AKR1C3
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Official Full Name
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) -
Overview
Aldo-Keto Reductase AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9alpha,11beta- PGF2 to PGD2. AKR1C3 can interconvert acti -
Synonyms
AKR1C3;aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II);HSD17B5, hydroxysteroid (17 beta) dehydrogenase 5;aldo-keto reductase family 1 member C3;DDX;dihydrodiol dehydrogenase X;HAKRB;KIAA0119;PGFS;prostagla
Recombinant Proteins
- Human
- Rat
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Flag
- Avi
- Fc
Involved Pathway
AKR1C3 involved in several pathways and played different roles in them. We selected most pathways AKR1C3 participated on our site, such as Steroid hormone biosynthesis,Arachidonic acid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CHPF,PTGES3A,ALG9,CYP4A14,CNDP1,AKR1B10,RPIA,EXTL2,NDUFC2,CYP2A12 |
| Ovarian steroidogenesis | Adcy4,GDF9,FSHB,LHCGR,GNAS,BMP6,PTGS2,INS2,INSR,HSD3B6 |
| Arachidonic acid metabolism | CYP2C55,PLA2G4D,CYP2C54,CYP2C19,PTGR1,CYP2Y3,CBR1L,CYP4F18,GGT1,CYP4F11 |
| Steroid hormone biosynthesis | H2-KE6,CYP3A41B,SRD5A2A,UGT2B15,COMTA,CYP3A25,PPP1R2,UGT1A7C,CYP2B19,UGT5G1 |
Protein Function
AKR1C3 has several biochemical functions, for example, 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity,alditol:NADP+ 1-oxidoreductase activity,aldo-keto reductase (NADP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C3 itself. We selected most functions AKR1C3 had, and list some proteins which have the same functions with AKR1C3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| testosterone dehydrogenase (NAD+) activity | HSD17B2,HSD17B6,HSD17B1,H2-KE6,HSD17B8,DHRS9 |
| aldo-keto reductase (NADP) activity | HSD11B1LA,KCNAB2,AKR1C6,AKR1C4,KCNAB1,AKR1B10,HSD3B5,AKR1C21,CYB5A,H2-KE6 |
| phenanthrene 9,10-monooxygenase activity | MICAL2,MICAL2B,AKR1C21,AKR1C2 |
| ketoreductase activity | DHRS7CB,DHRS7CA |
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | AKR1C21,AKR1C2,DHDH |
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | DHRS4,AKR1C6,CBR1,AKR1C4,AKR1C2,NDUFS7,DCXR,AKR1C21 |
| dihydrotestosterone 17-beta-dehydrogenase activity | SDR42E1,H2-KE6,AKR1C21,SDR16C6,AKR1C6,HSD3B6,HSD11B1LA,HSD3B5 |
| retinal dehydrogenase activity | AKR1B8,AKR1C4,Aldh1a7,AKR1C6,ALDH1A3,AKR1B10,ALDH8A1,ALDH1A1 |
| androsterone dehydrogenase activity | AKR1C21,AKR1C4,AKR1C6 |
Interacting Protein
AKR1C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C3.
MAGEA11;RIF1;UBE2W;ACIN1;ZHX1
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References
- Chen, CC; Chu, CB; et al. Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification. BIOCHEMICAL PHARMACOLOGY 86:872-887(2013).
- Gram, A; Buchler, U; et al. Biosynthesis and Degradation of Canine Placental Prostaglandins: Prepartum Changes in Expression and Function of Prostaglandin F2alpha-Synthase (PGFS, AKR1C3) and 15-Hydroxyprostaglandin Dehydrogenase (HPGD). BIOLOGY OF REPRODUCTION 89:-(2013).
