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ALG11

  • Official Full Name

    ALG11 asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast) [ Homo sapiens ]

  • Overview

    This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19.
  • Synonyms

    AI849156; alg11; ALG11_HUMAN; Asparagine-linked glycosylation 11; Asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast); Asparagine-linked glycosylation protein 11 homolog; AW492253; B230397C21; GT8; KIAA0266; OTTMUSP00000022781; RGD1564725;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Arabidopsis thaliana (Mouse-ear cress)
  • Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
  • Chicken
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
  • Dictyostelium discoideum (Slime mold)
  • Homo sapiens (Human)
  • Human
  • Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
  • Mouse
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Xenopus laevis (African clawed frog)
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALG11-9571H Recombinant Human ALG11, His-tagged E.coli His 1-328a.a.
Human ALG11-2921H Recombinant Human ALG11 protein, His-tagged E.coli His 342-492 aa
Mouse ALG11-1542M Recombinant Mouse ALG11 Protein Mammalian Cell His
Mouse ALG11-463M Recombinant Mouse ALG11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ALG11-463M-B Recombinant Mouse ALG11 Protein Pre-coupled Magnetic Beads HEK293
Arabidopsis thaliana (Mouse-ear cress) RFL31382AF Recombinant Full Length Arabidopsis Thaliana Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-463)
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) RFL35537CF Recombinant Full Length Candida Albicans Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-609)
Danio rerio (Zebrafish) (Brachydanio rerio) RFL21183DF Recombinant Full Length Danio Rerio Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-500)
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) RFL1381DF Recombinant Full Length Debaryomyces Hansenii Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-616)
Dictyostelium discoideum (Slime mold) RFL2238DF Recombinant Full Length Dictyostelium Discoideum Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-505)
Homo sapiens (Human) RFL14602HF Recombinant Full Length Human Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-492)
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) RFL8239KF Recombinant Full Length Kluyveromyces Lactis Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-570)
Mus musculus (Mouse) RFL32748MF Recombinant Full Length Mouse Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-492)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL5801PF Recombinant Full Length Pongo Abelii Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-492)
Xenopus laevis (African clawed frog) RFL36290XF Recombinant Full Length Xenopus Laevis Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-486)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL30358XF Recombinant Full Length Xenopus Tropicalis Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-487)
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) RFL16625YF Recombinant Full Length Yarrowia Lipolytica Gdp-Man:Man(3)Glcnac(2)-Pp-Dol Alpha-1,2-Mannosyltransferase(Alg11) Protein, His-Tagged E.coli expression system His Full Length (1-635)
Zebrafish ALG11-8344Z Recombinant Zebrafish ALG11 Mammalian Cell His
Zebrafish ALG11-7488Z Recombinant Zebrafish ALG11 Mammalian Cell His
Chicken ALG11-4477C Recombinant Chicken ALG11 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ALG11 involved in several pathways and played different roles in them. We selected most pathways ALG11 participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
N-Glycan biosynthesisST6GAL2;MAN2A1;STT3A;ALG3;MAN1A;ALG10B;MGAT2;ALG12;DPM3
Metabolic pathwaysLPIN1;AGPAT9L;CCBL1;CKB;MDH1AA;MGAT3A;ATP6V1E1;CYP2C39;PLCD3

ALG11 has several biochemical functions, for example, GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG11 itself. We selected most functions ALG11 had, and list some proteins which have the same functions with ALG11. You can find most of the proteins on our site.

Function Related Protein
GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity

ALG11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG11.

UBE2G2

  • Q&As
  • Reviews

Q&As (20)

Ask a question
Is there a correlation between ALG11 defects and neurological diseases? 04/06/2023

Some ALG11 mutations may lead to central nervous system diseases, such as cerebral cortex atrophy, etc. However, a large number of studies are needed to support the adequacy and validity of the above relationship.

How is the effect of ALG11 defect on the cellular life activity process produced? 02/05/2023

The effects of ALG11 defects on cell life activities may include metabolic abnormalities, protein synthesis and secretion abnormalities, etc. The mechanism of these effects needs to be further explained.

