Recombinant Rat AKR1C3 Protein, His (Fc)-Avi-tagged

Cat.No. : AKR1C3-256R
Product Overview : Recombinant Rat AKR1C3 with His (Fc)-Avi tag was expressed and purified
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Source : HEK293
Species : Rat
Tag : His (Fc)-Avi
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : ≥85% by SDS-PAGE
Stability : Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Storage Buffer : PBS buffer

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (17)

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Are there any ongoing clinical trials targeting AKR1C3 protein? 04/23/2023

Yes, there are ongoing clinical trials investigating AKR1C3 inhibitors in cancer treatment. These trials aim to evaluate the efficacy and safety of AKR1C3 inhibitors either as monotherapy or in combination with other treatments. Interested individuals can find more information about these trials on the clinicaltrials.gov website or consult with their healthcare provider.

Are there any diseases associated with AKR1C3 protein? 03/09/2023

AKR1C3 has been implicated in various diseases, including hormone-related cancers such as prostate and breast cancer. It has also been linked to polycystic ovary syndrome (PCOS), endometriosis, and certain metabolic disorders. AKR1C3 dysregulation or overexpression may play a role in the pathogenesis of these diseases.

Are there any known genetic variations or mutations in the AKR1C3 gene? 04/21/2022

Yes, genetic variations in the AKR1C3 gene have been identified. Some of these variations can result in altered enzyme activity or protein structure. Certain single nucleotide polymorphisms (SNPs) in the AKR1C3 gene have been associated with increased cancer risk or changes in drug metabolism.

What are the potential implications of AKR1C3 inhibition in hormone-related disorders? 03/09/2021

AKR1C3 inhibition can have potential implications in the treatment of hormone-related disorders. Inhibition of AKR1C3 can disrupt the synthesis and metabolism of hormones, which could be beneficial in diseases such as prostate and breast cancer, where hormone signaling plays a significant role. However, the potential impact on overall hormone balance and potential side effects need to be carefully considered in clinical applications.

Can AKR1C3 be targeted for the treatment of other diseases besides cancer? 12/23/2020

Yes, AKR1C3 has been explored as a potential target for the treatment of conditions beyond cancer. For example, inhibition of AKR1C3 has been investigated as a therapeutic approach for the treatment of endometriosis and metabolic disorders. Further research is needed to better understand its role in these diseases and its potential as a therapeutic target.

Is the expression of AKR1C3 regulated by any specific factors? 09/13/2020

Yes, the expression of AKR1C3 can be regulated by various factors. It is known to be regulated by steroid hormones such as androgens and estrogens, which can upregulate its expression in certain tissues. Additionally, other signaling pathways, such as those involving nuclear receptors and growth factors, can also regulate AKR1C3 expression. Understanding the regulatory mechanisms of AKR1C3 expression is important for elucidating its role in different diseases and developing targeted therapies.

Where is AKR1C3 protein found? 01/09/2020

AKR1C3 is present in various tissues, including the liver, prostate, breast, and adrenal glands. It is also expressed in certain cancer cells, such as prostate cancer and breast cancer.

What are the potential side effects of AKR1C3 inhibitors? 10/31/2019

Since AKR1C3 is involved in various physiological processes, the inhibition of its activity may have potential side effects. This can include alterations in hormone levels, as well as impacts on other metabolic and physiological pathways. Careful evaluation and monitoring of potential side effects are necessary during the development and clinical use of AKR1C3 inhibitors.

Is AKR1C3 protein involved in drug resistance? 10/06/2019

Yes, AKR1C3 has been associated with drug resistance in certain cancers. Its ability to metabolize drugs, such as anticancer agents, and convert them into inactive forms can reduce the efficacy of chemotherapy. Inhibition of AKR1C3 has been explored as a potential strategy to overcome drug resistance in cancer treatment.

Is AKR1C3 protein a potential therapeutic target? 10/03/2019

AKR1C3 is considered a potential therapeutic target in hormone-related cancers and other diseases where its dysregulation plays a role. Inhibitors of AKR1C3 are being developed and tested as potential therapeutic agents to block its activity and disrupt hormone metabolism in cancer cells. However, more research is needed to determine the clinical effectiveness of targeting AKR1C3.

Can AKR1C3 be used as a diagnostic or prognostic marker for cancer? 07/03/2019

AKR1C3 has been investigated as a potential diagnostic and prognostic marker in various cancers. Its overexpression in tumor tissues, as well as its association with hormone-related pathways, suggests it may have clinical relevance. However, more research is required to determine its utility as a reliable biomarker.

Are there any other functions or roles of AKR1C3 protein? 06/11/2019

AKR1C3 has been implicated in regulating oxidative stress, inflammation, and cellular proliferation in addition to its role in hormone metabolism. It is also involved in the metabolism of xenobiotics and drugs, such as anti-cancer agents and nonsteroidal anti-inflammatory drugs.

Are there any genetic mutations in AKR1C3 associated with diseases? 11/26/2018

Yes, genetic mutations in AKR1C3 have been associated with certain diseases. One example is the HSD3B2 gene mutation, which results in an inherited form of 3β-hydroxysteroid dehydrogenase deficiency. This deficiency affects the activity of AKR1C3 and impairs steroid hormone synthesis, leading to disorders of sexual development and other hormonal imbalances. Further investigation is needed to identify other potential disease-associated genetic mutations in AKR1C3.

Are there any inhibitors or drugs targeting AKR1C3 protein? 01/03/2018

Yes, several inhibitors and drugs have been developed to target AKR1C3. For example, the nonsteroidal anti-inflammatory drug indomethacin and the selective AKR1C3 inhibitor, ASP9521, have shown promising results in preclinical studies. However, further research is needed to validate their efficacy in clinical settings.

Are there any natural compounds that can inhibit AKR1C3 activity? 06/14/2017

Yes, several natural compounds have shown inhibitory effects on AKR1C3. For example, resveratrol, a compound found in grapes and red wine, has been shown to inhibit AKR1C3 activity. Additionally, flavonoids such as quercetin and chrysin have also demonstrated inhibitory effects on AKR1C3. Further research is needed to fully understand the potential of these natural compounds as AKR1C3 inhibitors and their effectiveness in disease treatment.

What are the potential therapeutic applications of AKR1C3 inhibitors? 03/27/2017

AKR1C3 inhibitors have shown potential therapeutic applications in various diseases. One primary area of interest is cancer treatment, particularly hormone-related cancers such as prostate and breast cancer. Inhibiting AKR1C3 can disrupt androgen and estrogen metabolism, which can be beneficial in reducing tumor growth and hormone-dependent cancer progression.

Are there any drugs currently available that specifically target AKR1C3? 02/01/2016

As of now, there are no FDA-approved drugs specifically targeting AKR1C3. However, several small molecule inhibitors have been developed and tested in preclinical studies. Some of these inhibitors have shown promising results in inhibiting AKR1C3 activity and suppressing tumor growth in animal models. These inhibitors are still in the early stages of development and have not been approved for clinical use.

Customer Reviews (4)

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Reviews
10/30/2022

    Its remarkable sensitivity and specificity make it a valuable tool for accurate and robust data analysis, bolstering the credibility of research outcomes.

    04/18/2019

      the AKR1C3 protein finds great utility in protein electron microscopy structure analysis, consistently delivering exceptional results.

      09/14/2016

        Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.

        06/06/2016

          Notably, it exhibits exceptional performance in ELISA assays, providing reliable and precise results in the detection and quantification of target molecules.

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