC1 |
Influenza A | CPSF4;TBK1;AKT1;IRAK4;RELA;HLA-DOB;MAP2K6;NXF1;TYK2 |
HTLV-I infection | IL1R2;H2-AB1;VDAC1;HLA-E;TGFBR1;ANAPC11;VCAM1;WNT8A;WNT9A |
Epstein-Barr virus infection | HDAC2;CD40;HLA-A;HLA-DPB1;POLR3H;GTF2E1;PRKACB;STAT3;GTF2B |
XPO1 has several biochemical functions, for example, RNA binding, Ran GTPase binding, nucleocytoplasmic transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XPO1 itself. We selected most functions XPO1 had, and list some proteins which have the same functions with XPO1. You can find most of the proteins on our site.
Function | Related Protein |
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RNA binding | CPSF3;RBM3;APOBEC1;SRP14;PPP5C;TDRKH;NSUN6;SRSF10;AGO1 |
Ran GTPase binding | KPNB1;IPO7;RANGAP1;IPO9;NXT1;IPO8;RANBP1;XPOT;IPO11 |
nucleocytoplasmic transporter activity | NUP160;NUP214;TPR;NUP153;NUPL1;RBM22;XPO1;NUP54;NUP107 |
protein binding | CHD2;MPPE1;NCAPD2;GNB2L1;SCO2;PTPRR;PODXL2;SUB1;NPDC1 |
protein domain specific binding | EHD2;UNC13A;STX18;FOXA3;HIST2H4A;RQCD1;CENPJ;CALM2;GUSB |
protein transporter activity | PGAP2;CALCR;AP2A2;TNPO2;ARFGAP3;RUFY1;DSCR3;TMCO6;ZFYVE16 |
transporter activity | SLC6A18;DYF-1;SLC4A1B;CRABP1A;IGF2R;SLC5A11;LCN5;SLC2A11L;MIP |
XPO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XPO1.
YWHAZ; VCAM1; BIRC5; vpu; TGS1; HAX1; ERBB2; TP53; RCC1
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