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ABCA8

  • Official Full Name

    ATP-binding cassette, sub-family A (ABC1), member 8

  • Overview

    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The function of this protein has not yet been determined.
  • Synonyms

    ABCA8; ATP-binding cassette, sub-family A (ABC1), member 8; ATP-binding cassette sub-family A member 8; KIAA0822; MGC163152;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABCA8-3730H Recombinant Human ABCA8, His-tagged E.Coli or Yeast His 1581
Human ABCA8-036H Recombinant Human ABCA8 Protein, GST-Tagged Wheat Germ GST
Human ABCA8-8141H Recombinant Human ABCA8 protein, His & T7-tagged E.coli His/T7 Lys1263~Leu1456 (Accession # O94911)
Human ABCA8-754HF Recombinant Full Length Human ABCA8 Protein, GST-tagged In Vitro Cell Free System GST 266 amino acids
Rat Abca8-8143R Recombinant Rat Abca8 protein, His & T7-tagged E.coli His/T7 Ala1305~Glu1516 (Accession # D3ZAE9)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ABCA8 Related Articles

ABCA8 involved in several pathways and played different roles in them. We selected most pathways ABCA8 participated on our site, such as ABC transporters, ABC-family proteins mediated transport, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ABC transportersABCA5;ABCB3L1;ABCC6;ABCB5;ABCG2;TAP1;ABCC4;ABCA9;ABCB1LB
ABC-family proteins mediated transportABCG4B;EIF2S3;CFTR;ABCE1;ABCA4A;KCNJ11;ABCA7;ABCC2;EIF2S1A
Transmembrane transport of small moleculesNIPAL3;SLC29A4;SLC1A2A;HTR3C;TRPC4APB;AQP11;SLC29A2;SLC46A1;SLC6A11

ABCA8 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA8 itself. We selected most functions ABCA8 had, and list some proteins which have the same functions with ABCA8. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTIMM44;HARS;RAF1B;PSMC1;C10orf2;PSMC5;RECQL4;ABCF2A;STK32B
ATPase activity, coupled to transmembrane movement of substancesATP6V1D;ABCB1A;ABCD1;TAP1;ABCD2;ABCA4A;ABCB8;ABCC3;ABCA7

ABCA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA8.

Grinberg, M; Stober, RM; et al. Toxicogenomics directory of chemically exposed human hepatocytes. ARCHIVES OF TOXICOLOGY 88:2261-2287(2014).
Hedditch, EL; Gao, B; et al. ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 106:-(2014).
  • Q&As
  • Reviews

Q&As (5)

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What is the purity of these ABCA8 products? 04/14/2023

The purity of each products is different, you can check it on the product details page.

How does ABCA8 affect α-synuclein and p25α? 04/14/2023

Overexpression of ABCA8 in oligodendrocytes caused significant increases in both α-syn and p25α expression. 

Is it related to cancer prognosis? 04/14/2023

Gene product is not prognostic.

Will ABCA8 interact with ABCA1? 04/14/2023

It will. This interaction potentiates cholesterol efflux.

Which pathways are related to ABCA8? 04/14/2023

Among its related pathways are regulation of activated PAK-2p34 by proteasome mediated degradation and transport of inorganic cations/anions and amino acids/oligopeptides.

Customer Reviews (2)

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08/02/2018

    Creative Biomart's after-sales service is very thoughtful and systematic, which makes me feel at ease.

    09/14/2017

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