Recombinant Human AKR1C3 Protein, His-tagged
|Product Overview :||Recombinant human AKR1C3(1-323) protein with a C-terminal His-tag was expressed in E. coli.|
- Gene Information
- Related Products
|Description :||This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.|
|Source :||E. coli|
|Molecular Mass :||40.4 kDa|
|Protein length :||1-323|
|Purity :||≥85% estimated by SDS-PAGE|
|Unit Definition :||One unit is defined as the amount of enzyme required to produce 1 μmol of NADP+ per minute at 37 centigrade in 50mM K3PO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone.|
|Applications :||Enzyme Activity|
|Stability :||≥ 1 year|
|Storage :||Store it at -80 centigrade|
|Storage Buffer :||A solution in 100 mM sodium phosphate, pH 7.2, containing 20% glycerol, 100 mM sodium chloride, and 1 mM EDTA|
|Gene Name :||AKR1C3 aldo-keto reductase family 1 member C3 [ Homo sapiens (human) ]|
|Official Symbol :||AKR1C3|
|Synonyms :||AKR1C3; aldo-keto reductase family 1 member C3; DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS; aldo-keto reductase family 1 member C3; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type II, brain; chlordecone reductase homolog HAKRb; dihydrodiol dehydrogenase 3; dihydrodiol dehydrogenase X; indanol dehydrogenase; prostaglandin F synthase; testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase|
|Gene ID :||8644|
|mRNA Refseq :||NM_001253908|
|Protein Refseq :||NP_001240837|
|UniProt ID :||P42330|
|◆ Recombinant Protein|
|AKR1C3-01H||Recombinant Human AKR1C3 Protein||+Inquiry|
|AKR1C3-090H||Recombinant Human AKR1C3 Protein, His-tagged||+Inquiry|
|AKR1C3-305H||Recombinant Human AKR1C3 Protein, His (Fc)-Avi-tagged||+Inquiry|
|AKR1C3-256R||Recombinant Rat AKR1C3 Protein, His (Fc)-Avi-tagged||+Inquiry|
|AKR1C3-3489H||Recombinant Human AKR1C3 protein, His-tagged||+Inquiry|
|AKR1C3-49HCL||Recombinant Human AKR1C3 cell lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (17)Ask a question
Yes, there are ongoing clinical trials investigating AKR1C3 inhibitors in cancer treatment. These trials aim to evaluate the efficacy and safety of AKR1C3 inhibitors either as monotherapy or in combination with other treatments. Interested individuals can find more information about these trials on the clinicaltrials.gov website or consult with their healthcare provider.
AKR1C3 has been implicated in various diseases, including hormone-related cancers such as prostate and breast cancer. It has also been linked to polycystic ovary syndrome (PCOS), endometriosis, and certain metabolic disorders. AKR1C3 dysregulation or overexpression may play a role in the pathogenesis of these diseases.
Yes, genetic variations in the AKR1C3 gene have been identified. Some of these variations can result in altered enzyme activity or protein structure. Certain single nucleotide polymorphisms (SNPs) in the AKR1C3 gene have been associated with increased cancer risk or changes in drug metabolism.
AKR1C3 inhibition can have potential implications in the treatment of hormone-related disorders. Inhibition of AKR1C3 can disrupt the synthesis and metabolism of hormones, which could be beneficial in diseases such as prostate and breast cancer, where hormone signaling plays a significant role. However, the potential impact on overall hormone balance and potential side effects need to be carefully considered in clinical applications.
Yes, AKR1C3 has been explored as a potential target for the treatment of conditions beyond cancer. For example, inhibition of AKR1C3 has been investigated as a therapeutic approach for the treatment of endometriosis and metabolic disorders. Further research is needed to better understand its role in these diseases and its potential as a therapeutic target.
Yes, the expression of AKR1C3 can be regulated by various factors. It is known to be regulated by steroid hormones such as androgens and estrogens, which can upregulate its expression in certain tissues. Additionally, other signaling pathways, such as those involving nuclear receptors and growth factors, can also regulate AKR1C3 expression. Understanding the regulatory mechanisms of AKR1C3 expression is important for elucidating its role in different diseases and developing targeted therapies.
