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Official Full Name arachidonate 8-lipoxygenase
Synonyms ALOX8;arachidonate 8-lipoxygenase;ENSMUSG00000020891;8-LOX;8S-LOX;Alox15b;11;11 B4;arachidonate 15-lipoxygenase B;arachidonate 15-lipoxygenase B;15-LOX-2;15-LOX-B;8S-lipoxygenase;15-lipoxygenase 2;arachidonate 15-lipoxygenase type II;arachidonate 15-lipoxygenase, second type;EC;
    • Species :
    • Mouse
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse ALOX8-1569M Recombinant Mouse ALOX8 Protein Mammalian Cell His

    alox8 involved in several pathways and played different roles in them. We selected most pathways alox8 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with alox8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism PLA2G4D; CYP2Y3; GGT5A; GPX1; CYP4F18; PLA2G3; PTGES3; CYP2C38; PTGS1; DPEP2
    Metabolic pathways ALDOB; ASAH2; PYGL; NDUFC2-KCTD14; LALBA; FPGS; ENPP7; GPT; PLA2G10; PIK3C2B
    Serotonergic synapse CYP2C50; APP; MAPK3; NRAS; MAOA; ALOX12; PRKCB; GNG3; ALOX12B; GNAI1

    alox8 has several biochemical functions, for example, 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity, 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity, 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by alox8 itself. We selected most functions alox8 had, and list some proteins which have the same functions with alox8. You can find most of the proteins on our site.

    Function Related Protein
    1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity ALOX8
    1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity ALOX8
    1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity ALOX8
    1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity ALOX8
    2-aminobiphenyl-2,3-diol 1,2-dioxygenase activity ALOX8
    2,2,3-trihydroxybiphenyl dioxygenase activity ALOX8
    2,3-dihydroxy DDT 1,2-dioxygenase activity ALOX8
    2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity ALOX8
    2,3-dihydroxy-p-cumate dioxygenase activity ALOX8
    2,3-dihydroxydiphenyl ether dioxygenase activity ALOX8
    2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity ALOX8
    2-aminophenol 1,6-dioxygenase activity ALOX8
    2-mercaptobenzothiazole dioxygenase activity ALOX8
    3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity ALOX8
    3,4-dihydroxyphenanthrene dioxygenase activity ALOX8
    3,5-dichlorocatechol 1,2-dioxygenase activity ALOX8
    3-hydroxy-2-naphthoate 2,3-dioxygenase activity ALOX8
    4,5-dihydroxybenzo(a)pyrene dioxygenase activity ALOX8
    4,5-dihydroxypyrene dioxygenase activity ALOX8
    4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity ALOX8
    4-hydroxycatechol 1,2-dioxygenase activity ALOX8
    5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity ALOX8
    5-aminosalicylate dioxygenase activity ALOX8
    7,8-dihydroxy benzo(a)pyrene dioxygenase activity ALOX8
    9,10-dihydroxybenzo(a)pyrene dioxygenase activity ALOX8
    arachidonate 15-lipoxygenase activity ALOX15; ALOX15B; ALOX8
    arachidonate 8(R)-lipoxygenase activity ALOX8
    arachidonate 8(S)-lipoxygenase activity ALOX8; ALOX15B
    benzo(a)pyrene 11,12-dioxygenase activity ALOX8
    benzo(a)pyrene 4,5-dioxygenase activity ALOX8
    benzo(a)pyrene 7,8-dioxygenase activity ALOX8
    benzo(a)pyrene 9,10-dioxygenase activity ALOX8
    calcium ion binding PLCD1; SULF2A; PCDH8; MMP13A; SYT6; PNLIPRP1; CMLC1; PLCD4; SYT5A; GPD2
    carbazole 1,9a-dioxygenase activity ALOX8
    catechol dioxygenase activity ALOX8
    chlorocatechol 1,2-dioxygenase activity ALOX8
    dihydroxydibenzothiophene dioxygenase activity ALOX8
    dihydroxyfluorene dioxygenase activity ALOX8
    dioxygenase activity ALOX5B.2; HPDB; ALKBH7; ALOX5B.3; ADOA; PHYHD1; KDM4C; KDM3B; LEPREL1; ADOB
    diphenyl ether 1,2-dioxygenase activity ALOX8
    hydroquinone 1,2-dioxygenase activity ALOX8
    iron ion binding CYP27A1; CYP1A; CYP2K17; CYP1D1; HBA1; ALKBH8; P3H2; TYW1; P4HA1A; CYP7B1
    linoleate 13S-lipoxygenase activity ALOX15B; ALOX12; ALOX8
    lipid binding PTGS1; PITPNC1; LPAR2; GLTP; ACOT11B; MELK; STARD10; SH3GL3; PLTP; SH3GL2
    metal ion binding NEK1; CACNA2D2; LMO7B; HE2; SPON2; ATP9A; ZNF812; ZNF292B; HE1B; AGAP5
    oxidoreductase activity ERO1L; RDH14B; TRR1; ZADH2; PHF2; CMAH; HIBADHA; RETSAT; FADS2; CYP4T8
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ADOB; TMLHE; ALOX12B; ALOX5A; ALOX8; ALOX5B.3; P4HA2; ALOX12E; ALOX12; P4HA3
    p-cumate 2,3-dioxygenase activity ALOX8
    phenanthrene dioxygenase activity ALOX8
    phenanthrene-4-carboxylate dioxygenase activity ALOX8
    protocatechuate 3,4-dioxygenase type II activity ALOX8
    pyrene dioxygenase activity ALOX8
    pyridine-3,4-diol dioxygenase activity ALOX8
    styrene dioxygenase activity ALOX8
    tetrachlorobenzene dioxygenase activity ALOX8

    alox8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with alox8 here. Most of them are supplied by our site. Hope this information will be useful for your research of alox8.

    Kawajiri, H; Piao, YS; et al. Synthesis of 8,9-leukotriene A(4) by murine 8-lipoxygenase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 338:144-148(2005).
    Furstenberger, G; Marks, F; et al. Arachidonate 8(S)-lipoxygenase. PROSTAGLANDINS & OTHER LIPID MEDIATORS 68-9:235-243(2002).

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