ACOT1
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Official Full Name
acyl-CoA thioesterase 1
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Synonyms
ACOT1; acyl-CoA thioesterase 1; acyl-coenzyme A thioesterase 1; ACH2; CTE 1; LACH2; Acyl CoA thioesterase 1, cytosolic; Acyl coenzyme A thioesterase 1; CTE I; CTE Ib; Cte1; Cytosolic acyl CoA thioesterase 1; D12Ucla1; Inducible cytosolic acyl-coenzyme A thioester hydrolase; Long chain acyl CoA hydrolase; Long chain acyl CoA thioester hydrolase; CTE-I; CTE-Ib; long chain acyl-CoA hydrolase; long chain acyl-CoA thioester hydrolase; CTE-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- C
- Myc
- DDK
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | ACOT1-115H | Recombinant Human ACOT1 Protein, His-tagged | E.coli | His |
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| Human | ACOT1-9091HCL | Recombinant Human ACOT1 293 Cell Lysate | HEK293 | N/A |
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| Human | ACOT1-323H | Recombinant Human ACOT1 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | C-Myc/DDK |
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| Mouse | ACOT1-1195M | Recombinant Mouse ACOT1 Protein | Mammalian Cell | His |
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| Mouse | Acot1-3137M | Recombinant Mouse Acot1, His-tagged | E.Coli or Yeast | His | 419 |
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| Mouse | ACOT1-256M | Recombinant Mouse ACOT1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | ACOT1-256M-B | Recombinant Mouse ACOT1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ACOT1-456R | Recombinant Rat ACOT1 Protein | Mammalian Cell | His |
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| Rat | ACOT1-112R-B | Recombinant Rat ACOT1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ACOT1-112R | Recombinant Rat ACOT1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
ACOT1 involved in several pathways and played different roles in them. We selected most pathways ACOT1 participated on our site, such as Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid elongation | ELOVL1;HADHA;HSD17B12A;PTPLAD1;ELOVL4A;PTPLAD2;HSD17B12B;ELOVL5;MECR |
| Biosynthesis of unsaturated fatty acids | TECR;SCD5;HADHAB;HSD17B12A;ACOT5;HSD17B12B;ELOVL2;ACAA1;ACAA1A |
| Metabolic pathways | PCYT1BA;NAPRT1;HSD3B2;CYP3A7;MSMO1;NDUFA2;ACO2;COX11;ATP6V1F |
ACOT1 has several biochemical functions, for example, acyl-CoA hydrolase activity, carboxylic ester hydrolase activity, palmitoyl-CoA hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOT1 itself. We selected most functions ACOT1 had, and list some proteins which have the same functions with ACOT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acyl-CoA hydrolase activity | ACOT2;ACSBG2;ACOT11;ACOT5;ACOT8;ACOT1;ACOT10 |
| carboxylic ester hydrolase activity | CES1;LIPH;ACOT10;ABHD2A;LIPCA;AADACL2;ACOT2;ACOT11;CES2 |
| palmitoyl-CoA hydrolase activity | ACOT7;THEM5;ACOT1;ACOT2;THEM4;ACOT8;GNPAT;BAAT;PPT1 |
ACOT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOT1.
PCNA; Chmp4b
- Q&As
- Reviews
Q&As (6)
Ask a questionSeveral genetic mutations in the ACOT1 gene have been associated with metabolic disorders, including obesity and insulin resistance.
ACOT1 protein is localized in the cytoplasm of cells.
ACOT1 plays a crucial role in lipid metabolism by hydrolyzing long-chain acyl-CoA thioesters, which are intermediates in the beta-oxidation of fatty acids, and releasing free fatty acids that can be utilized for energy production or other metabolic processes.
ACOT1 is expressed in a variety of tissues, including the liver, heart, skeletal muscle, and brain.
ACOT1 is important for energy metabolism and is involved in regulating lipid storage and utilization. It has also been implicated in the development of obesity, metabolic disorders and cancer.
ACOT1 is a soluble protein that is not membrane-bound.
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