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ACD

Official Full Name

adrenocortical dysplasia homolog (mouse)
Overview

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.
Synonyms

ACD; adrenocortical dysplasia homolog (mouse); adrenocortical dysplasia protein homolog; Pip1; POT1 and TIN2 organizing protein; Ptop; TIN2 interacting protein 1; Tint1; Tpp1; POT1 and TIN2-interacting protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ACD-154H	Recombinant Human ACD Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	ACD-9097HCL	Recombinant Human ACD 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ACD-9096HCL	Recombinant Human ACD 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ACD-3725H	Recombinant Human ACD protein, His-tagged	E.coli	His	1-351 aa	$319 / 25ug
Human	ACD-1657H	Recombinant Human ACD protein, His & T7-tagged	E.coli	His/T7	Glu244~Pro432 (Accession # Q96AP0)	Inquiry
Human	ACD-776HF	Recombinant Full Length Human ACD Protein, GST-tagged	In Vitro Cell Free System	GST	544 amino acids	Inquiry
Human	ACD-0512H	Recombinant Human ACD Protein (Glu217-Pro405), N-His-tagged	E.coli	N-His	Glu217-Pro405	Inquiry
Mouse	Acd-481M	Recombinant Mouse Acd Protein, His-tagged	E.coli	His	Glu21~Glu175	Inquiry
Rat	ACD-448R	Recombinant Rat ACD Protein	Mammalian Cell	His		Inquiry
Rat	Acd-482R	Recombinant Rat Acd Protein, His-tagged	E.coli	His	Asn147~Glu342	Inquiry
Rat	ACD-103R-B	Recombinant Rat ACD Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	ACD-103R	Recombinant Rat ACD Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	ACD-7144Z	Recombinant Zebrafish ACD	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ACD Related Articles

ACD involved in several pathways and played different roles in them. We selected most pathways ACD participated on our site, such as Cell Cycle, Cellular Senescence, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell Cycle	HDAC6;CEP72;DYRK1A;CTDNEP1;SMC2;CDC25C;FGFR1OP;WRAP53;LIN52
Cellular Senescence	AGO3;HIST1H1E;CDKN2C;KAT5;ASF1A;TERF2IP;LMNB1;MAPKAPK2B;RBB4L
Cellular responses to stress	DNAJB6;NUP50;UBN1;HSPA14;TXNRD2;HIST1H1B;AMBRA1;UVRAG;ATG7
Chromosome Maintenance	HJURP;MIS18BP1;POT1;TINF2;CENPC1;SMARCA5;APITD1;CENPP;RBBP7
DNA Damage/Telomere Stress Induced Senescence	TERF2;TINF2;H1F0;HMGA1-RS1;HIRA;TERF1;RAD50;UBN1;TERF2IP
Meiosis	TERF1;STAG1;MND1;POT1;TEX15;PSMC3IP;MSH4;FKBP6;SYNE1
Meiotic synapsis	SYCE2;TERF2IP;SUN1;FKBP6;SYCE1;SYCP2;TERF1;TINF2;POT1
Packaging Of Telomere Ends	TERF1;ACD;POT1A;TINF2;TERF2;POT1

ACD has several biochemical functions, for example, DNA binding, DNA polymerase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACD itself. We selected most functions ACD had, and list some proteins which have the same functions with ACD. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZFAND6;ZNF763;NUCB1;ZNF688;EF1;VPS72;FLI1A;HER13;ZNF654
DNA polymerase binding	FANCD2;SMARCA4;LONP1;PCNA;ACD;RAD51;HMGB1;CDK2AP1;FANCI
protein binding	NOL6;FSD2;LRRC75A-AS1;KRTAP5-6;ZNF649;AVPI1;SOX1;ZBTB7A;DNAI2

ACD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACD here. Most of them are supplied by our site. Hope this information will be useful for your research of ACD.

POT1; TINF2; TINF2

Yang, JS; Kang, SS; et al. Evaluation of Anticoagulants for Serologic Assays of Cholera Vaccination. CLINICAL AND VACCINE IMMUNOLOGY 21:854-858(2014).

Poli, M; Asperti, M; et al. Hepcidin antagonists for potential treatments of disorders with hepcidin excess. FRONTIERS IN PHARMACOLOGY 5:-(2014).