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ARSE

  • Official Full Name

    arylsulfatase E (chondrodysplasia punctata 1)

  • Overview

    Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene.
  • Synonyms

    ARSE; arylsulfatase E (chondrodysplasia punctata 1); CDPX, CDPX1; arylsulfatase E; chondrodysplasia punctata 1; CDPX; CDPX1; CDPXR; MGC163310; OTTHUMP00000022851; ASE;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARSE-863H Recombinant Human ARSE protein, GST-tagged Wheat Germ GST
Human ARSE-3661H Recombinant Human ARSE, His-tagged E.Coli or Yeast His 589
Human ARSE-38HCL Recombinant Human ARSE lysate HEK293 N/A
Human ARSE-2824H Recombinant Human ARSE Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ARSE-1292HF Recombinant Full Length Human ARSE Protein, GST-tagged In Vitro Cell Free System GST 589 amino acids
Cynomolgus Monkey ARSE-313C Recombinant Cynomolgus ARSE Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ARSE-63C Recombinant Cynomolgus Monkey ARSE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ARSE-63C-B Recombinant Cynomolgus Monkey ARSE Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARSE Related Articles

ARSE involved in several pathways and played different roles in them. We selected most pathways ARSE participated on our site, such as Estrogen metabolism, Gamma carboxylation, hypusine formation and arylsulfatase activation, Glycosphingolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARSE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Estrogen metabolismNQO1;ARSE;ARSD;CYP1A1;COMT;CYP1B1
Gamma carboxylation, hypusine formation and arylsulfatase activationDHPS;EIF5A2;SUMF2;EIF5A;ARSJ;ATPBD4;EEF2;DPH1;ARSE
Glycosphingolipid metabolismARSH;GLTPA;ARSJ;SUMF2;CPTP;GLTP;ARSI;NEU3;GLB1L
MetabolismSLC27A2A;C2orf56;ATP5S;SLC5A9;NDUFAF3;CYP2Y3;SLC35B2;GLYATL2;CIAPIN1
Metabolism of lipids and lipoproteinsPLD6;HSD17B11;CYP46A1;CYP27B1;ARSI;CERS4A;CERS3B;ARF3;FA2H
Metabolism of proteinsTBCD;GRP;YKT6;CDX2;SLC25A13;TIMM17B;TIMM8A;EXOC3;LMAN2L
Post-translational protein modificationMCFD2;TRAPPC2;EID3;NAPAA;DPH5;MGAT4B;ADAMTS13;TRAPPC5;ADAMTS15
Sphingolipid metabolismCPTP;ACER3;NEU1;ASAH1;SMPD2;SERINC1;GAL3ST1A;DEGS1;GLTP

ARSE has several biochemical functions, for example, arylsulfatase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARSE itself. We selected most functions ARSE had, and list some proteins which have the same functions with ARSE. You can find most of the proteins on our site.

Function Related Protein
arylsulfatase activityARSI;ARSD;SULF1;ARSJ;SULF2;ARSF;ARSH;ARSB;ARSK
metal ion bindingGALNTL2;PFKMA;STAC3;DMRT3;MGRN1A;AMDHD1;ZFP536;NAIP6;ZNF557

ARSE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARSE here. Most of them are supplied by our site. Hope this information will be useful for your research of ARSE.

TNK2; TMEM259; NDN; COQ6

Bourre-Tessier, J; Urowitz, MB; et al. Electrocardiographic Findings in Systemic Lupus Erythematosus: Data From an International Inception Cohort. ARTHRITIS CARE & RESEARCH 67:128-135(2015).
Hogema, BM; Molier, M; et al. Past and present of hepatitis E in the Netherlands. TRANSFUSION 54:3092-3096(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
Is there any treatment available for X-linked chondrodysplasia punctata (CDPX1)? 03/03/2020

Currently, there is no cure for X-linked chondrodysplasia punctata (CDPX1). Treatment focuses on managing the symptoms and providing supportive care. Physical therapy, medications, and surgical interventions may be recommended based on individual needs and associated complications.

What happens if there is a mutation in the ARSE gene? 05/26/2019

Mutations in the ARSE gene can lead to a deficiency or reduced activity of the ARSE enzyme. This can result in a rare genetic disorder known as X-linked chondrodysplasia punctata (CDPX1), which primarily affects skeletal development and can manifest with characteristic bone and cartilage abnormalities.

How is X-linked chondrodysplasia punctata (CDPX1) inherited? 06/17/2018

X-linked chondrodysplasia punctata (CDPX1) is inherited in an X-linked recessive manner. This means that the condition primarily affects males, who have one X chromosome, while females can be carriers of the disease unless both their X chromosomes are affected.

Can variations in the ARSE protein affect its catalytic efficiency? 07/18/2017

Yes, variations or mutations in the ARSE protein can impact its catalytic efficiency. Certain mutations may reduce or abolish the enzymatic activity of ARSE, resulting in a deficiency of the enzyme and impaired breakdown of sulfated GAGs.

Can genetic counseling be beneficial for families with X-linked chondrodysplasia punctata (CDPX1) or ARSE gene mutations? 03/08/2017

Yes, genetic counseling can be highly beneficial for families with X-linked chondrodysplasia punctata (CDPX1) or ARSE gene mutations. Genetic counselors can provide information about the condition, inheritance patterns, prenatal testing options, and available support resources. They can also help families understand the risk of passing on the mutation and make informed decisions regarding family planning.

Are there any known diseases associated with ARSE mutations? 10/09/2016

Yes, X-linked chondrodysplasia punctata (CDPX1) is the main disorder associated with mutations in the ARSE gene. It is characterized by skeletal abnormalities, developmental delays, characteristic facial features, and other symptoms that can vary in severity.

How is the activity of the ARSE protein regulated? 09/13/2016

The activity of the ARSE protein can be regulated through various mechanisms. One such mechanism is the presence of specific cofactors or activators that can enhance ARSE activity. Additionally, the expression of the ARSE gene itself can be controlled by genetic and epigenetic factors.

Customer Reviews (3)

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Reviews
03/21/2018

    The ARSE protein is highly recommended for its exceptional performance in ELISA assays.

    01/17/2018

      The bands of proteins in Western Blotting experiments were very clear.

      12/02/2016

        The ARSE protein's excellent performance in ELISA ensures accurate and reproducible results, enhancing the reliability of experimental data.

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