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  • Official Full Name

    aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

  • Overview

    Aldo-Keto Reductase AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9alpha,11beta- PGF2 to PGD2. AKR1C3 can interconvert acti
  • Synonyms

    AKR1C3; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); HSD17B5, hydroxysteroid (17 beta) dehydrogenase 5; aldo-keto reductase family 1 member C3; DDX; dihydrodiol dehydrogenase X; HAKRB; KIAA0119; PGFS; prostagla;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKR1C3-01H Active Recombinant Human AKR1C3 Protein E.coli 1-323
Human AKR1C3-9533H Recombinant Human AKR1C3, GST-tagged E.coli GST 1-323a.a.
Human AKR1C3-413H Recombinant Human AKR1C3 Protein, GST-tagged Wheat Germ GST
Human AKR1C3-26146TH Recombinant Human AKR1C3, His-tagged E.coli His
Human AKR1C3-49HCL Recombinant Human AKR1C3 cell lysate N/A
Human AKR1C3-50H Recombinant Human AKR1C3 Protein, His-tagged E.coli His 1-323
Human AKR1C3-305H Recombinant Human AKR1C3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AKR1C3-1368HF Recombinant Full Length Human AKR1C3 Protein, GST-tagged In Vitro Cell Free System GST 323 amino acids
Human AKR1C3-3489H Recombinant Human AKR1C3 protein, His-tagged E.coli His 329aa
Human AKR1C3-090H Recombinant Human AKR1C3 Protein, His-tagged E. coli His 1-323
Human AKR1C3-305H-B Recombinant Human AKR1C3 Protein Pre-coupled Magnetic Beads HEK293
Human AKR1C3-1971HFL Recombinant Full Length Human AKR1C3 Protein, C-Flag-tagged Mammalian cells Flag
Rat AKR1C3-600R Recombinant Rat AKR1C3 Protein Mammalian Cell His
Rat AKR1C3-256R-B Recombinant Rat AKR1C3 Protein Pre-coupled Magnetic Beads HEK293
Rat AKR1C3-256R Recombinant Rat AKR1C3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AKR1C3 Related Articles
  • AKR1C3 Related Research Area

AKR1C3 involved in several pathways and played different roles in them. We selected most pathways AKR1C3 participated on our site, such as Steroid hormone biosynthesis, Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Steroid hormone biosynthesisPPP1R2;STS;HSD11B1;CYP3A7-CYP3AP1;UGT1A3;SRD5A2;HSD17B7;UGT2B7;HSD17B12B
Arachidonic acid metabolismPLA2G6;PLA2G4F;DPEP2;CYP4A12A;CYP2AD3;PTGR1;CBR1L;PLA2G4B;PLA2G12A
Ovarian steroidogenesisHSD3B1;INSR;GDF9;PRKACA;AKR1C3;INS2;LHB;PLA2G4D;PLA2G4A

AKR1C3 has several biochemical functions, for example, 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, alditol:NADP+ 1-oxidoreductase activity, aldo-keto reductase (NADP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C3 itself. We selected most functions AKR1C3 had, and list some proteins which have the same functions with AKR1C3. You can find most of the proteins on our site.

Function Related Protein
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
alditol:NADP+ 1-oxidoreductase activityAKR7A5;AKR1B1;AKR7A2;Akr1b3;AKR1C2;AKR1B8;AKR1B7;AKR1C3;PRKRA
aldo-keto reductase (NADP) activityHSD11B1LA;AKR1B1;AKR1C4;CYB5A;MIOX;SPR;HSD3B5;AKR1C6;H2-KE6
androsterone dehydrogenase activityAKR1C6;AKR1C21;AKR1C3;AKR1C4
delta4-3-oxosteroid 5beta-reductase activityAKR1C3;AKR1D1
dihydrotestosterone 17-beta-dehydrogenase activitySDR16C6;HSD3B5;H2-KE6;HSD3B6;AKR1C3;HSD11B1LA;SDR42E1;AKR1C6;AKR1C21
geranylgeranyl reductase activityAKR1B8;AKR1C3;AKR1B10
indanol dehydrogenase activityAKR1B10;AKR1C3;AKR1B8
ketoreductase activityAKR1C3;DHRS7CB;DHRS7CA
ketosteroid monooxygenase activityAKR1C21;AKR1C3;AKR1C2
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorAKR1C6;NDUFS7;AKR1C2;AKR1C3;DHRS4;AKR1C4;CBR1;AKR1C21;DCXR
phenanthrene 9,10-monooxygenase activityAKR1C21;MICAL2B;AKR1C3;AKR1C2;MICAL2
prostaglandin D2 11-ketoreductase activity
prostaglandin-F synthase activityFAM213B;AKR1C3
retinal dehydrogenase activityAKR1C6;AKR1B8;AKR1B10;ALDH1A1;ALDH8A1;AKR1C3;ALDH1A3;AKR1C4;Aldh1a7
retinol dehydrogenase activitySDR16C5;ADH4;DHRS7C;ADH1;AKR1C3;SDR9C7;RDH5;ADH7;RDH7
testosterone 17-beta-dehydrogenase (NADP+) activityHSD17B3;AKR1C6;HSD17B14;AKR1C3
testosterone dehydrogenase (NAD+) activityDHRS9;H2-KE6;AKR1C3;HSD17B6;HSD17B8;HSD17B1;HSD17B2
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activityAKR1C3;AKR1C2;AKR1C21;DHDH

