Abcg3
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Official Full Name
ATP-binding cassette, subfamily G (WHITE), member 3
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Synonyms
RGD1565568;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Mouse | ABCG3-1116M | Recombinant Mouse ABCG3 Protein | Mammalian Cell | His | ||
Mouse | ABCG3-208M-B | Recombinant Mouse ABCG3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ABCG3-208M | Recombinant Mouse ABCG3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mus musculus (Mouse) | RFL17938MF | Recombinant Full Length Mouse Atp-Binding Cassette Sub-Family G Member 3(Abcg3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-650) |
- Involved Pathway
- Protein Function
- Interacting Protein
Abcg3 involved in several pathways and played different roles in them. We selected most pathways Abcg3 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with Abcg3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ABC transporters | ABCC6;ABCA4;ABCA7;ABCB3L1;ABCB6A;ABCG5;ABCG8;ABCB7;ABCC8 |
Abcg3 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by Abcg3 itself. We selected most functions Abcg3 had, and list some proteins which have the same functions with Abcg3. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | P2RX3B;MAP2K3;RAF1;ITPK1A;MYLK2;PC;DYNC2H1;ADCK1;OXSR1 |
ATPase activity | MYH8;CLPB;MACF1;PEX6;DYNC1H1;KIF23;KIF2B;DNAH11;DDX3X |
ATPase activity, coupled to transmembrane movement of substances | ABCC10;ABCB5;ATP6V1D;ABCB10;TAP1;ABCC6;ABCD4;IPO8;ABCG2D |
drug transmembrane transporter activity | Abcb1b;SLC47A2;SLCO1B2;SLC22A18;SLC18A1;SLC18A3B;ABCG2D;SLC18A3A;SLC47A1 |
Abcg3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Abcg3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Abcg3.
Agr2; Ppia; Cfl1; Cdc42; Pfn1; Slc9a3r1; Anxa4; Ces1e; Lgals4; Anxa13; Lgals2; Dstn
- Q&As
- Reviews
Q&As (21)
Ask a questionABCG3 deficiency or overexpression can have physiological consequences, such as altered sterol levels, disturbed lipid metabolism, or increased susceptibility to certain diseases.
Yes, Abcg3 is unique among ABC genes in not having several highly conserved residues in the A and C domains of the NBF.
ABCG3 interacts with various cellular components and pathways involved in lipid metabolism, such as ATP-binding cassette transporters, nuclear receptors, and lipid synthesis enzymes.
Abcg3 may not bind ATP and would,ATP and would, therefore, have to dimerize with another subunit to form a functional trans- porter.
ABCG3 activity is regulated through various mechanisms, including transcriptional control, post-transcriptional modifications, and protein-protein interactions.
Currently, there are no specific pharmacological inhibitors or activators of ABCG3 reported in the literature.
The protein may function in lymphocytes. It is possible that the gene participates in the transport of specific peptides or hydrophobic compounds from these cells.
The ABCG3 gene was initially identified and characterized through genetic and molecular studies, including gene expression profiling, sequencing, and functional assays.
ABCG3 expression can vary during development or in different life stages. For example, its expression may be higher during embryonic development or in specific tissues during adulthood.
ABCG3 has the potential to be targeted for therapeutic interventions or drug development, particularly in conditions related to sterol metabolism disorders or cholesterol-related diseases.
ABCG3 expression can be influenced by genetic factors, including single nucleotide polymorphisms, as well as epigenetic modifications, such as DNA methylation or histone modifications.
For Abcg3, the highest levels of expression were found in thymus and spleen.
The Abcg3 gene has 16 exons, including one 5 non-coding exon.
ABCG3 is known to transport sterols, such as plant sterols or cholesterol, across cell membranes. It may also transport other lipids or lipid-related molecules.
Mutations in the ABCG3 gene can lead to sitosterolemia, a rare autosomal recessive disorder characterized by the accumulation of plant sterols in the body.
Sitosterolemia is the primary genetic disorder linked to ABCG3 mutations, characterized by the impaired excretion of plant sterols and increased absorption from the diet.
Certain genetic polymorphisms in ABCG3 have been associated with altered cholesterol levels, increased risk of atherosclerosis, or other lipid-related disorders.
ABCG3 shares functional similarities with other ABC transporters, particularly ABCG1 and ABCG2, in terms of their involvement in cellular lipid transport and homeostasis.
ABCG3 is primarily localized to the cell membrane, specifically the plasma membrane or the membranes of specific organelles, depending on the cell type.
Customer Reviews (5)
Write a reviewIt enabled versatile experimentation.
The protein product's high bioactivity ensured its effectiveness in functional assays, providing accurate and meaningful results.
I appreciated the product's consistent performance in my experiments, as it exhibited minimal batch-to-batch variability, ensuring reliable and reproducible results
The protein product's high level of bioavailability made it suitable for a wide range of applications.
The protein product's low background noise in my experiments reflected its purity and minimized interference from impurities.
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