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ABCA12

  • Official Full Name

    ATP-binding cassette, sub-family A (ABC1), member 12

  • Overview

    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants.
  • Synonyms

    ABCA12; ATP-binding cassette, sub-family A (ABC1), member 12; ichthyosis congenita II, lamellar ichthyosis B , ICR2B; ATP-binding cassette sub-family A member 12; DKFZP434G232; LI2; ATP-binding cassette transporter 12; ICR2B; FLJ41584;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABCA12-7853H Recombinant Human ABCA12 protein, His & T7-tagged E.coli His/T7 Val1346~Thr1577 (Accession # Q86UK0)
  • ABCA12 Related Articles

ABCA12 involved in several pathways and played different roles in them. We selected most pathways ABCA12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ABCA12 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA12 itself. We selected most functions ABCA12 had, and list some proteins which have the same functions with ABCA12. You can find most of the proteins on our site.

Function Related Protein

ABCA12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA12.

Haller, JF; Cavallaro, P; et al. Endogenous beta-glucocerebrosidase activity in Abca12(-/-) epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. JOURNAL OF LIPID RESEARCH 55:493-503(2014).
Sakai, K; Akiyama, M; et al. Localization of ABCA12 from Golgi apparatus to lamellar granules in human upper epidermal keratinocytes. EXPERIMENTAL DERMATOLOGY 16:920-926(2007).
Stahlman, MT; Besnard, V; et al. Expression of ABCA3 in developing lung and other tissues. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 55:71-83(2007).
  • Q&As
  • Reviews

Q&As (8)

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What does the ABCA12 protein, a member of the transporter family ABC, mainly transports? 04/14/2023

ABCA12 mainly transports lipids such as ceramides.

I am engaged in research related to pancreatic cancer, is this ABCA12 protein applicable to my research? 04/14/2023

ABCA12 protein is involved in the regulation of insulin secreted by pancreatic islet B cells, and is highly expressed in pancreatic cancer tissues and cells, so choosing recombinant ABCA12 protein may help your research advance.

I am using ABCA12 for western blot, how long should I incubate the primary antibody at 4°C? 04/14/2023

Generally, incubate overnight at 4 °C.

Which activators will affect the expression of ABCA12 protein? 04/14/2023

PPAR and LXR activators increase ABCA12 protein expression.

I am doing research on skin diseases, is this ABCA1 protein product suitable? 04/14/2023

ABCA12 is a keratinocyte transmembrane lipid transporter, and the lipid transport by ABCA12 is associated with the intact differentiation of keratinocytes.

I only need to buy a small amount of ABCA12 protein. I wonder if this is a large-scale product? 04/14/2023

We provide products with different specifications, put forward your needs through the inquiry form, and we will provide you with product specifications and price information.

How to deal with the ABCA12 recombinant protein in lyophilized powder state before use? 04/14/2023

Add sterile water as a reconstitution agent, shake gently, and then blow gently with a pipettor several times to dissolve completely. Avoid rapid shaking or violent shaking during the dissolution process.

Can you provide His-tagged ABCA12 recombinant protein? 04/14/2023

If you have special tag type requirements, please contact us, and we can provide customized recombinant protein products according to your needs.

Customer Reviews (3)

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Reviews
02/26/2022

    The quality of the recombinant protein met the requirements, and the after-sales technical service also gave me some help related to experiments.

    06/18/2021

      The recombinant ABCA12 protein I purchased works fine for western blots.

      11/05/2019

        The delivery was fast and the protein purity was as required.

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