|Official Full Name||Rho guanine nucleotide exchange factor (GEF) 28|
|Background||This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.|
|Synonyms||ARHGEF28; RIP2; RGNEF; p190RHOGEF; Rho guanine nucleotide exchange factor (GEF) 28; rho guanine nucleotide exchange factor 28; p190-RhoGEF; Rho interacting protein 2; rho-guanine nucleotide exchange factor; 190 kDa guanine nucleotide exchange factor|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
arhgef28 involved in several pathways and played different roles in them. We selected most pathways arhgef28 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with arhgef28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Axon guidance||PTK2; CLTB; DPYSL5B; KCNQ3; PLXNA3; ACTR3; GFRA1; RGMA; RND1; SEMA3AA|
|Developmental Biology||EFNA3B; SPRED1; EFNB1; INSM1B; KCNQ3; DNM1; CACNG2; SALL4; ITSN1; NR5A1|
|EPH-Ephrin signaling||EPHB4A; MYL9; EFNB3B; ACTR2B; EFNB2A; ARPC1A; EPHB3A; AP2A2; KALRN; CFL1|
|EPHB-mediated forward signaling||ITSN1; ARPC2; KALRNB; EFNB3; ACTR2; EFNB2; ARPC1A; EPHB3A; ACTR3; EFNB1|
|Regulation of RhoA activity||ARHGAP9; ARHGEF25; PLEKHG6; NET1; MCF2L; ARAP1; OBSCN; ARHGEF28; ARHGEF10; DEF6|
|Signaling events mediated by focal adhesion kinase||KLF8; ARHGEF28; ARHGAP26; ACTA1; BMX|
arhgef28 has several biochemical functions, for example, RNA binding, Rho guanyl-nucleotide exchange factor activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by arhgef28 itself. We selected most functions arhgef28 had, and list some proteins which have the same functions with arhgef28. You can find most of the proteins on our site.
|RNA binding||CSDC2; RDBP; PKZ; RPL31; U2AF2A; RAVER2; SETD1B; MRPL12; KIAA0907; DIS3L|
|Rho guanyl-nucleotide exchange factor activity||ARHGEF9B; ARHGEF33; DCLRE1B; ARHGEF17; DOCK11; ARHGEF7; ARHGEF10; PLEKHG5; DNMBP; FGD4A|
|metal ion binding||POGZA; CFI; GTF2E1; ITGAL; ZNF718; HINFP; TAX1BP1B; ZFP64; CYP19A1A; ZFYVE27|
arhgef28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with arhgef28 here. Most of them are supplied by our site. Hope this information will be useful for your research of arhgef28.