Recombinant Human AKR1C3 Protein, His-tagged AKR1C3-50H

Recombinant Human AKR1C3 Protein, His-tagged


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Recombinant Human AKR1C3 Protein, His-tagged

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Cat.No. : AKR1C3-50H
Product Overview : Recombinant human AKR1C3(1-323) protein with a C-terminal His-tag was expressed in E. coli.
Description : This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 40.4 kDa
Protein length : 1-323
Purity : ≥85% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme required to produce 1 μmol of NADP+ per minute at 37 centigrade in 50mM K3PO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone.
Applications : Enzyme Activity
Stability : ≥ 1 year
Storage : Store it at -80 centigrade
Storage Buffer : A solution in 100 mM sodium phosphate, pH 7.2, containing 20% glycerol, 100 mM sodium chloride, and 1 mM EDTA
SDS-PAGE Analysis of AKR1C3 :

Lane 1: MW Markers; Lane 2: PGFS (2 μg); Lane 3: PGFS (5 μg).

Gene Name : AKR1C3 aldo-keto reductase family 1 member C3 [ Homo sapiens (human) ]
Official Symbol : AKR1C3
Synonyms : AKR1C3; aldo-keto reductase family 1 member C3; DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS; aldo-keto reductase family 1 member C3; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type II, brain; chlordecone reductase homolog HAKRb; dihydrodiol dehydrogenase 3; dihydrodiol dehydrogenase X; indanol dehydrogenase; prostaglandin F synthase; testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase
Gene ID : 8644
mRNA Refseq : NM_001253908
Protein Refseq : NP_001240837
MIM : 603966
UniProt ID : P42330

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