ACSM5
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Official Full Name
acyl-CoA synthetase medium-chain family member 5
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Synonyms
ACSM5; acyl-CoA synthetase medium-chain family member 5; acyl-coenzyme A synthetase ACSM5, mitochondrial; FLJ20581; Acyl CoA synthetase medium chain family member 5; Acyl coenzyme A synthetase ACSM5, mitochondrial; MACS3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ACSM5 involved in several pathways and played different roles in them. We selected most pathways ACSM5 participated on our site, such as Butanoate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Butanoate metabolism | GAD2;L2HGDH;ACSM2;ALDH5A1;HMGCS1;ABAT;BDH2;ACSM2B;HMGCS2 |
Metabolic pathways | UGT1A7C;LIPCA;TYMP;AKR1C3;OAT;ATP5J2;GBGT1;B4GALT6;PLCE1 |
ACSM5 has several biochemical functions, for example, ATP binding, GTP binding, butyrate-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSM5 itself. We selected most functions ACSM5 had, and list some proteins which have the same functions with ACSM5. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | PRPF4B;CSNK2A2A;STK38L;BAZ1B;DDX42;ATP6V1A;NLRP4B;KALRN;PAPSS2A |
GTP binding | RSG1;RAB3DA;ARL3L1;RAB10;KRAS;SEPT5A;SEPT7A;DNM3A;RAP1AB |
butyrate-CoA ligase activity | Acsm2a;PPP1CA;ACSM5;ACSM2B;ACSM3;AACS;ACSM4;ACSM2;ACSM1 |
metal ion binding | MOXD1L;ZNF396;MGAT4C;CISD2;ZFP652;ME3;ZNFL1;RPE;GTPBP8 |
ACSM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSM5.
EP300
- Q&As
- Reviews
Q&As (10)
Ask a questionACSM5 has been implicated in the regulation of mitochondrial function and biogenesis, particularly in the liver. Studies have suggested that its activity may be involved in the generation of acyl-carnitine derivatives, which can be transported into the mitochondria for further metabolism.
ACSM5 has been shown to participate in intracellular signaling pathways, particularly those involving lipid signaling molecules such as phospholipids and fatty acids. Its activity can affect the production and release of these signaling molecules, which can then activate downstream signaling pathways.
ACSM5 activity has been shown to vary among different tissues and cell types. For example, it is highly expressed in adipose tissue and skeletal muscle, but is relatively low in the liver. Its expression and activity can also be regulated by various factors, including nutritional status and hormonal signaling.
ACSM5 has been shown to play a role in the metabolism of certain drugs and xenobiotics in the body, particularly those containing a carboxyl group. Its activity results in the conversion of these compounds into their corresponding acyl-CoA derivatives, which can be further metabolized or stored in the body. This process can affect the bioavailability and clearance of these compounds in the body.
ACSM5 has been shown to play a role in both fatty acid oxidation and lipogenesis, depending on the specific substrate and metabolic context. Its activity can affect the balance between these two processes, and may contribute to the dysregulation of lipid metabolism in metabolic disorders such as obesity and diabetes.
ACSM5 has been implicated in the development and progression of metabolic disorders such as obesity and diabetes. Studies have shown that its expression is increased in adipose tissue in obesity, and that its activity may contribute to the dysregulation of lipid metabolism and insulin sensitivity in these conditions.
ACSM5 has been shown to participate in a number of intracellular signaling pathways involved in cellular growth, survival, and differentiation. For example, ACSM5 has been implicated in the activation of the PI3K/Akt pathway, which regulates cell proliferation and survival in response to growth factors and nutrients. ACSM5 has also been shown to be upregulated by the transcription factor PPARγ, which plays a role in adipogenesis and glucose metabolism. The exact mechanisms by which ACSM5 participates in these pathways are still being elucidated.
Animal studies have shown that ACSM5 deficiency can affect cellular metabolism and function, particularly in the liver and skeletal muscle. It has been suggested that this is due to alterations in lipid metabolism and mitochondrial function.
ACSM5 may play a role in regulating inflammatory processes, particularly in the context of obesity and its associated metabolic disorders. This is thought to be due to its involvement in the metabolism of certain fatty acids and other lipids that are implicated in inflammation.
Recent studies have suggested that ACSM5 inhibition may have anti-tumor effects, particularly in certain types of cancer such as hepatocellular carcinoma. This is thought to be due to alterations in lipid metabolism and mitochondrial function that affect cancer cell growth and survival.
Customer Reviews (5)
Write a reviewAffordable, high-quality protein that consistently delivers accurate results. Customer service was exceptional.
It's like a ray of sunshine in our experiments, bringing joy and reliable data. A true delight to work with!
Its high purity and activity have facilitated accurate quantification and precise molecular interactions. It has surpassed my expectations.
The protein's solubility is outstanding. It readily dissolves in our buffers, facilitating hassle-free experimentation and saving us valuable time.
We commend the outstanding attributes of this protein. Its solubility, activity, and consistency have made it an essential tool in our scientific investigations, aiding in the advancement of knowledge.
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