ARPP21
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Official Full Name
cAMP-regulated phosphoprotein, 21kDa
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Overview
The 21-kD cAMP-regulated phosphoprotein (ARPP21), also known as regulator of calmodulin (CaM; MIM 114180) signaling (RCS), plays a central role in integration of key neurotransmitter inputs into medium spiny neurons through its regulation of CaM-dependent kinase I (CaMKI) and protein phosphatase-2B (PP2B) (Rakhilin et al., 2004 -
Synonyms
ARPP21; cAMP-regulated phosphoprotein, 21kDa; cAMP-regulated phosphoprotein 21; ARPP 21; R3H domain containing 3; R3HDM3; TARPP; thymocyte cAMP-regulated phosphoprotein; cyclic AMP-regulated phosphoprotein, 21 kD; RCS; ARPP-21; FLJ32997;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ARPP21-9890H | Recombinant Human ARPP21, GST-tagged | E.coli | GST | 1-89a.a. | |
| Human | ARPP21-8680HCL | Recombinant Human ARPP21 293 Cell Lysate | HEK293 | N/A |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ARPP21 Related Articles
ARPP21 involved in several pathways and played different roles in them. We selected most pathways ARPP21 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPP21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ARPP21 has several biochemical functions, for example, calmodulin binding, molecular_function, nucleic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPP21 itself. We selected most functions ARPP21 had, and list some proteins which have the same functions with ARPP21. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | RYR1;PHKA2;DCX;PNCK;TTN;MYO1C;TJP1;CNN2;IQGAP3 |
| molecular_function | VWA3A;CCDC187;TNNI1AL;LMBRD2B;LEPROTL1;FAM177A;RPL41;KIAA0247;BCL7BA |
| nucleic acid binding | ALYREF;ZCCHC2;ZFP524;ZCCHC10;SF3B6;ZFP771;ZFP932;ZSCAN2;PRDM12B |
ARPP21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPP21 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPP21.
TERF1; TERF2IP
- Q&As
- Reviews
Q&As (7)
Ask a questionCurrently, there are no specific drugs or compounds known to directly modulate ARPP21 activity. Future research may identify potential compounds that could target ARPP21 for therapeutic purposes.
ARPP21 is expressed in various cell types, including neurons in the brain. However, its expression pattern in different tissues and organs throughout the body is not well characterized.
At this point, there is no specific information linking ARPP21 dysfunction to any particular diseases or disorders. However, further research is needed to fully understand its role and potential implications.
Currently, there is no direct evidence suggesting that ARPP21 can be targeted for therapeutic purposes. However, continued research may reveal its potential as a target for certain conditions in the future.
Researchers are exploring the functions and mechanisms of ARPP21, its role in synaptic plasticity and cognitive processes, as well as its potential involvement in neurological disorders such as schizophrenia and addiction.
Yes, some studies suggest that ARPP21 interacts with other molecules or proteins involved in cellular signaling pathways, such as protein phosphatase 2A (PP2A), which is involved in regulating protein phosphorylation.
To find more information about ARPP21 and its current research, you can refer to scientific journals, databases like PubMed, or academic websites specializing in neuroscience or protein research.
Customer Reviews (3)
Write a reviewIts high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.
The ARPP21 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.
Whether measuring analyte concentrations, screening for specific interactions, or monitoring immune responses, this protein's exceptional performance in ELISA experiments is truly commendable.
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