This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.
ZMPSTE24 involved in several pathways and played different roles in them. We selected most pathways ZMPSTE24 participated on our site, such as Terpenoid backbone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZMPSTE24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
ZMPSTE24 has several biochemical functions, for example, metalloendopeptidase activity, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ZMPSTE24 itself. We selected most functions ZMPSTE24 had, and list some proteins which have the same functions with ZMPSTE24. You can find most of the proteins on our site.
Function metalloendopeptidase activity
Related Protein ADAMTSL4; OSGEPL1; PHEX; SPG7; MMP20; MMP23B; ADAMTS4; C6AST4; ADAMTS1; YME1L1B
Function peptidase activity
Related Protein USP27X; TMPRSS5; OTUD4; LTA4H; GM5077; TPP1; KLK1B8; DUB1; CTSB; PSMB11