ARSE
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Official Full Name
arylsulfatase E (chondrodysplasia punctata 1)
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Overview
Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. -
Synonyms
ARSE; arylsulfatase E (chondrodysplasia punctata 1); CDPX, CDPX1; arylsulfatase E; chondrodysplasia punctata 1; CDPX; CDPX1; CDPXR; MGC163310; OTTHUMP00000022851; ASE;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc|DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ARSE-863H | Recombinant Human ARSE protein, GST-tagged | Wheat Germ | GST | ||
Human | ARSE-3661H | Recombinant Human ARSE, His-tagged | E.Coli or Yeast | His | 589 | |
Human | ARSE-38HCL | Recombinant Human ARSE lysate | HEK293 | N/A | ||
Human | ARSE-2824H | Recombinant Human ARSE Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | ARSE-1292HF | Recombinant Full Length Human ARSE Protein, GST-tagged | In Vitro Cell Free System | GST | 589 amino acids | |
Cynomolgus Monkey | ARSE-313C | Recombinant Cynomolgus ARSE Protein, His-tagged | Mammalian Cell | His | ||
Cynomolgus Monkey | ARSE-63C | Recombinant Cynomolgus Monkey ARSE Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Cynomolgus Monkey | ARSE-63C-B | Recombinant Cynomolgus Monkey ARSE Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- ARSE Related Articles
ARSE involved in several pathways and played different roles in them. We selected most pathways ARSE participated on our site, such as Estrogen metabolism, Gamma carboxylation, hypusine formation and arylsulfatase activation, Glycosphingolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARSE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Estrogen metabolism | NQO1;ARSE;ARSD;CYP1A1;COMT;CYP1B1 |
Gamma carboxylation, hypusine formation and arylsulfatase activation | DHPS;EIF5A2;SUMF2;EIF5A;ARSJ;ATPBD4;EEF2;DPH1;ARSE |
Glycosphingolipid metabolism | ARSH;GLTPA;ARSJ;SUMF2;CPTP;GLTP;ARSI;NEU3;GLB1L |
Metabolism | SLC27A2A;C2orf56;ATP5S;SLC5A9;NDUFAF3;CYP2Y3;SLC35B2;GLYATL2;CIAPIN1 |
Metabolism of lipids and lipoproteins | PLD6;HSD17B11;CYP46A1;CYP27B1;ARSI;CERS4A;CERS3B;ARF3;FA2H |
Metabolism of proteins | TBCD;GRP;YKT6;CDX2;SLC25A13;TIMM17B;TIMM8A;EXOC3;LMAN2L |
Post-translational protein modification | MCFD2;TRAPPC2;EID3;NAPAA;DPH5;MGAT4B;ADAMTS13;TRAPPC5;ADAMTS15 |
Sphingolipid metabolism | CPTP;ACER3;NEU1;ASAH1;SMPD2;SERINC1;GAL3ST1A;DEGS1;GLTP |
ARSE has several biochemical functions, for example, arylsulfatase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARSE itself. We selected most functions ARSE had, and list some proteins which have the same functions with ARSE. You can find most of the proteins on our site.
Function | Related Protein |
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arylsulfatase activity | ARSI;ARSD;SULF1;ARSJ;SULF2;ARSF;ARSH;ARSB;ARSK |
metal ion binding | GALNTL2;PFKMA;STAC3;DMRT3;MGRN1A;AMDHD1;ZFP536;NAIP6;ZNF557 |
ARSE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARSE here. Most of them are supplied by our site. Hope this information will be useful for your research of ARSE.
TNK2; TMEM259; NDN; COQ6
- Q&As
- Reviews
Q&As (7)
Ask a questionCurrently, there is no cure for X-linked chondrodysplasia punctata (CDPX1). Treatment focuses on managing the symptoms and providing supportive care. Physical therapy, medications, and surgical interventions may be recommended based on individual needs and associated complications.
Mutations in the ARSE gene can lead to a deficiency or reduced activity of the ARSE enzyme. This can result in a rare genetic disorder known as X-linked chondrodysplasia punctata (CDPX1), which primarily affects skeletal development and can manifest with characteristic bone and cartilage abnormalities.
X-linked chondrodysplasia punctata (CDPX1) is inherited in an X-linked recessive manner. This means that the condition primarily affects males, who have one X chromosome, while females can be carriers of the disease unless both their X chromosomes are affected.
Yes, variations or mutations in the ARSE protein can impact its catalytic efficiency. Certain mutations may reduce or abolish the enzymatic activity of ARSE, resulting in a deficiency of the enzyme and impaired breakdown of sulfated GAGs.
Yes, genetic counseling can be highly beneficial for families with X-linked chondrodysplasia punctata (CDPX1) or ARSE gene mutations. Genetic counselors can provide information about the condition, inheritance patterns, prenatal testing options, and available support resources. They can also help families understand the risk of passing on the mutation and make informed decisions regarding family planning.
Yes, X-linked chondrodysplasia punctata (CDPX1) is the main disorder associated with mutations in the ARSE gene. It is characterized by skeletal abnormalities, developmental delays, characteristic facial features, and other symptoms that can vary in severity.
The activity of the ARSE protein can be regulated through various mechanisms. One such mechanism is the presence of specific cofactors or activators that can enhance ARSE activity. Additionally, the expression of the ARSE gene itself can be controlled by genetic and epigenetic factors.
Customer Reviews (3)
Write a reviewThe ARSE protein is highly recommended for its exceptional performance in ELISA assays.
The bands of proteins in Western Blotting experiments were very clear.
The ARSE protein's excellent performance in ELISA ensures accurate and reproducible results, enhancing the reliability of experimental data.
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