Acp5
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Official Full Name
acid phosphatase 5, tartrate resistant
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Overview
The histochemical identification of hairy cell leukemia via tartrate-resistant acid phosphatase assay has been a standard for over two decades. Anti-TRAcP antibody labels the cells of hairy cell leukemia (HCL) with a high degree of sensitivity and specifi -
Synonyms
ACP5; acid phosphatase 5, tartrate resistant; tartrate-resistant acid phosphatase type 5; tartrate resistant acid phosphatase; TRAP; TrATPase; tartrate-resistant acid ATPase; SPENCDI;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rabbit
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Acp5 Related Research Area
Acp5 involved in several pathways and played different roles in them. We selected most pathways Acp5 participated on our site, such as Lysosome, Osteoclast differentiation, Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Acp5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | NAPSA;AP4M1;CLN3;ATP6AP1;CTSH;CTSLA;CTPS1B;GALC;HEXB |
| Osteoclast differentiation | NCF2;PIK3R3;IL1A;PIK3CB;CYBA;NOX1;PIK3CG;LILRA3;PPP3R1 |
| Rheumatoid arthritis | ATP6V1D;FLT1;ATP6AP1;IL18;HLA-DRB3;CCL2;TNFSF13B;ATP6V0C;TGFB2 |
Acp5 has several biochemical functions, for example, acid phosphatase activity, ferric iron binding, ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Acp5 itself. We selected most functions Acp5 had, and list some proteins which have the same functions with Acp5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acid phosphatase activity | ACP5A;ACPP;ACP5;PPIP5K1;ACP2;PXYLP1;MINPP1A;MINPP1;ACP1 |
| ferric iron binding | TH;FTH1B;FTMT;FTH1;FXN;ACP5;FTH1A;Trf;FTL |
| ferrous iron binding | HEPH;ALKBH3;TH;ISCU;TRR1;TF;TET2;SERPINB1A;EGLN2 |
Acp5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Acp5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Acp5.
PDCD5; EGR2; RPA2; MAPK9; TNFSF10; PPP2CB; ZBTB16; SLC35F6; SNRNP40
- Q&As
- Reviews
Q&As (10)
Ask a questionthe loss of Acp5 significantly protected mice from BLM-induced lung injury and fibrosis, accompanied by a marked reduction in myofibroblast accumulation.
Alteplase, Filgrastim, and Streptozocin.
They are Metabolism; Metabolism of vitamins and cofactors; Metabolism of water-soluble vitamins and cofactors; Vitamin B2 (riboflavin) metabolism
ACP5 promoted A549 and NCI-H1975 cells undergoing epithelial-mesenchymal transition (EMT) via P53/Smad3 signaling.
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Diseases associated with ACP5 include spondyloenchondrodysplasia with Immune dysregulation and Hairy Cell Leukemia. Among its related pathways are metabolism of water-soluble. vitamins and cofactors and Metabolism
Serum concentration of ACP5 was likely associated with decreased lung function in IPF patients.
Acp5 is upregulated by transforming growth factor-β1 (TGF-β1) in a TGF-β receptor 1 (TGFβR1)/Smad family member 3 (Smad3)-dependent manner, after which Acp5 dephosphorylates p-β-catenin at serine 33 and threonine 41, inhibiting the degradation of β-catenin and subsequently enhancing β-catenin signaling in the nucleus, which promotes the differentiation, proliferation and migration of fibroblast.
ACP5 is evaluated as osteoclast differentiation/activity markers in serum and in culture.
Acp5 deficiency protects mice from BLM-induced lung injury and fibrosis coupled with a significant reduction of fibroblast differentiation and proliferation.
Customer Reviews (5)
Write a reviewArrived prompt - good service
Much better than similar products that I've used.
Used in protein electron microscopy structure analysis.Great.
Great performance in WB :)
Patient customer service, love it.
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