XPO1 Protein, exportin 1


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Official Full Name exportin 1
Background The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008]
Synonyms XPO1; exportin 1; emb; CRM1; exp1; exportin-1; CRM1, yeast, homolog; exportin 1 (CRM1 homolog, yeast); chromosome region maintenance 1 homolog; chromosome region maintenance 1 protein homolog; exportin-1 (required for chromosome region maintenance);
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human XPO1-259HCL Recombinant Human XPO1 293 Cell Lysate HEK293 N/A
    Human XPO1-3753H Recombinant Human XPO1, GST-tagged E.coli GST
    Human XPO1-3754H Recombinant Human XPO1, GST-tagged Wheat Germ GST
    Human XPO1-460H Recombinant Human XPO1 Protein, His-tagged E.coli His
    Rat XPO1-6619R Recombinant Rat XPO1 Protein Mammalian Cell His
    Rhesus Macaque XPO1-5230R Recombinant Rhesus monkey XPO1 Protein, His-tagged Mammalian Cell His
    Chicken XPO1-2087C Recombinant Chicken XPO1 Mammalian Cell His
    Chicken XPO1-5491C Recombinant Chicken XPO1 Mammalian Cell His

    XPO1 involved in several pathways and played different roles in them. We selected most pathways XPO1 participated on our site, such as Ribosome biogenesis in eukaryotes, RNA transport, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ribosome biogenesis in eukaryotes IMP3; CSNK2A2A; WDR36; ACK2; REXO2; UTP14C; UTP15; XRN1; GNL3L; CIRH1A
    Influenza A PIK3R2; CASP1; MAP2K7; PRKCB; DDX39B; KPNA2; AKT2; IFNA12; PIK3R5; TLR7
    HTLV-I infection CD3E; SFPI1; PDGFB; H2-AB1; TCF3; PRKACA; WNT1; SLC25A31; DVL2; VDAC3
    Epstein-Barr virus infection POLR2C; MAPK9; CD44; AKAP8L; TP53; YWHAH; CDK1; TAB2; AKT2; CD40

    XPO1 has several biochemical functions, for example, RNA binding, Ran GTPase binding, nucleocytoplasmic transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XPO1 itself. We selected most functions XPO1 had, and list some proteins which have the same functions with XPO1. You can find most of the proteins on our site.

    Function Related Protein
    Ran GTPase binding RANBP2; NUTF2; TNPO1; NUP153; TNPO2; XPO6; BIRC5; IPO13; XPO1; IPO11
    nucleocytoplasmic transporter activity NUP153; NUP214; XPO1; NUP35; NUP133; TPR; NUP160; UPF3A; NUP107; NUPL1
    protein binding YWHAE; GMCL1; C2orf51; CAP2; PAX9; CNST; FAH; CCT4; WDR61; TEF
    protein domain specific binding SFN; FOXH1; ARFIP2A; ACSL3; RAPGEF3; CHMP2B; LIN7B; TH; E2F4; RAB27A
    protein transporter activity KPNA3; EIF4ENIF1; TIMM10; IPO13; IPO11; AP1S3A; AP1G1; AP1G2; AP2A1; ARFGAP3
    transporter activity SLC13A1; TMEM184B; SLC15A2; SLC25A31; AQP3A; AQP10B; ATP5J; CLVS2; MFSD9; LCN5

    XPO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XPO1.

    YWHAZ; VCAM1; BIRC5; vpu; TGS1; HAX1; ERBB2; TP53; RCC1

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