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AKAP11

  • Official Full Name

    A kinase (PRKA) anchor protein 11

  • Synonyms

    PRKA11; AKAP-11; AKAP220; PPP1R44;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKAP11-397H Recombinant Human AKAP11 Protein, GST-tagged Wheat Germ GST
Human AKAP11-395H Recombinant Human AKAP11 Protein, His-tagged E.coli His Leu1650~Ala1901

AKAP11 involved in several pathways and played different roles in them. We selected most pathways AKAP11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AKAP11 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP11 itself. We selected most functions AKAP11 had, and list some proteins which have the same functions with AKAP11. You can find most of the proteins on our site.

Function Related Protein

AKAP11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP11 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP11.

  • Q&As
  • Reviews

Q&As (21)

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Can AKAP11 be a potential therapeutic target for certain diseases? 01/27/2023

Due to its involvement in various cellular processes and its interactions with signaling molecules, AKAP11 has the potential to be a therapeutic target for certain diseases. However, more research is needed to fully understand its roles and mechanisms in specific diseases. Further elucidating the functional significance of AKAP11 and its interactions with disease-associated proteins could lead to the development of targeted therapies in the future.

How does AKAP11 influence cellular processes such as cell proliferation and apoptosis? 12/30/2022

AKAP11 can influence cell proliferation and apoptosis through its interaction with signaling molecules involved in these processes. By regulating cAMP levels and PKA signaling, AKAP11 can modulate cellular responses to growth factors and other signals that regulate cell proliferation. Additionally, by interacting with transcription factors and chromatin remodelers, AKAP11 can impact gene expression patterns involved in cell survival and apoptosis.

What role does AKAP11 play in cellular signaling pathways? 07/31/2022

AKAP11 acts as a scaffold protein, bringing together various signaling molecules and coordinating their activities. By anchoring PKA to specific locations, AKAP11 ensures that PKA phosphorylation events occur in close proximity to their relevant substrates, enhancing the specificity and efficiency of signaling cascades. AKAP11 can also interact with phosphodiesterases and protein phosphatases, affecting the regulation of cyclic AMP (cAMP) levels and dephosphorylation events associated with PKA signaling.

Where is AKAP11 located within the cell? 12/18/2021

AKAP11 is primarily found in the nucleus, but it can also be localized to the cytoplasm and the plasma membrane. Its subcellular localization can vary depending on cell type and signaling context.

What are the known roles of AKAP11? 10/16/2021

AKAP11 has been implicated in diverse cellular functions including cell cycle control, transcriptional regulation, ion channel modulation, cytoskeletal organization, and cell migration. Its roles extend to processes such as neuronal development, cardiac function, smooth muscle contraction, and immune response regulation.

Are there any post-translational modifications known to occur on AKAP11? 08/11/2021

Yes, AKAP11 can undergo post-translational modifications, which can regulate its activity and function. Some known post-translational modifications of AKAP11 include phosphorylation, acetylation, and SUMOylation. Phosphorylation of AKAP11 by protein kinases can modulate its interaction with binding partners and affect its function in cellular processes. Acetylation and SUMOylation can also impact the subcellular localization and activity of AKAP11.

Are there any disease associations or mutations associated with AKAP11? 02/16/2021

While there is limited research on disease associations or mutations specifically related to AKAP11, alterations in AKAP11 expression or function have been implicated in neurological disorders such as epilepsy and schizophrenia. Additionally, dysregulation of AKAP11-mediated PKA signaling has been implicated in cancer progression and cardiovascular diseases. Further studies are needed to fully understand the disease associations and potential mutations related to AKAP11.

Are there any known drugs or small molecules that target AKAP11? 02/13/2021

Currently, there are no specific drugs or small molecules that specifically target AKAP11. However, since AKAP11 interacts with downstream signaling molecules, targeting those molecules might indirectly affect AKAP11-mediated processes. For example, modulating the activity of PKA or phosphodiesterases, which interact with AKAP11, can indirectly impact AKAP11-dependent cellular processes.

Are there any disease associations with AKAP11? 05/14/2020

Although there is limited research on AKAP11's direct involvement in diseases, alterations in AKAP11 expression or function have been observed in certain conditions. For example, amplification of the AKAP11 gene has been found in some cancers, suggesting a potential role in tumorigenesis. Further studies are needed to fully understand the disease associations and clinical implications of AKAP11.

Can AKAP11 be a therapeutic target? 12/07/2019

The precise role of AKAP11 in various cellular processes and diseases is still being elucidated, but its involvement in critical signaling pathways makes it a potential target for therapeutic intervention. Modulating AKAP11's interactions with PKA or other signaling molecules could have therapeutic implications in conditions where these pathways are dysregulated, such as cancer or cardiovascular diseases. However, more research is needed to fully assess the therapeutic potential of targeting AKAP11.

