APCS

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APCS

Official Full Name amyloid P component, serum
Background The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
Synonyms APCS; amyloid P component, serum; SAP; PTX2; MGC88159; serum amyloid P-component; pentaxin-related; OTTHUMP00000024355; 9.5S alpha-1-glycoprotein
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human Serum
    • Mouse Serum
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human APCS-2526H Recombinant Human APCS protein, GST-tagged E.coli GST
    Human APCS-1269HCL Recombinant Human APCS cell lysate Human Cell N/A
    Human APCS-2311H Recombinant Human APCS Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human APCS-31189TH Native Human APCS N/A
    Human APCS-341H Recombinant Human APCS Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human APCS-674H Recombinant Human APCS protein, GST-tagged Wheat Germ GST
    Human APCS-72H Recombinant Human Amyloid P Component, Serum, T7-tagged E.coli T7
    Human APCS-8258H Native Human Serum Amyloid P Human Serum N/A
    Human APCS-8600H Recombinant Human APCS protein, His-tagged HEK293 His
    Human APCS-9734H Recombinant Human APCS, GST-tagged E.coli GST
    Mouse Apcs-1658M Recombinant Mouse Apcs Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse APCS-3089MCL Recombinant Mouse APCS cell lysate Human Cell N/A
    Mouse Apcs-4893M Mouse Apcs Reference serum Mouse Serum N/A
    Mouse Apcs-57M Mouse SAP Reference Standard N/A
    Mouse Apcs-585M Recombinant Mouse Apcs, His tagged Human Cell His
    Mouse APCS-728M Recombinant Mouse APCS Protein, His-tagged HEK293 His
    Rat APCS-1761RCL Recombinant Rat APCS cell lysate Human Cell N/A
    Rat Apcs-6863R Recombinant Rat Apcs, His tagged Human Cell His
    Rat Apcs-7095R Recombinant Rat Apcs protein, His-tagged E.coli His
    Rat Apcs-90R Rat SAP Reference Standard N/A

    APCS involved in several pathways and played different roles in them. We selected most pathways APCS participated on our site, such as Amyloid formation, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with APCS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amyloid formation CEACAM21; CALCA; MFGE8; CST3; APCS; TTR; NAT8B; HIST4H4; ODAM; RHBDL1
    Metabolism of proteins ASNA1; MGAT4A; LMAN2L; GRPEL1; PFDN5; MUC20; SLC30A6; DPH2; NAPAA; TOMM70A

    APCS has several biochemical functions, for example, calcium ion binding, carbohydrate binding, complement component C1q binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APCS itself. We selected most functions APCS had, and list some proteins which have the same functions with APCS. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding ANXA8; PITPNM3; KIAA0494; CAPN8; MYL6; PCDH1G30; PCDHGC4; C2CD4B; CDH7; VCANB
    carbohydrate binding VCAN; KLRA8; ASGR2; SIGLEC8; GALNT7; CLEC14A; Reg2; CNTN1; MAN2C1; LMAN2
    complement component C1q binding CD93; CALR; PTX3; C1QBP; C4A; CRP; APCS
    unfolded protein binding CCT6B; PFDN4; CCT6A; CALR3B; HSPA5; CALR3; TOR1A; PPIB; CCT2; HSP90B1
    virion binding APCS; CD209; HSP90B1; PVRL1; CLEC4M; PPIA; HIPK2; TSG101; PTX3

    APCS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APCS here. Most of them are supplied by our site. Hope this information will be useful for your research of APCS.

    GOT2; GK; GRB2; HES1; COPS5; d-mannose

    Veninga, H; Borg, EGF; et al. Antigen targeting reveals splenic CD169(+) macrophages as promoters of germinal center B-cell responses. EUROPEAN JOURNAL OF IMMUNOLOGY 45:747-757(2015).
    Zhang, Y; Hu, XY; et al. Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34:-(2015).

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