ABCC10
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
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Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ABCC10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; multidrug resistance-associated protein 7; EST182763; MRP7; SIMRP7; ATP-binding cassette sub-family C member 10;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ABCC10-043H | Recombinant Human ABCC10 Protein, GST-Tagged | Wheat Germ | GST |
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| Human | ABCC10-4HCL | Recombinant Human ABCC10 cell lysate | N/A |
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| Human | ABCC10-1534H | Recombinant Human ABCC10 protein, His & T7-tagged | E.coli | His/T7 | Val1246~Pro1492 (Accession # Q5T3U5) |
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| Human | ABCC10-766HF | Recombinant Full Length Human ABCC10 Protein, GST-tagged | In Vitro Cell Free System | GST | 282 amino acids |
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| Mouse | ABCC10-1098M | Recombinant Mouse ABCC10 Protein | Mammalian Cell | His |
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| Mouse | ABCC10-195M-B | Recombinant Mouse ABCC10 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | ABCC10-195M | Recombinant Mouse ABCC10 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
ABCC10 involved in several pathways and played different roles in them. We selected most pathways ABCC10 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCB10;ABCG2;ABCD3A;Abcb1b;ABCA1B;ABCB7;ABCG3;CFTR;ABCD2 |
ABCC10 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC10 itself. We selected most functions ABCC10 had, and list some proteins which have the same functions with ABCC10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CHUK;NOD1;PMVK;DDX17;GUCY2F;TOR2A;TTLL1;AASDH;KIF27 |
| ATPase activity, coupled to transmembrane movement of substances | ABCC11;ABCB3L1;ABCB8;ABCA8;ABCC12;DPY19L2;ABCA9;ABCA6;ABCC3 |
ABCC10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC10 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC10.
- Q&As
- Reviews
Q&As (14)
Ask a questionYes. FTO/YTHDF2/ABCC10 axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance both in vitro and in vivo.
No, the expression of ABCC10 are different in different tumor. The expression of ABCC10 in adenocarcinoma is higher than that in squamous cell carcinoma.
The expression of ABCC10 was mainly located in cell membrane and cytoplasm.
Yes, ABCC10 single-nucleotide polymorphisms (SNPs) are associated with KTD.
CP55 is not the inhibitor, but 5-cyano-6-phenylpyrimidin derivative CP55 was synthesized and found significantly reversal effect of multidrug resistance (MDR) mediated by ABCC10.
ABCC10 Deficiency Prevents Diet-Induced Obesity. Studies have shown that the role of ATP-binding cassette transporter C10 (ABCC10) in regulating lipid metabolism. Furthermore, deletion of ABCC10 ameliorates diet-induced obesity in mice and leads to a better response during insulin and glucose tolerance tests.
Clinical sample analyses indicated that ABCC10 was more highly expressed in Her2+ and ER+ than in Her2-, ER-, and triple-negative breast cancer.
You could construct the drug-resistant stable cell by yourself. We used the paclitaxel-resistant human small cell lung cancer subline to study the resistance to paclitaxe.
Yes. A study concluded that TFV is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence TFV renal tubular transport and contribute to the development of KTD.
ABCC10 is located on the basolateral cell membrane and consists of 3 membrane-spanning domains (MSDs) and 2 nucleotide-binding domains (NBDs).
ABCC10 is a broad-specificity transporter of xenobiotics, including antitumor drugs, such as taxanes, epothilone B, vinca alkaloids, and cytarabine, as well as modulators of the estrogen pathway, such as tamoxifen.
Cepharanthine, lapatinib, erlotinib, nilotinib, imatinib, sildenafil, and vardenafil, have been reported to overcome ABCC10-mediated MDR.
Yes, you could find it on our subsite, please contact us for more information.
You can find the result in "Insights on the structure–function relationship of humanmultidrug resistance protein 7 (MRP7/ABCC10) frommolecular dynamics simulations and docking studies".
Customer Reviews (3)
Write a reviewVery good customer service
Use well in WB
High purity, good quality
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