AKR1C3 is present in various tissues, including the liver, prostate, breast, and adrenal glands. It is also expressed in certain cancer cells, such as prostate cancer and breast cancer.
Since AKR1C3 is involved in various physiological processes, the inhibition of its activity may have potential side effects. This can include alterations in hormone levels, as well as impacts on other metabolic and physiological pathways. Careful evaluation and monitoring of potential side effects are necessary during the development and clinical use of AKR1C3 inhibitors.
Yes, AKR1C3 has been associated with drug resistance in certain cancers. Its ability to metabolize drugs, such as anticancer agents, and convert them into inactive forms can reduce the efficacy of chemotherapy. Inhibition of AKR1C3 has been explored as a potential strategy to overcome drug resistance in cancer treatment.
AKR1C3 is considered a potential therapeutic target in hormone-related cancers and other diseases where its dysregulation plays a role. Inhibitors of AKR1C3 are being developed and tested as potential therapeutic agents to block its activity and disrupt hormone metabolism in cancer cells. However, more research is needed to determine the clinical effectiveness of targeting AKR1C3.
AKR1C3 has been investigated as a potential diagnostic and prognostic marker in various cancers. Its overexpression in tumor tissues, as well as its association with hormone-related pathways, suggests it may have clinical relevance. However, more research is required to determine its utility as a reliable biomarker.
AKR1C3 has been implicated in regulating oxidative stress, inflammation, and cellular proliferation in addition to its role in hormone metabolism. It is also involved in the metabolism of xenobiotics and drugs, such as anti-cancer agents and nonsteroidal anti-inflammatory drugs.
Yes, genetic mutations in AKR1C3 have been associated with certain diseases. One example is the HSD3B2 gene mutation, which results in an inherited form of 3β-hydroxysteroid dehydrogenase deficiency. This deficiency affects the activity of AKR1C3 and impairs steroid hormone synthesis, leading to disorders of sexual development and other hormonal imbalances. Further investigation is needed to identify other potential disease-associated genetic mutations in AKR1C3.
Yes, several inhibitors and drugs have been developed to target AKR1C3. For example, the nonsteroidal anti-inflammatory drug indomethacin and the selective AKR1C3 inhibitor, ASP9521, have shown promising results in preclinical studies. However, further research is needed to validate their efficacy in clinical settings.
Yes, several natural compounds have shown inhibitory effects on AKR1C3. For example, resveratrol, a compound found in grapes and red wine, has been shown to inhibit AKR1C3 activity. Additionally, flavonoids such as quercetin and chrysin have also demonstrated inhibitory effects on AKR1C3. Further research is needed to fully understand the potential of these natural compounds as AKR1C3 inhibitors and their effectiveness in disease treatment.
AKR1C3 inhibitors have shown potential therapeutic applications in various diseases. One primary area of interest is cancer treatment, particularly hormone-related cancers such as prostate and breast cancer. Inhibiting AKR1C3 can disrupt androgen and estrogen metabolism, which can be beneficial in reducing tumor growth and hormone-dependent cancer progression.
As of now, there are no FDA-approved drugs specifically targeting AKR1C3. However, several small molecule inhibitors have been developed and tested in preclinical studies. Some of these inhibitors have shown promising results in inhibiting AKR1C3 activity and suppressing tumor growth in animal models. These inhibitors are still in the early stages of development and have not been approved for clinical use.
Customer Reviews (4)Write a review
Its remarkable sensitivity and specificity make it a valuable tool for accurate and robust data analysis, bolstering the credibility of research outcomes. -
the AKR1C3 protein finds great utility in protein electron microscopy structure analysis, consistently delivering exceptional results. -
Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures. -
Notably, it exhibits exceptional performance in ELISA assays, providing reliable and precise results in the detection and quantification of target molecules. -
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