AKR1C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C3.


Chen, CC; Chu, CB; et al. Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification. BIOCHEMICAL PHARMACOLOGY 86:872-887(2013).
Gram, A; Buchler, U; et al. Biosynthesis and Degradation of Canine Placental Prostaglandins: Prepartum Changes in Expression and Function of Prostaglandin F2alpha-Synthase (PGFS, AKR1C3) and 15-Hydroxyprostaglandin Dehydrogenase (HPGD). BIOLOGY OF REPRODUCTION 89:-(2013).
  • Q&As
  • Reviews

Q&As (17)

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Are there any ongoing clinical trials targeting AKR1C3 protein? 04/23/2023

Yes, there are ongoing clinical trials investigating AKR1C3 inhibitors in cancer treatment. These trials aim to evaluate the efficacy and safety of AKR1C3 inhibitors either as monotherapy or in combination with other treatments. Interested individuals can find more information about these trials on the website or consult with their healthcare provider.

Are there any diseases associated with AKR1C3 protein? 03/09/2023

AKR1C3 has been implicated in various diseases, including hormone-related cancers such as prostate and breast cancer. It has also been linked to polycystic ovary syndrome (PCOS), endometriosis, and certain metabolic disorders. AKR1C3 dysregulation or overexpression may play a role in the pathogenesis of these diseases.

Are there any known genetic variations or mutations in the AKR1C3 gene? 04/21/2022

Yes, genetic variations in the AKR1C3 gene have been identified. Some of these variations can result in altered enzyme activity or protein structure. Certain single nucleotide polymorphisms (SNPs) in the AKR1C3 gene have been associated with increased cancer risk or changes in drug metabolism.

What are the potential implications of AKR1C3 inhibition in hormone-related disorders? 03/09/2021

AKR1C3 inhibition can have potential implications in the treatment of hormone-related disorders. Inhibition of AKR1C3 can disrupt the synthesis and metabolism of hormones, which could be beneficial in diseases such as prostate and breast cancer, where hormone signaling plays a significant role. However, the potential impact on overall hormone balance and potential side effects need to be carefully considered in clinical applications.

Can AKR1C3 be targeted for the treatment of other diseases besides cancer? 12/23/2020

Yes, AKR1C3 has been explored as a potential target for the treatment of conditions beyond cancer. For example, inhibition of AKR1C3 has been investigated as a therapeutic approach for the treatment of endometriosis and metabolic disorders. Further research is needed to better understand its role in these diseases and its potential as a therapeutic target.

Is the expression of AKR1C3 regulated by any specific factors? 09/13/2020

Yes, the expression of AKR1C3 can be regulated by various factors. It is known to be regulated by steroid hormones such as androgens and estrogens, which can upregulate its expression in certain tissues. Additionally, other signaling pathways, such as those involving nuclear receptors and growth factors, can also regulate AKR1C3 expression. Understanding the regulatory mechanisms of AKR1C3 expression is important for elucidating its role in different diseases and developing targeted therapies.

Where is AKR1C3 protein found? 01/09/2020

AKR1C3 is present in various tissues, including the liver, prostate, breast, and adrenal glands. It is also expressed in certain cancer cells, such as prostate cancer and breast cancer.

