APEX2
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Official Full Name
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
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Overview
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5 to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). -
Synonyms
APEX2; APEX nuclease (apurinic/apyrimidinic endonuclease) 2; DNA-(apurinic or apyrimidinic site) lyase 2; APE2; APEXL2; XTH2; APEX nuclease 2; AP endonuclease 2; AP endonuclease XTH2; APEX nuclease-like 2; apurinic-apyrimidinic endonuclease 2; DNA-apurini;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- APEX2 Related Articles
APEX2 involved in several pathways and played different roles in them. We selected most pathways APEX2 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with APEX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | TDG.1;APEX2;nth;POLE2;HMGB1B;POLD2;LIG3;UNGA;HMGB1 |
APEX2 has several biochemical functions, for example, DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity, double-stranded DNA 3-5 exodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APEX2 itself. We selected most functions APEX2 had, and list some proteins which have the same functions with APEX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | SSH1;TOP1L;HOXD13A;SMARCAD1;ZNF37A;ZNF530;HOXB6A;ZNF224;EGR4 |
| DNA-(apurinic or apyrimidinic site) lyase activity | NEIL1;HMGA1;NEIL2;APEX1;ALKBH1;HMGA2;HMGA1B;HMGA1A;APEX2 |
| double-stranded DNA 3-5 exodeoxyribonuclease activity | APEX2;APEX1 |
| zinc ion binding | UQCRC1;TRIM35-27;MICAL1;HERC2;GDA;IRGF4;CREBBP;POLR2L;MT1X |
APEX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APEX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APEX2.
UBA1; UBE2N; UBE2V1; Map3k1; TRIM37; EFEMP2; TRAF2; CALCOCO2; CCDC85B; HOOK2; NINL; Pcna
- Q&As
- Reviews
Q&As (10)
Ask a questionThe APEX2 enables the detection of proteins by producing oxidation products and forming a stain in a visible range.
Recombinant APEX2 proteins are more sensitive and stable than other labeling technologies, allowing for labeling and detection in a shorter time.
APEX2 has the characteristics of high sensitivity, high specificity and rapid response, which is suitable for a variety of research and therapeutic needs.
APEX2 can be expressed and purified by genetic engineering technology.
The APEX2 applies detectable markers to the protein through oxidation reactions, enabling visual study of the target protein.
Recombinant APEX2 protein can be used as a tumor marker to help realize early diagnosis, treatment monitoring and prognosis assessment of cancer.
The effect of APEX2 s can usually be evaluated by comparing markers such as labeling effect, specificity, and sensitivity.
The recombinant APEX2 protein may have errors under certain conditions due to its special oxidation reaction mechanism.
Yes, APEX2 also has application potential in neurodegenerative diseases, cardiovascular diseases and other fields.
The recombinant APEX2 protein can be used clinically in the fields of labeling targeted drugs, tumor therapy and biosensors.
Customer Reviews (3)
Write a reviewAPEX2 produced by them has high expression and easy detection.
Maximizes the use of energy and resources by optimizing the production process and equipment.
The results are very consistent in each experiment or application, thanks to its high stability and reproducibility, which provides great convenience for follow-up studies.
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