Are there any known protein complexes or multi-protein assemblies that include AKAP11? 09/17/2019

Yes, AKAP11 is known to participate in protein complexes and multi-protein assemblies. One well-characterized example is the AKAP11-PKA complex, where AKAP11 anchors PKA to specific subcellular locations. AKAP11 can also interact with other proteins involved in cAMP signaling, such as phosphodiesterases and protein phosphatases, forming larger signaling complexes. Additionally, AKAP11 can be part of larger protein complexes involved in transcriptional regulation or chromatin remodeling processes.

What other proteins interact with AKAP11? 04/25/2019

AKAP11 interacts with a variety of proteins, allowing it to participate in diverse cellular processes. Some of the known binding partners of AKAP11 include protein kinase A (PKA), phosphodiesterases (PDEs), protein phosphatases, transcription factors, chromatin remodelers, and various signaling molecules involved in cyclic AMP (cAMP) signaling pathways.

Can AKAP11 influence gene expression? 02/12/2019

Yes, AKAP11 has been shown to influence gene expression through its interactions with transcriptional regulators. It can interact with transcription factors and chromatin remodelers, facilitating their recruitment to specific gene promoters or enhancers. This allows AKAP11 to regulate the expression of target genes involved in various cellular processes.

How is AKAP11 involved in cardiac function? 12/18/2018

AKAP11 is present in cardiac cells and plays a crucial role in regulating cyclic AMP (cAMP) signaling, which is essential for cardiac function. By anchoring PKA and other signaling molecules to specific sites within cardiomyocytes, AKAP11 helps coordinate signaling events involved in cardiac contraction, relaxation, and other aspects of cardiovascular physiology.

Does AKAP11 have any binding partners? 11/25/2018

Yes, AKAP11 interacts with various proteins involved in signaling pathways. Its main binding partner is PKA, to which it anchors and regulates its activity. AKAP11 can also interact with other AKAPs, phosphodiesterases, protein phosphatases, ion channels, and other signaling molecules, forming dynamic protein complexes for specific cellular functions.

Is there any ongoing research on AKAP11? 09/25/2018

Yes, research on AKAP11 is ongoing to further understand its roles in cellular signaling, disease mechanisms, and potential therapeutic targets. Studies aim to unravel the specific interactions and molecular mechanisms of AKAP11 in different cellular contexts to shed light on its functional significance.

Does AKAP11 play a role in neuronal development or function? 09/24/2018

AKAP11 has been implicated in neuronal development and function. It is expressed in the developing nervous system and plays a role in neuronal differentiation, axon guidance, and synapse formation. AKAP11 can also influence neuronal excitability and synaptic plasticity through its interactions with ion channels, neurotransmitter receptors, and signaling molecules involved in neuronal signaling pathways.

How is AKAP11 involved in cellular compartmentalization and subcellular localization? 11/29/2016

AKAP11 contains targeting domains that facilitate its binding to specific subcellular locations. It can anchor PKA and other signaling molecules to distinct cellular compartments, such as the plasma membrane, mitochondria, nucleus, and Golgi apparatus. By localizing PKA signaling to specific sites, AKAP11 ensures precise and efficient signaling, allowing for spatial regulation of cellular processes.

Is there any connection between AKAP11 and neurological disorders? 05/26/2016

Some studies suggest a potential link between AKAP11 and neurological disorders. AKAP11 has been found to be involved in the development and plasticity of neurons, and dysregulation of AKAP11 expression or function may contribute to neurological disorders such as epilepsy and schizophrenia. However, further research is needed to fully understand the role of AKAP11 in these conditions.

Are there different isoforms of AKAP11? 04/19/2016

Yes, alternative splicing of the AKAP11 gene gives rise to multiple isoforms. These isoforms may have distinct functions or expression patterns in different tissues or cell types, but their specific roles and significance are still being investigated.

Is AKAP11 expressed in all cell types or is its expression tissue-specific? 03/12/2016

AKAP11 exhibits tissue-specific expression patterns, with varying levels of expression across different cell types and tissues. While it is widely expressed in various cell types, its expression levels and functional roles may differ depending on the specific tissue or cell type. Further studies are needed to fully characterize the tissue-specific expression patterns of AKAP11.

Customer Reviews (4)

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Reviews
12/05/2021

    The purity and functionality of the AKAP11 protein ensure its suitability for my specific experimental needs, providing a solid foundation for my scientific investigations.

    05/01/2020

      The AKAP11 protein is an exceptional product that perfectly aligns with my experimental requirements.

      01/11/2020

        With its outstanding quality, I am confident in obtaining reliable and accurate results in my research endeavors.

        07/16/2017

          the manufacturer's technical support team has consistently demonstrated their expertise and dedication in solving any challenges that may arise.

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