What is the relationship between ALG11 gene family structure and evolution? 10/12/2022

ALG11 is part of the GMD family and is found in winged animals and other eukaryotes. More studies are needed to confirm the family structure and evolutionary relationship.

How to evaluate the clinical manifestations of ALG11-related synthase deficiency syndrome? 07/29/2022

The clinical manifestations of patients with ALG11 deficiency syndrome are complicated, and it is necessary to synthesize various evidences, such as clinical symptoms, magnetic resonance, nuclear magnetic resonance, X-ray and other comprehensive evaluation, to determine the specific disease type.

How to screen ALG11 gene function? 07/05/2022

The functional screening of ALG11 gene needs to be based on the special characteristics of its genome sequence and encoded protein, combined with the existing research results, and adopt appropriate screening technology to determine.

How specific is the glycosylase matrix of ALG11 gene? 05/27/2022

The relationship between ALG11 gene and specific matrix substances in the glycosylation process is not completely clear, and further research is needed.

How to evaluate the effect of abnormal function of ALG11 gene on the development and reproduction of organisms? 04/25/2022

At present, the effects of ALG11 gene defects on the development and reproduction of organisms still need to be explored.

What is the effect of ALG11 mutation on protein glycosylation? 11/01/2021

At present, the mechanism of the effect of ALG11 gene mutation on protein glycosylation needs to be studied at the cellular level to elucidate a comprehensive influence model.

How does ALG11 mediate cell membrane regeneration? 08/18/2021

ALG11 may be involved in cell membrane regeneration through the modification of membrane glycoproteins, glycolipids, peptides and other molecules.

Are there known quantitative ALG11 gene polymorphisms associated with other genetic or environmental factors? 05/20/2021

There is no evidence that ALG11 polymorphisms are associated with other genetic or environmental factors. But research is continuing.

What is the genomic structure and regulatory mechanism of ALG11? 05/05/2021

The ALG11 gene is composed of multiple exons that were included in previous genomic sequencing studies. The regulation mechanism still needs to be studied further.

Are ALG11 gene mutations associated with specific diseases? 03/29/2021

ALG11 gene mutations may be associated with heart disease and other syndromes associated with protein glycosylation. But more research is needed to confirm the evidence.

What is the influence mechanism of ALG11 defect on lipid metabolism? 01/27/2021

ALG11 defects may lead to lipid metabolism abnormalities by modifying protein modifications related to lipid metabolism. However, further studies are needed to determine the mechanism.

How to evaluate ALG11 expression and glycosylation to analyze the therapeutic mechanism of Cadoria? 08/19/2020

At present, there are not enough research results on how ALG11 affects the therapeutic mechanism of Cardoria, and more data are needed to support it in the future.

What are the unique characteristics of ALG11 expression patterns and post-transcriptional modifications? 06/01/2020

The post-transcriptional modification and expression patterns of ALG11 gene require more biochemical studies to further explain.

In which cell types or tissues is ALG11 gene highly expressed? 05/02/2020

The expression of ALG11 gene in different tissues and cell types may vary, please refer to relevant literature.

Does the influence mechanism of ALG11 defect on the regulation level of gene expression? 02/18/2020

The mechanism of ALG11 defect and its effect on glycosylation exist a series of complex regulatory mechanisms, which need to be further studied at the molecular and cellular levels.

What are the structural and functional characteristics of ALG11 encoded protein? 10/25/2019

The ALG11 encoding protein is involved in the process of protein glycosylation, and the details such as what mechanism achieves this process are still in the field of unstudied.

How to prevent regional mutation and sequence variation of ALG11 gene? 09/27/2019

To prevent the regional mutation or sequence variation of ALG11 gene, it is necessary to strengthen the collection and preservation of relevant biological samples, as well as perfect data management and maintenance systems.

How does ALG11 affect the occurrence and progression of lung lesions? 07/31/2019

More research is needed on the association between the ALG11 gene and lung disease, which has only been a concern in recent years.

Customer Reviews (4)

Write a review
Reviews
10/06/2022

    Widely available and easy to prepare.

    07/21/2022

      Easy to store, more stable.

      04/30/2021

        Compared with other methods, qPCR detection is better.

        05/26/2019

          Easy to purify in production, high purity.

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