akr1c3 Protein, aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

akr1c3

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akr1c3

Official Full Name aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
Background Aldo-Keto Reductase AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9alpha,11beta- PGF2 to PGD2. AKR1C3 can interconvert acti
Synonyms AKR1C3; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); HSD17B5, hydroxysteroid (17 beta) dehydrogenase 5; aldo-keto reductase family 1 member C3; DDX; dihydrodiol dehydrogenase X; HAKRB; KIAA0119; PGFS; prostagla
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKR1C3-26146TH Recombinant Human AKR1C3, His-tagged E.coli His
    Human AKR1C3-413H Recombinant Human AKR1C3 Protein, GST-tagged Wheat Germ GST
    Human AKR1C3-49HCL Recombinant Human AKR1C3 cell lysate N/A
    Human AKR1C3-9533H Recombinant Human AKR1C3, GST-tagged E.coli GST
    Rat AKR1C3-600R Recombinant Rat AKR1C3 Protein Mammalian Cell His

    akr1c3 involved in several pathways and played different roles in them. We selected most pathways akr1c3 participated on our site, such as Steroid hormone biosynthesis, Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with akr1c3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Steroid hormone biosynthesis UGT1A7C; UGT1A6A; CYP2D10; COMTA; CYP3A7-CYP3AP1; HSD3B2; UGT2A1; AKR1C2; UGT1A2; SRD5A2A
    Arachidonic acid metabolism CYP2E1; GGT5A; GGTLC1; CYP2U1; CYP2P10; GPX2; DPEP2; FAAH2; CYP2C8; PTGS2
    Metabolic pathways DAO.3; ABP1; PTGES3A; MAT1A; COX17; PKMA; DHRS9; PNP5A; PNAT10; PLA2G1B
    Ovarian steroidogenesis Adcy4; IGF1; LHB; GDF9; INS2; AKR1C3; HSD3B2; FSHB; PTGS2; LDLR

    akr1c3 has several biochemical functions, for example, 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, alditol:NADP+ 1-oxidoreductase activity, aldo-keto reductase (NADP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by akr1c3 itself. We selected most functions akr1c3 had, and list some proteins which have the same functions with akr1c3. You can find most of the proteins on our site.

    Function Related Protein
    15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity AKR1C3
    alditol:NADP+ 1-oxidoreductase activity AKR1B7; AKR7A5; AKR1B8; AKR1A1; ADH4; AKR7A2; AKR1B1; AKR1C2; AKR1C21; PRKRA
    aldo-keto reductase (NADP) activity HSD3B5; AKR1B10; KCNAB1; MIOX; AKR1C4; HSD11B1LA; SPR; AKR1B1; AKR1C6; KCNAB2
    androsterone dehydrogenase activity AKR1C4; AKR1C21; AKR1C3; AKR1C6
    delta4-3-oxosteroid 5beta-reductase activity AKR1C3; AKR1D1
    dihydrotestosterone 17-beta-dehydrogenase activity HSD3B6; H2-KE6; AKR1C21; HSD3B5; AKR1C6; SDR42E1; SDR16C6; HSD11B1LA; AKR1C3
    geranylgeranyl reductase activity AKR1B8; AKR1B10; AKR1C3
    indanol dehydrogenase activity AKR1B8; AKR1B10; AKR1C3
    ketoreductase activity AKR1C3; DHRS7CA; DHRS7CB
    ketosteroid monooxygenase activity AKR1C21; AKR1C2; AKR1C3
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor AKR1C21; NDUFS7; DCXR; AKR1C2; DHRS4; AKR1C6; AKR1C3; CBR1; AKR1C4
    phenanthrene 9,10-monooxygenase activity MICAL2; AKR1C2; AKR1C3; MICAL2B; AKR1C21
    prostaglandin D2 11-ketoreductase activity AKR1C3
    prostaglandin-F synthase activity FAM213B; AKR1C3
    retinal dehydrogenase activity AKR1C6; AKR1C4; Aldh1a7; ALDH1A3; AKR1B10; ALDH8A1; ALDH1A1; AKR1C3; AKR1B8
    retinol dehydrogenase activity RDH1; BMP2; RDH10; RDH8; ADH4; SDR9C7; RDH5; DHRS7C; RDH12; ADH1
    testosterone 17-beta-dehydrogenase (NADP+) activity HSD17B3; AKR1C6; HSD17B14; AKR1C3
    testosterone dehydrogenase (NAD+) activity AKR1C3; HSD17B6; HSD17B1; H2-KE6; HSD17B2; DHRS9; HSD17B8
    trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity AKR1C21; AKR1C2; AKR1C3; DHDH

    akr1c3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with akr1c3 here. Most of them are supplied by our site. Hope this information will be useful for your research of akr1c3.

    MAGEA11; RIF1; UBE2W; ACIN1; ZHX1

    Chen, CC; Chu, CB; et al. Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification. BIOCHEMICAL PHARMACOLOGY 86:872-887(2013).
    Gram, A; Buchler, U; et al. Biosynthesis and Degradation of Canine Placental Prostaglandins: Prepartum Changes in Expression and Function of Prostaglandin F2alpha-Synthase (PGFS, AKR1C3) and 15-Hydroxyprostaglandin Dehydrogenase (HPGD). BIOLOGY OF REPRODUCTION 89:-(2013).

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