ABCC13
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Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene
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Overview
This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described. -
Synonyms
ABCC13; ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene; ATP binding cassette, sub family C (CFTR/MRP), member 13; ATP-binding cassette protein C13; C21orf73; PRED6; ATP binding cassette protein C13;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Rhesus Macaque
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | ABCC13-046H | Recombinant Human ABCC13 Protein, GST-Tagged | Wheat Germ | GST |
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| Human | ABCC13-769HF | Recombinant Full Length Human ABCC13 Protein, GST-tagged | In Vitro Cell Free System | GST | 169 amino acids |
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| Homo sapiens (Human) | RFL35687HF | Recombinant Full Length Human Putative Atp-Binding Cassette Sub-Family C Member 13(Abcc13) Protein, His-Tagged | E.coli expression system | His | Full Length (1-274) |
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| Rhesus Macaque | ABCC13-179R | Recombinant Rhesus monkey ABCC13 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | ABCC13-8R-B | Recombinant Rhesus Macaque ABCC13 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rhesus Macaque | ABCC13-8R | Recombinant Rhesus Macaque ABCC13 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- ABCC13 Related Articles
ABCC13 involved in several pathways and played different roles in them. We selected most pathways ABCC13 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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ABCC13 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC13 itself. We selected most functions ABCC13 had, and list some proteins which have the same functions with ABCC13. You can find most of the proteins on our site.
| Function | Related Protein |
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ABCC13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC13 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC13.
- Q&As
- Reviews
Q&As (11)
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Including hist1h2bl, al133243.2, trim58, abcc13, bpgm, and fam210b were identified in the coexpression network
Except for ABCC12/13, the ABCCs were significantly associated with B cell, CD8+ T cell, CD4+ T cell, macrophage, neutrophil, and dendritic cell infiltration
The ABCC13 gene spans approximately 70kb on human chromosome 21q11.2 and consists of 14 exons. The open reading frame of the ABCC13 cDNA encodes a peptide consisting of 325 amino acid residues. The amino acid sequence corresponding to putative membrane-spanning domains was remarkably similar to ABCC1, ABCC2, ABCC3, and ABCC6.
While some studies have investigated the potential of ABCC13 as a biomarker for lung adenocarcinoma, further research is needed to determine its clinical utility and to confirm its specificity and sensitivity as a diagnostic and prognostic marker for this type of cancer.
The ABCC13 gene was expressed in the fetal liver at the highest level among the organs studied. While ABCC13 was expressed in the bone marrow, its expression in peripheral blood leukocytes of adult humans was much lower and no detectable levels were observed in differentiated hematopoietic cells.
ABCC13 shares a similar structure to other MRP transporters, with three TMDs and two NBDs. Although its function is not yet fully characterized, studies suggest that it may be involved in the transport of glutathione and other conjugates.
MRP10/ABCC13 is clearly a pseudo-gene which encodes a truncated protein that is highly expressed in fetal human liver with the highest similarity to MRP2/ABCC2 but without transporting activity.
There is no clear evidence at present that ABCC13 is directly linked to colon cancer.
21q11.2-q21.1
Study data demonstrate that wheat ABCC13 is functionally important for grain development and plays an important role during detoxification of heavy metals.
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Write a reviewThe strip is clear and of high quality
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