ALKBH4
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Official Full Name
alkB, alkylation repair homolog 4 (E. coli)
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Synonyms
ALKBH4;alkB, alkylation repair homolog 4 (E. coli);21900;ENSG00000160993;ABH4;7q22.1;FLJ20013;probable alpha-ketoglutarate-dependent dioxygenase ABH4;probable alpha-ketoglutarate-dependent dioxygenase ABH4;alkylated DNA repair protein alkB homolog 4;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ALKBH4-476H | Recombinant Human ALKBH4 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ALKBH4-9585H | Recombinant Human ALKBH4, GST-tagged | E.coli | GST | 1-302a.a. | |
| Human | ALKBH4-1448HF | Recombinant Full Length Human ALKBH4 Protein, GST-tagged | In Vitro Cell Free System | GST | 302 amino acids |
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| Mouse | ALKBH4-1556M | Recombinant Mouse ALKBH4 Protein | Mammalian Cell | His |
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| Mouse | ALKBH4-476M-B | Recombinant Mouse ALKBH4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | ALKBH4-476M | Recombinant Mouse ALKBH4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rhesus Macaque | ALKBH4-307R | Recombinant Rhesus monkey ALKBH4 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | ALKBH4-135R | Recombinant Rhesus Macaque ALKBH4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rhesus Macaque | ALKBH4-135R-B | Recombinant Rhesus Macaque ALKBH4 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ALKBH4 Related Articles
ALKBH4 involved in several pathways and played different roles in them. We selected most pathways ALKBH4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ALKBH4 has several biochemical functions, for example, actin binding, demethylase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH4 itself. We selected most functions ALKBH4 had, and list some proteins which have the same functions with ALKBH4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | SPTAN1;DIAPH3;VILL;INO80;WDR1;ESPN;FHOD3;FKBP15;GBP1 |
| demethylase activity | CYP3A41B;CYP1A2;ALKBH4;KDM1A;CYP3A41A;CYP1A1 |
| metal ion binding | CLCNKB;KLF7A;SP3A;ZNF692;ARSF;ITGA10;TSNAX;ENDOU2;MGRN1A |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | TYW5;ALKBH4;HIF1AN;EGLN2;KDM5BB;KDM5C;P4HTM;EGLN3;C14orf169 |
| protein binding | GRASP;MED21;ERAL1;MAPK9;TAF1C;C1QBP;SCOC;TRIM37;NCS1 |
ALKBH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH4.
DTX2; DTX2; TRAF4
- Q&As
- Reviews
Q&As (14)
Ask a questionCurrent studies have shown that ALKBH4 protein may also play a role in cardiovascular disease.
At present, it is believed that ALKBH4 protein is related to RNA repair, and its correlation with DNA repair needs to be further confirmed.
Current studies have found that ALKBH4 protein is related to a variety of cancers, intracranial hemorrhage and other diseases.
The ALKBH4 protein is transcribed by the ALKBH4 gene and then translated into a protein.
Many studies have shown that the abnormal expression of ALKBH4 protein is related to the occurrence and development of some tumors.
There is no clear evidence that ALKBH4 protein is involved in the process of post-translational modification.
ALKBH4 protein is known to interact with a variety of genes, including other RNA modifying enzymes and DNA damage response genes.
ALKBH4 protein is mainly involved in RNA modification and regulation of gene expression.
The expression level of ALKBH4 gene is different in different tissues, and it may be regulated by exogenous factors.
The relationship between ALKBH4 protein and apoptosis has not been confirmed.
The structure of ALKBH4 protein is mainly characterized by the presence of methionine modification enzyme active center, which can assist RNA modification.
Current studies suggest that the expression of ALKBH4 protein is affected by environmental factors, including alkylating agents and oxidants.
ALKBH4 protein mainly modifies RNA molecules such as tRNA and rRNA.
The ALKBH4 protein has become an important target for some cancer treatments, including drug therapies targeting the protein.
Customer Reviews (4)
Write a reviewThe protein has low cytotoxicity.
Short half-life and high clearance rate.
The stability of this protein is relatively good, heat resistance, acid and alkaline resistance and protease degradation test results are very good.
This protein performed well by testing kinetic parameters such as enzymatic reaction rate, binding affinity and so on.
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