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Official Full Name anoctamin 6
Background This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms ANO6; anoctamin 6; TMEM16F, transmembrane protein 16F; anoctamin-6; DKFZp313M0720; transmembrane protein 16F; SCTS; BDPLT7; TMEM16F; MGC104751
    • Species :
    • Human
    • Source :
    • E.coli
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ANO6-340H Recombinant Human ANO6 Protein, His-tagged E.coli His
    Human ANO6-9683H Recombinant Human ANO6, GST-tagged E.coli GST

    ANO6 involved in several pathways and played different roles in them. We selected most pathways ANO6 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANO6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ion channel transport ATP11C; CLCN6; GSDMA2; ATP10A; ANO1; FXYD3; ATP13A; TTYH3B; TRDN; MCOLN2
    Stimuli-sensing channels TRPC4A; SGK2; CLIC2; TTYH2; TRDN; SLC9B2; FKBP1B; ANO10A; CLCNKA; TRPC5
    Transmembrane transport of small molecules SLC31A1; ABCC2; BSND; MMGT1; SLC5A8; SLC35A3; Ano3; SLC7A11; ATP7B; TTYH1

    ANO6 has several biochemical functions, for example, calcium activated cation channel activity, NOT intracellular calcium activated chloride channel activity, intracellular calcium activated chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANO6 itself. We selected most functions ANO6 had, and list some proteins which have the same functions with ANO6. You can find most of the proteins on our site.

    Function Related Protein
    calcium activated cation channel activity TRPM4; PKD2L1; CATSPER1; TMEM63C; CALHM1; TRPM5; ANO10; TRPM4C; ANO6; CATSPER2
    NOT intracellular calcium activated chloride channel activity ANO5; ANO8; ANO6; ANO10; ANO9; Ano3; ANO7
    intracellular calcium activated chloride channel activity ANO7; CLCA1; TTYH3; CLCA2; ANO2; ANO9; ANO6; ANO4; CLCA4; NMUR2
    phospholipid scramblase activity ANO4; ANO7; ANO6; ANO9; Ano3; PLSCR3; PLSCR1; PLSCR3A; PLSCR2; PLSCR3B
    protein binding FAM90A1; HESX1; AGO2; ANKRA2; FLCN; MYB; PHYH; FCRL4; ATE1; NCAM1A
    protein homodimerization activity UBE4A; CEBPB; Flt3l; CEACAM5; P2RX7; LSM1; RQCD1; TENM2; SYT16; SEPT12
    voltage-gated chloride channel activity CLCN4-2; CLCNKB; CLCNK; CLCN7; CLCN6; CLCN2; CLCNKA; CLCN1A; CLCN5; CLCN4
    voltage-gated ion channel activity CACNG2B; CLIC5; KCNK7; CLIC5B; TMEM109; CLIC6; KCNG4A; KCNB2; SCN8AB; CLIC4

    ANO6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANO6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANO6.


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