Recombinant Human AKR1C3 Protein, His-tagged AKR1C3-090H

Recombinant Human AKR1C3 Protein, His-tagged


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Recombinant Human AKR1C3 Protein, His-tagged

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Cat.No. : AKR1C3-090H
Product Overview : Active recombinant C-terminal His-tagged human AKR1C3 protein (1-323) was expressed in E. coli.
Description : This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 40.4 kDa
Protein length : 1-323
Purity : ≥85% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme required to produce 1 μmol of NADP+, per minute at 37 centigrade in 50 mM KPO4 pH7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone.
Stability : ≥ 1 year
Storage : At -80 centigrade.
Storage Buffer : A solution in 100 mM sodium phosphate, pH 7.2, containing 20% glycerol, 100 mM sodium chloride, and 1 mM EDTA
SDS-PAGE analysis of PGFS :

Lane 1: MW Markers
Lane 2: PGFS (2 μg)
Lane 3: PGFS (5 μg)

Gene Name : AKR1C3 aldo-keto reductase family 1 member C3 [ Homo sapiens (human) ]
Official Symbol : AKR1C3
Synonyms : AKR1C3; aldo-keto reductase family 1 member C3; DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS; aldo-keto reductase family 1 member C3; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type II, brain; chlordecone reductase homolog HAKRb; dihydrodiol dehydrogenase 3; dihydrodiol dehydrogenase X; indanol dehydrogenase; prostaglandin F synthase; testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase; EC; EC; EC; EC; EC; EC; EC
Gene ID : 8644
mRNA Refseq : NM_003739
Protein Refseq : NP_003730
MIM : 603966
UniProt ID : P42330
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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