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ABCB8

  • Official Full Name

    ATP-binding cassette, sub-family B (MDR/TAP), member 8

  • Overview

    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins transport various molecules across extra- and intra-cellular membranes.ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).This protein is a member of the MDR/TAP subfamily.Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation.The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol.This protein may also play a role in the transport of phospholipids into mitochondrial membranes.
  • Synonyms

    ABCB8; ATP-binding cassette, sub-family B (MDR/TAP), member 8; ATP-binding cassette sub-family B member 8, mitochondrial; EST328128; M ABC1; MABC1; mitochondrial ABC protein; mitochondrial ATP-binding cassette 1; M-ABC1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In vitro E. coli expression system
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABCB8-8128H Recombinant Human ABCB8 protein, His & T7-tagged E.coli His/T7 Val472~Ser735 (Accession # Q9NUT2)
Human ABCB8-9151HCL Recombinant Human ABCB8 293 Cell Lysate HEK293 N/A
Human ABCB8-2464H Recombinant Human ABCB8 Transmembrane protein, His-SUMO-tagged In vitro E. coli expression system His-SUMO 38-693aa
Human ABCB8-0158H Recombinant Human ABCB8 Protein (Val472-Ser735), N-His-tagged E.coli N-His Val472-Ser735
Mouse Abcb8-8129M Recombinant Mouse Abcb8 protein, His & T7-tagged E.coli His/T7 Gly468~Ala717 (Accession # Q9CXJ4)
Mouse ABCB8-1095M Recombinant Mouse ABCB8 Protein Mammalian Cell His
Mouse ABCB8-193M-B Recombinant Mouse ABCB8 Protein Pre-coupled Magnetic Beads HEK293
Mouse ABCB8-193M Recombinant Mouse ABCB8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Abcb8-8130R Recombinant Rat Abcb8 protein, His & T7-tagged E.coli His/T7 Gly468~Gln714 (Accession # Q5RKI8)
Rat ABCB8-400R Recombinant Rat ABCB8 Protein Mammalian Cell His
Rat ABCB8-55R-B Recombinant Rat ABCB8 Protein Pre-coupled Magnetic Beads HEK293
Rat ABCB8-55R Recombinant Rat ABCB8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mus musculus (Mouse) RFL35820MF Recombinant Full Length Mouse Atp-Binding Cassette Sub-Family B Member 8, Mitochondrial(Abcb8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (39-717)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL34668PF Recombinant Full Length Pongo Abelii Atp-Binding Cassette Sub-Family B Member 8, Mitochondrial(Abcb8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (39-718)
Rattus norvegicus (Rat) RFL13678RF Recombinant Full Length Rat Atp-Binding Cassette Sub-Family B Member 8, Mitochondrial(Abcb8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (39-714)
Zebrafish ABCB8-2327Z Recombinant Zebrafish ABCB8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ABCB8 Related Articles

ABCB8 involved in several pathways and played different roles in them. We selected most pathways ABCB8 participated on our site, such as ABC transporters, ABC-family proteins mediated transport, Mitochondrial ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ABC transportersABCC1;ABCB4;ABCD2;ABCA13;ABCG1;ABCA3;ABCD3;ABCB9;TAP2
ABC-family proteins mediated transportABCD3B;ABCA7;CFTR;ABCE1;EIF2S1;ABCA8;EIF2S3;ABCB8;APOA1B
Mitochondrial ABC transporters
Transmembrane transport of small moleculesSLC13A1;SCNN1D;SLC39A8;SLC12A4;TRPA1B;FLVCR1;AQP3B;ANO5;SLC34A2A

ABCB8 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCB8 itself. We selected most functions ABCB8 had, and list some proteins which have the same functions with ABCB8. You can find most of the proteins on our site.

Function Related Protein
ATP bindingBRIP1;SIK2;NLRP4;ABCD1;FRK;FYN;DGKB;MAP2K3;CSNK2A2
ATPase activity, coupled to transmembrane movement of substancesABCA3;ABCC2;ABCC11;ABCG2;ABCA7;ABCC3;ABCA8;ABCG3;ABCB7
transporter activityHIATL1;PTGDSB;CPNE3;SLC51B;ABCA1B;ABCB10;AQP9A;ABCA9;SLC4A4A

ABCB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCB8.

SAT1; NOA1

Lin, KM; Chiu, YF; et al. ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment. PHARMACOGENETICS AND GENOMICS 21:163-170(2011).
  • Q&As
  • Reviews

Q&As (12)

Ask a question
Do you offer ABCB8 proteins with other types of tags? 08/15/2022

We provide tag customization services, and you can communicate with us about specific customization needs at any time.

Can ABCB8-2327Z be customized with higher purity protein? 06/04/2022

Yes, we can customize proteins with different purities according to your needs.

Does adding tags affect the activity of ABCB8 protein? 04/11/2022

In general, adding small tags has very little effect on protein activity, but we cannot confirm the specific effect of adding tags on protein activity.

How much is the price of custom-made ABCB8? 02/17/2022

The specific price will vary depending on the customization needs. You can communicate with us about the specific customization needs first, and then we will provide you with price information

ABCB8-2464H has two types of freeze-dried powder and liquid, can you send me the liquid? 01/28/2022

Yes, you put forward this demand when purchasing, and we will deliver according to your demand.

Can the endotoxin level of ABCB8 be customized? 12/07/2021

Yes, we can customize protein products with different endotoxin levels.

Does ABCB8-1095M participate in this promotion? 09/11/2021

Yes, this product is eligible for this promotion.

How is protein purification achieved? 08/27/2021

Our commonly used purification methods include hydrophobic chromatography, affinity chromatography, ion exchange chromatography, salting out, molecular sieve, etc.

I want to buy ABCB8 protein for WB. Can you provide the WB protocol? 03/06/2021

You can make this request when purchasing, and we will send you the relevant protocol.

What is the effect of adding trehalose in storage buffer? 11/14/2020

Trehalose can prevent protein secondary structure changes, elongation and aggregation during freeze-drying.

How long does it take for the product to arrive after purchase? 11/09/2019

After the customer purchases the product, we will ship it as soon as possible, but the arrival time is related to your specific location. If it is a custom-made product, the delivery time will be longer.

I use ABCB8 protein for western blotting, use skim milk to block and incubate the primary antibody at 4°C, how long is the normal incubation time? 04/25/2019

Incubate with the primary antibody overnight at 4°C.

Customer Reviews (2)

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Reviews
04/22/2022

    The technicians are very professional and provided me with some useful suggestions related to experiments.

    09/06/2021

      The customized communication was very smooth, and I also received my customized protein products very quickly.

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