ALDH1A3
-
Official Full Name
aldehyde dehydrogenase 1 family, member A3
-
Overview
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form. -
Synonyms
ALDH1A3; aldehyde dehydrogenase 1 family, member A3; ALDH6; aldehyde dehydrogenase family 1 member A3; RALDH3; retinaldehyde dehydrogenase 3; RALDH-3; aldehyde dehydrogenase 6; acetaldehyde dehydrogenase 6; ALDH1A6;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- GST|His
- His
- His (Fc)
- Avi
- SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ALDH1A3 involved in several pathways and played different roles in them. We selected most pathways ALDH1A3 participated on our site, such as Glycolysis / Gluconeogenesis, Histidine metabolism, Tyrosine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | ALDOAB;ALDH1A3;ADH2-1;HK2;G6PC2;PGK1;AKR1A1;PDHA1A;FBP1 |
| Histidine metabolism | AMDHD1;ALDH9A1;HNMT;HAL;ALDH1B1;ALDH2.1;ABP1;CARNS1;ALDH2.2 |
| Tyrosine metabolism | GSTZ1;HGD;IL4I1;TPO;AOX1;PNMT;TAT;GOT2B;TYR |
| Phenylalanine metabolism | ALDH3B2;HPD;HPDB;GOT2B;GM4952;MAOB;GOT2;AOC3;GOT1 |
| beta-Alanine metabolism | ALDH2.2;ALDH7A1;CNDP2;GAD1B;HADHAA;ALDH3B2;ALDH2;CNDP1;SRM |
| Metabolism of xenobiotics by cytochrome P | GSTA1;CBR1;AKR7A5;ALDH3A1;UGT1A6B;UGT1A7;CBR2;GSTM5;ALDH3B2 |
| Drug metabolism - cytochrome P | GSTA1;GSTM1;MGST1.1;MGST1.2;UGT1A6A;UGT1A6B;UGT1A1;GSTM;ALDH3A1 |
| Metabolic pathways | PON3;ATP6V1B2;MGAT1A;PISD;mt-Atp8;NDST3;ST20-MTHFS;ALDH9A1B;ATP5O |
| Chemical carcinogenesis | CYP2C50;CYP2E1;CYP2C37;GSTM2;UGT2B15;CYP2A13;MGST1;ADH6;CYP2C54 |
ALDH1A3 has several biochemical functions, for example, NAD+ binding, aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH1A3 itself. We selected most functions ALDH1A3 had, and list some proteins which have the same functions with ALDH1A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD+ binding | HPGD;SIRT7;ALDH1A3;SIRT5;HADH;SIRT1;GLUD1;UXS1;SIRT3 |
| aldehyde dehydrogenase (NAD) activity | ALDH1L2;ALDH3B2;ALDH1A1;ALDH7A1;Aldh1a7;ALDH3A1;ALDH16A1;ALDH1B1;ALDH1A3 |
| aldehyde dehydrogenase [NAD(P)+] activity | ALDH3A1;ALDH3A2B;ALDH2;ALDH3A2A;ALDH3A2;ALDH3B2;ALDH3B1;ALDH1A3 |
| protein homodimerization activity | COQ9;SLC24A6;LSM1;MCL1;PRLR;RPL7;GRIK1;KYNU;GDF7 |
| retinal dehydrogenase activity | AKR1B10;ALDH1A3;AKR1B8;AKR1C4;AKR1C3;AKR1C6;ALDH8A1;Aldh1a7;ALDH1A1 |
| thyroid hormone binding | THRA;ALDH1A3;CRYM;THRB;CTSH |
ALDH1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH1A3.
- Q&As
- Reviews
Q&As (5)
Ask a questionALDH1A3 has been implicated in cancer stem cell maintenance and differentiation, making it a potential target for cancer therapy.
ALDH1A3 has implications beyond cancer, and its role in retinoic acid metabolism suggests potential therapeutic applications in developmental disorders and other diseases.
ALDH1A3 is involved in the EMT process, a crucial step in cancer metastasis, highlighting its significance in tumor invasion and spread.
ALDH1A3 overexpression has been observed in various cancers, including breast, lung, ovarian, and pancreatic cancers.
Clinical trials are exploring the therapeutic potential of targeting ALDH1A3, evaluating the safety and efficacy of novel drugs in cancer patients.
Customer Reviews (3)
Write a reviewThe combination of high-quality ALDH1A3 protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.
The manufacturer's extensive experience and expertise in the field of ALDH1A3 protein research make them a trusted partner.
The manufacturer's commitment to providing excellent technical support is highly valuable.
Ask a Question for All ALDH1A3 Products
Required fields are marked with *
My Review for All ALDH1A3 Products
Required fields are marked with *
