ADCK3
-
Official Full Name
aarF domain containing kinase 3
-
Overview
This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. -
Synonyms
ADCK3; aarF domain containing kinase 3; CABC1, chaperone, ABC1 activity of bc1 complex homolog (S. pombe) , chaperone, ABC1 activity of bc1 complex like (S. pombe) , chaperone ABC1 (activity of bc1 complex, S.pombe) like; chaperone activity of bc1 complex-like, mitochondrial; coenzyme Q8 homolog (yeast); COQ8; SCAR9; aarF domain containing protein kinase 3; ADCK 3; CABC 1; Chaperone ABC1 (activity of bc1 complex S.pombe) like; Chaperone ABC1 activity of bc1 complex homolog; Chaperone ABC1 like; Chaperone activity of bc1 complex like; Chaperone activity of bc1 complex like mitochondrial; Coenzyme Q8 homolog; COQ 8; MGC4849; OTTHUMP00000035734; OTTHUMP00000035735; OTTHUMP00000035736; OTTHUMP00000035737; OTTHUMP00000038685; aarF domain-containing protein kinase 3; chaperone, ABC1 activity of bc1 complex homolo; ARCA2; CABC1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- HEK293
- Mammalian Cell
- Sf9 Insect Cell
- GST
- His
- His (Fc)
- Avi
- Involved Pathway
- Protein Function
- Interacting Protein
- ADCK3 Related Articles
ADCK3 involved in several pathways and played different roles in them. We selected most pathways ADCK3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ADCK3 has several biochemical functions, for example, ADP binding, ATP binding, kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCK3 itself. We selected most functions ADCK3 had, and list some proteins which have the same functions with ADCK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ADP binding | MYO3A;LONP1;HSP104;CYB5R3;ERN1;TAP1;MYO9B;PRKAG2;APAF1 |
| ATP binding | ATP6V1A;CKMA;OPLAH;ATAD5B;SKIV2L;SUCLG1;HSPH1;NEK5;ACACA |
| kinase activity | CAMK2A;TAB3;CKBA;CSNK2A2A;TPK1;SGK2B;Aatk;PHKG1A;KALRN |
| protein binding | PI4KB;SNX31;GP9;ANKRD54;SDC4;JOSD1;PABPC4;PSMD5;VEGFAA |
ADCK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCK3.
RABAC1; AGTRAP; TMEM239; TMEM159; REEP6
- Q&As
- Reviews
Q&As (12)
Ask a questionADCK3 protein may have potential therapeutic applications in various diseases, including Parkinson's disease, breast cancer, and other conditions that are linked to CoQ10 deficiency. It may also be useful as a target for developing drugs that modulate CoQ10 biosynthesis.
One limitation to the use of ADCK3 protein in therapy is its stability and delivery to the target tissues. It is also unclear whether it can be administered orally or if it needs to be delivered via injection or inhalation. Additionally, more studies are needed to determine its safety, efficacy, and potential interactions with other drugs or medications.
ADCK3 protein has been shown to play a role in cell proliferation and migration and may have a potential role in cancer therapy. However, more studies are needed to determine its safety and efficacy.
ADCK3 protein has been studied for its potential therapeutic applications in various disorders, including mitochondrial diseases, cancer, and neurodegenerative disorders.
Currently, there are no drugs that directly target ADCK3 protein. However, there are drugs that indirectly affect the biosynthesis of CoQ10, such as statins, which are commonly used to lower cholesterol levels.
There are currently no clinical trials underway that focus on ADCK3 protein. However, there are ongoing studies investigating CoQ10 supplementation in various conditions, including heart disease and neurodegenerative disorders.
No, ADCK3 protein is found in various species, including humans, mice, rats, and zebrafish.
The use of ADCK3 protein as a therapeutic agent has not been extensively studied, so there may be potential risks and side effects that are not yet known. Additionally, using ADCK3 protein to directly modify CoQ10 levels may not be as effective or safe as other methods of increasing CoQ10 levels, such as taking CoQ10 supplements.
ADCK3 protein has been shown to play a role in the regulation of cellular stress response pathways and may have a potential role in treating neurodegenerative disorders.
Yes, studies have shown that ADCK3 protein levels may be decreased in patients with certain diseases, including Parkinson's disease and breast cancer. Therefore, it may have potential as a biomarker for these diseases.
Mitochondrial diseases are caused by a defect in mitochondrial function. ADCK3 protein has been shown to play a role in mitochondrial protein synthesis, and therefore it may have a potential role in treating mitochondrial diseases.
ADCK3 protein levels may provide indirect information about CoQ10 levels in the body, but it is not a direct diagnostic tool for CoQ10 deficiency. Diagnosis of CoQ10 deficiency usually requires specific tests that measure CoQ10 levels in blood or tissues.
Ask a Question for All ADCK3 Products
Required fields are marked with *
My Review for All ADCK3 Products
Required fields are marked with *
