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Official Full Name aldehyde dehydrogenase 7 family, member A1
Background The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified.
Synonyms ALDH7A1; aldehyde dehydrogenase 7 family, member A1; ATQ1; alpha-aminoadipic semialdehyde dehydrogenase; 26g turgor protein homolog; alpha AASA dehydrogenase; alpha aminoadipic semialdehyde dehydrogenase; antiquitin 1; delta1 piperideine 6 carboxylate dehydrogenease; EPD; P6c dehydrogenase; PDE; Aldehyde dehydrogenase 7 A1; Antiquitin; antiquitin-1; OTTHUMP00000159189; OTTHUMP00000242046; alpha-AASA dehydrogenase; betaine aldehyde dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenase
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALDH7A1-452H Recombinant Human ALDH7A1 Protein, GST-tagged Wheat Germ GST
    Human ALDH7A1-868H Recombinant Human ALDH7A1, His tagged E.coli His
    Human ALDH7A1-8915HCL Recombinant Human ALDH7A1 293 Cell Lysate HEK293 N/A
    Mouse Aldh7a1-1358M Recombinant Mouse Aldh7a1 protein, His-tagged E.coli His
    Mouse ALDH7A1-1533M Recombinant Mouse ALDH7A1 Protein Mammalian Cell His
    Mouse Aldh7a1-481M Recombinant Mouse Aldh7a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat Aldh7a1-1359R Recombinant Rat Aldh7a1 protein, His-tagged E.coli His
    Rat ALDH7A1-623R Recombinant Rat ALDH7A1 Protein Mammalian Cell His
    Zebrafish ALDH7A1-11996Z Recombinant Zebrafish ALDH7A1 Mammalian Cell His

    aldh7a1 involved in several pathways and played different roles in them. We selected most pathways aldh7a1 participated on our site, such as Glycolysis / Gluconeogenesis, Ascorbate and aldarate metabolism, Fatty acid degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with aldh7a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycolysis / Gluconeogenesis ALDH3A2A; PDHA2; ALDH9A1B; PFKMA; PKM; GM5506; ALDOC; PGAM2; TPI1A; ACSS2
    Ascorbate and aldarate metabolism ALDH2; ALDH2.1; UGT1A6; UGT2A3; UGT1A6B; UGT1A1; MIOX; ALDH7A1; UGT1A7C; UGT1A2
    Fatty acid degradation ADH4; ACOX3; ADH2-2; ADH1B; HADHB; ACOX1; ALDH3A2; GCDHB; ACADM; GCDH
    Glycine, serine and threonine metabolism ALDH7A1; MAOB; CTH; SHMT1; ALAS1; PHGDH; SHMT2; AOC2; AGXT; CBS
    Valine, leucine and isoleucine degradation ALDH6A1; HMGCS1; ACADS; ALDH1B1; DLDH; AOX3; HADHAA; OXCT1; AOX2P; ACADM
    Lysine biosynthesis AADAT; ALDH7A1
    Arginine and proline metabolism CKMT2B; ALDH4A1; L3HYPDH; CKMT2; CKBB; DAO.2; SAT1A.2; DAO.1; GOT1; MAOB
    Histidine metabolism ALDH3A2A; MAOB; HDC; UROC1; CNDP1; AMDHD1; CNDP2; ALDH2.2; ALDH1B1; ALDH3A1
    Tryptophan metabolism CAT; CYP4F12; ALDH2.2; CCBL1; AANAT; ALDH9A1B; TDO2B; ACAT1; GCDH; AOX3L1
    beta-Alanine metabolism UPB1; SMS; SRM; ALDH3B1; HIBCH; GAD1B; DPYDB; CARNS1; GAD2; ALDH7A1
    Glycerolipid metabolism AGPAT4; ALDH9A1A.1; MOGAT1; PNLIPRP1; GPAM; DGAT1; PNLIP; CEL.1; STIL; MBOAT1
    Pyruvate metabolism ACACB; ALDH3A2; HAGH; PDHB; LDHBA; PDK2; ACSS2L; PDHA1A; PDHA1; PDP2
    Metabolic pathways FUT4; COX6B2; AMDHD1; B4GALT2; GNSB; AKR1B1L; ATPV0E2; CRLS1; CYP19A1; TYR
    Biosynthesis of amino acids OTC; THA1; PRPS1A; MAT2AA; TKT; PYCR2; GLULA; PGK2; PAH; PKMB

    aldh7a1 has several biochemical functions, for example, L-aminoadipate-semialdehyde dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, betaine-aldehyde dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by aldh7a1 itself. We selected most functions aldh7a1 had, and list some proteins which have the same functions with aldh7a1. You can find most of the proteins on our site.

    Function Related Protein
    L-aminoadipate-semialdehyde dehydrogenase activity ALDH7A1
    aldehyde dehydrogenase (NAD) activity ALDH5A1; ALDH3A1; ALDH16A1; ALDH4A1; ALDH3A2; ALDH1A1; ALDH7A1; ALDH1L1; ALDH1A3; ALDH1B1
    betaine-aldehyde dehydrogenase activity ALDH7A1
    protein binding FPR1; HBQ1; PI4K2A; ADCY6; PPIF; LZTS1; HNRPLL; ZNF473; ACVR2A; MAPK6

    aldh7a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with aldh7a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of aldh7a1.

    EPS8; DDA1; UBA5; RECQL5; Rc3h2; Rc3h1

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