akap13

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akap13

Official Full Name A kinase (PRKA) anchor protein 13
Background The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.
Synonyms AKAP13; A kinase (PRKA) anchor protein 13; LBC, lymphoid blast crisis oncogene; A-kinase anchor protein 13; AKAP Lbc; ARHGEF13; BRX; c lbc; HA 3; Ht31; PROTO LB; p47; AKAP-13; LBC oncogene; A-kinase anchoring protein; lymphoid blast crisis oncogene; huma
    • Type:
    • Species :
    • Human
    • Source :
    • E. coli
    • Wheat Germ
    • Tag :
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKAP13-398H Recombinant Human AKAP13 protein, GST-tagged E. coli GST
    Human AKAP13-399H Recombinant Human AKAP13 Protein, GST-tagged Wheat Germ GST
    Human AKAP13-45HCL Recombinant Human AKAP13 cell lysate N/A

    akap13 involved in several pathways and played different roles in them. We selected most pathways akap13 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G Protein Signaling Pathways, G alpha (12/13) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with akap13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell death signalling via NRAGE, NRIF and NADE ARHGAP4A; DCLRE1B; ARHGEF3; FGD4A; ABR; MCF2L; ARHGEF17; FGD4; ARHGEF9; ARHGEF18
    G Protein Signaling Pathways Akap2; GNA13; Akap3; GNB5B; AKAP1; GNG13B; AKAP10; KCNJ3; AKAP12B; AKAP4
    G alpha (12/13) signalling events KALRNB; OBSCN; ADRA1B; DCLRE1B; ARHGEF1B; RHOAE; ITSN1; ARHGEF18A; RHOC; GNA13
    GPCR downstream signaling S1PR1; GRP; DGKB; PRKCHB; GAL; LPAR5A; TIAM2; CNR2; CASR; OPN4.1
    NRAGE signals death through JNK ECT2; FGD2; ARHGEF1A; PLEKHG2; AKAP13; ARHGEF18A; MCF2L; OBSCN; ARHGAP4A; ABR
    Regulation of RhoA activity ARHGEF25; ARHGEF18; ABR; ARHGEF3; DEF6; MCF2L; OBSCN; FARP1; AKAP13; ARHGEF10
    Rho GTPase cycle ARHGAP17B; DEPDC7; RHOT2; GDI1; CHN1; RHOF; GMIP; ARHGAP18; RHOJ; ARHGAP1
    Signal Transduction RLN1; C; TNKS2; PDK3B; KLHL12; OR56A1; ARHGAP17B; ARHGAP18; KREMEN1; BCO2

    akap13 has several biochemical functions, for example, Rho GTPase binding, Rho guanyl-nucleotide exchange factor activity, cAMP-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by akap13 itself. We selected most functions akap13 had, and list some proteins which have the same functions with akap13. You can find most of the proteins on our site.

    Function Related Protein
    Rho GTPase binding DIAP3; RHOH; ROCK2A; DIAPH1; PFN1; AKAP13; ARHGEF16; KIF3B; DAAM1B; CSDA
    Rho guanyl-nucleotide exchange factor activity ARHGEF1; ARHGEF6; ABR; FARP2; ARHGEF7B; ARHGEF37; ARHGEF25; RASGRF2; PLEKHG5; TRIOA
    cAMP-dependent protein kinase activity AKAP13; PRKACG; PRKACB; PRKX; PRKAA1; PRKACA; PRKAG1
    metal ion binding MORC2B; ZBTB46; FBP1; TRIM30A; PVALB6; SDHDB; NRP2A; SIRT7; ZSCAN4; ARHGEF28
    protein binding CIRH1A; CROP; PTPN3; ARL3; FAM19A1; UBB; PFN1; HIST1H2AM; ABCG8; SRSF2
    protein complex scaffold AKAP13; CAV1; SLC9A3R2; SEPT2; CAV3; KLHL17; SLC9A3R1; WWC1; TELO2; CAPN3
    protein kinase A binding DACT2; AKAP4; RPS3; AKAP13; AKAP12; AKAP17A; DACT1; AKAP12B; Akap3; AKAP5
    signal transducer activity OLFR498; OLFCH1; TAAR14F; AGTR1B; GOLT1B; V2RH14; TNK1; GHRHRL; PTGER4A; GNAO1A

    akap13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with akap13 here. Most of them are supplied by our site. Hope this information will be useful for your research of akap13.

    YWHAB; ESR1; YWHAG; TGM2; THRA; Ppara; YWHAZ; BAK1; RANBP2; uvrB; lysU; q7arb9_yerpe

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