AKR1C3 Protein


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Official Full Name aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
Background Aldo-Keto Reductase AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9alpha,11beta- PGF2 to PGD2. AKR1C3 can interconvert acti
Synonyms AKR1C3; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); HSD17B5, hydroxysteroid (17 beta) dehydrogenase 5; aldo-keto reductase family 1 member C3; DDX; dihydrodiol dehydrogenase X; HAKRB; KIAA0119; PGFS; prostagla
    • Species :
    • Human
    • Rat
    • Source :
    • E. coli
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKR1C3-26146TH Recombinant Human AKR1C3, His-tagged E.coli His
    Human AKR1C3-413H Recombinant Human AKR1C3 Protein, GST-tagged Wheat Germ GST
    Human AKR1C3-9533H Recombinant Human AKR1C3, GST-tagged E.coli GST
    Rat AKR1C3-600R Recombinant Rat AKR1C3 Protein Mammalian Cell His
    Human AKR1C3-49HCL Recombinant Human AKR1C3 cell lysate N/A
    Human AKR1C3-01H Recombinant Human AKR1C3 Protein E.coli
    Human AKR1C3-090H Recombinant Human AKR1C3 Protein, His-tagged E. coli His
    Human AKR1C3-50H Recombinant Human AKR1C3 Protein, His-tagged E.coli His

    AKR1C3 involved in several pathways and played different roles in them. We selected most pathways AKR1C3 participated on our site, such as Steroid hormone biosynthesis, Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Steroid hormone biosynthesis SULT2ST3; CYP2C37; UGT2B15; UGT1A7; UGT1A6; UGT2A2; CYP2C70; HSD3B4; UGT1AB; PPP1R2
    Arachidonic acid metabolism GGT5; PTGES3A; PTGS1; CYP2P9; PLA2G2A; PLA2G4A; CYP2AD6; CYP4B1; ALOX12E; PTGES
    Metabolic pathways HMGCRA; AGL; GCSH; PLCD1B; ALOX12B; PLD3; FBP1B; RDH12; BST1; NDUFA1
    Ovarian steroidogenesis IGF1R; FSHR; PRKACA; ACOT2; HSD3B4; PRKACG; HSD17B7; AKR1C3; GNAS; BMP6

    AKR1C3 has several biochemical functions, for example, 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, alditol:NADP+ 1-oxidoreductase activity, aldo-keto reductase (NADP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C3 itself. We selected most functions AKR1C3 had, and list some proteins which have the same functions with AKR1C3. You can find most of the proteins on our site.

    Function Related Protein
    15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity AKR1C3
    alditol:NADP+ 1-oxidoreductase activity AKR1B1; AKR7A2; PRKRA; AKR1C3; AKR1C2; AKR1A1; Akr1b3; AKR1C21; ADH4; AKR7A5
    aldo-keto reductase (NADP) activity KCNAB2; MIOX; AKR7A3; HSD3B5; AKR1C6; SDR42E1; CYB5A; HSD3B6; AKR1C4; HSD11B1LA
    androsterone dehydrogenase activity AKR1C4; AKR1C6; AKR1C21; AKR1C3
    delta4-3-oxosteroid 5beta-reductase activity AKR1C3; AKR1D1
    dihydrotestosterone 17-beta-dehydrogenase activity AKR1C21; HSD11B1LA; SDR16C6; HSD3B5; SDR42E1; H2-KE6; AKR1C3; AKR1C6; HSD3B6
    geranylgeranyl reductase activity AKR1C3; AKR1B8; AKR1B10
    indanol dehydrogenase activity AKR1B8; AKR1C3; AKR1B10
    ketoreductase activity AKR1C3; DHRS7CB; DHRS7CA
    ketosteroid monooxygenase activity AKR1C3; AKR1C21; AKR1C2
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NDUFS7; AKR1C4; AKR1C2; AKR1C21; AKR1C3; DCXR; CBR1; DHRS4; AKR1C6
    phenanthrene 9,10-monooxygenase activity AKR1C3; AKR1C21; MICAL2B; MICAL2; AKR1C2
    prostaglandin D2 11-ketoreductase activity AKR1C3
    prostaglandin-F synthase activity FAM213B; AKR1C3
    retinal dehydrogenase activity ALDH8A1; ALDH1A1; ALDH1A3; AKR1C6; AKR1B8; AKR1B10; Aldh1a7; AKR1C4; AKR1C3
    retinol dehydrogenase activity RDH12; ADH4; SDR16C5; SDR9C7; RDH11; ADH1; RDH7; RDH10; RDH8; ADH7
    testosterone 17-beta-dehydrogenase (NADP+) activity HSD17B14; AKR1C6; HSD17B3; AKR1C3
    testosterone dehydrogenase (NAD+) activity DHRS9; H2-KE6; HSD17B6; HSD17B2; HSD17B1; HSD17B8; AKR1C3
    trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity AKR1C2; AKR1C3; AKR1C21; DHDH

    AKR1C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C3.


    Chen, CC; Chu, CB; et al. Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification. BIOCHEMICAL PHARMACOLOGY 86:872-887(2013).
    Gram, A; Buchler, U; et al. Biosynthesis and Degradation of Canine Placental Prostaglandins: Prepartum Changes in Expression and Function of Prostaglandin F2alpha-Synthase (PGFS, AKR1C3) and 15-Hydroxyprostaglandin Dehydrogenase (HPGD). BIOLOGY OF REPRODUCTION 89:-(2013).

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