What are the potential side effects of AKR1C3 inhibitors? 10/31/2019

Since AKR1C3 is involved in various physiological processes, the inhibition of its activity may have potential side effects. This can include alterations in hormone levels, as well as impacts on other metabolic and physiological pathways. Careful evaluation and monitoring of potential side effects are necessary during the development and clinical use of AKR1C3 inhibitors.

Is AKR1C3 protein involved in drug resistance? 10/06/2019

Yes, AKR1C3 has been associated with drug resistance in certain cancers. Its ability to metabolize drugs, such as anticancer agents, and convert them into inactive forms can reduce the efficacy of chemotherapy. Inhibition of AKR1C3 has been explored as a potential strategy to overcome drug resistance in cancer treatment.

Is AKR1C3 protein a potential therapeutic target? 10/03/2019

AKR1C3 is considered a potential therapeutic target in hormone-related cancers and other diseases where its dysregulation plays a role. Inhibitors of AKR1C3 are being developed and tested as potential therapeutic agents to block its activity and disrupt hormone metabolism in cancer cells. However, more research is needed to determine the clinical effectiveness of targeting AKR1C3.

Can AKR1C3 be used as a diagnostic or prognostic marker for cancer? 07/03/2019

AKR1C3 has been investigated as a potential diagnostic and prognostic marker in various cancers. Its overexpression in tumor tissues, as well as its association with hormone-related pathways, suggests it may have clinical relevance. However, more research is required to determine its utility as a reliable biomarker.

Are there any other functions or roles of AKR1C3 protein? 06/11/2019

AKR1C3 has been implicated in regulating oxidative stress, inflammation, and cellular proliferation in addition to its role in hormone metabolism. It is also involved in the metabolism of xenobiotics and drugs, such as anti-cancer agents and nonsteroidal anti-inflammatory drugs.

Are there any genetic mutations in AKR1C3 associated with diseases? 11/26/2018

Yes, genetic mutations in AKR1C3 have been associated with certain diseases. One example is the HSD3B2 gene mutation, which results in an inherited form of 3β-hydroxysteroid dehydrogenase deficiency. This deficiency affects the activity of AKR1C3 and impairs steroid hormone synthesis, leading to disorders of sexual development and other hormonal imbalances. Further investigation is needed to identify other potential disease-associated genetic mutations in AKR1C3.

Are there any inhibitors or drugs targeting AKR1C3 protein? 01/03/2018

Yes, several inhibitors and drugs have been developed to target AKR1C3. For example, the nonsteroidal anti-inflammatory drug indomethacin and the selective AKR1C3 inhibitor, ASP9521, have shown promising results in preclinical studies. However, further research is needed to validate their efficacy in clinical settings.

Are there any natural compounds that can inhibit AKR1C3 activity? 06/14/2017

Yes, several natural compounds have shown inhibitory effects on AKR1C3. For example, resveratrol, a compound found in grapes and red wine, has been shown to inhibit AKR1C3 activity. Additionally, flavonoids such as quercetin and chrysin have also demonstrated inhibitory effects on AKR1C3. Further research is needed to fully understand the potential of these natural compounds as AKR1C3 inhibitors and their effectiveness in disease treatment.

What are the potential therapeutic applications of AKR1C3 inhibitors? 03/27/2017

AKR1C3 inhibitors have shown potential therapeutic applications in various diseases. One primary area of interest is cancer treatment, particularly hormone-related cancers such as prostate and breast cancer. Inhibiting AKR1C3 can disrupt androgen and estrogen metabolism, which can be beneficial in reducing tumor growth and hormone-dependent cancer progression.

Are there any drugs currently available that specifically target AKR1C3? 02/01/2016

As of now, there are no FDA-approved drugs specifically targeting AKR1C3. However, several small molecule inhibitors have been developed and tested in preclinical studies. Some of these inhibitors have shown promising results in inhibiting AKR1C3 activity and suppressing tumor growth in animal models. These inhibitors are still in the early stages of development and have not been approved for clinical use.

Customer Reviews (4)

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    Its remarkable sensitivity and specificity make it a valuable tool for accurate and robust data analysis, bolstering the credibility of research outcomes.


      the AKR1C3 protein finds great utility in protein electron microscopy structure analysis, consistently delivering exceptional results.


        Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.


          Notably, it exhibits exceptional performance in ELISA assays, providing reliable and precise results in the detection and quantification of target molecules.

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