znf473
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  • Official Full Name
  • zinc finger protein 473
  • Background
  • Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.
  • Synonyms
  • ZNF473; zinc finger protein 473; ZN473; HZFP100; zfp-100; zinc finger protein ZFP100; zinc finger protein 100 homolog; Zfp 100; ZNF 473; 4932441F21; D030014N22Rik
Cat.#:ZNF473-582HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ZNF473 Protein, His-tagged
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Cat.#:ZFP473-18953MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ZFP473 Protein
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Cat.#:ZNF473-5333RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ZNF473 Protein, His-tagged
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Cat.#:ZNF473-2033HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ZNF473 cell lysate
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Involved Pathway

ZNF473 involved in several pathways and played different roles in them. We selected most pathways ZNF473 participated on our site, such as Cleavage of Growing Transcript in the Termination Region, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZNF473 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cleavage of Growing Transcript in the Termination Region
SRSF11; THOC4; ZNF473; LSM11; CLP1; ZFP473; CSTF2; SLBP; CSTF1; RNPS1
Gene Expression
EARS2; HNRNPL2; EIF5; HUG; TRMT1; C2orf29; ZNF625; TRMT44; ZNF496; ZNF785
Generic Transcription Pathway
COX5B; ZNF718; ZNF680; RXRBB; ZNF668; ZNF483; COX6B1; GLS2B; ESRRA; ZNF729
Processing of Capped Intronless Pre-mRNA
LSM10; SLBP; CLP1; PAPOLA; CSTF2; ZNF473; NUDT21; LSM11; ZFP473; CSTF3
RNA Polymerase II Transcription
U2AF2; CSTF1; ZNF473; SRSF11; CSTF3; LSM10; GM3258; THOC4; SUPT16H; CCNT2A
RNA Polymerase II Transcription Termination
RNPS1; CSTF3; ZFP473; SLBP; LSM10; SRSF11; PAPOLA; U2AF2; ZNF473; NUDT21
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
ZFP473; SLBP; ZNF473; LSM10; LSM11
SLBP independent Processing of Histone Pre-mRNAs
LSM11; ZNF473; LSM10; ZFP473

Protein Function

ZNF473 has several biochemical functions, for example, DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZNF473 itself. We selected most functions ZNF473 had, and list some proteins which have the same functions with ZNF473. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF596; GPBP1; ZFP746; POLR2B; ARHGAP35; PBX1B; PC; ZNF785; LBX1A; PROX1
Function metal ion binding
Related Protein ACAT1; ALDH1A2; PRDM12B; CACNA2D1; SGSH; ZNF362A; ATP2B2; GNA15; ZBTB26; OAS2
Function protein binding
Related Protein NMI; TMEM174; PYURF; AAK1; DDX23; PEX11B; SPATA8; PENK; PATL1; APP

Interacting Protein

ZNF473 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZNF473 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZNF473.
RNPS1; ZSCAN12; ZNF250; CLK2; KRTAP10-8; KRTAP10-9; ZNF792

ZNF473 Related Articles

Hu, C; Zhang, SP; et al. Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. JOURNAL OF BIOLOGICAL CHEMISTRY 287:18937-18952(2012).
White, D; Rafalska-Metcalf, IU; et al. The ATM Substrate KAP1 Controls DNA Repair in Heterochromatin: Regulation by HP1 Proteins and Serine 473/824 Phosphorylation. MOLECULAR CANCER RESEARCH 10:401-414(2012).