ASB3
-
Official Full Name
ankyrin repeat and SOCS box containing 3
-
Overview
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. -
Synonyms
ASB3; ankyrin repeat and SOCS box containing 3; ankyrin repeat and SOCS box protein 3; ASB 3; Ankyrin repeat and SOCS box containing protein 3; ASB-3; ASB3_HUMAN; FLJ10123; FLJ10421; MGC12531; MGC132002; MGC996; Weakly similar to ankyrin brain variant 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
ASB3 involved in several pathways and played different roles in them. We selected most pathways ASB3 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | HLA-DQB2;CMTM2A;IGKC;MGC174155;IFI30;KLHL20;LILRA3;ASB18;RNF123 |
| Antigen processing: Ubiquitination & | UBE2E3;UFL1;RNF41;RNF111;FBXO3;RNF34;UBE2F;ASB10;RNF123 |
| Proteasome degradation | WWP1;ASB10;UBE2J2;MKRN1;SPSB4;PJA1;RNF41;TRIM9;RNF220 |
| Class I MHC mediated antigen processing & | CMTM2A;RNF41;UBE2L6;RNF6;ERAP2;TRIM41;TPP2;KLHL21;ASB17 |
| presentation | CMTM2A;TPP2;WSB1;RNF6;LRRC41;TRIM50;FBXO17;STUB1;CYBB |
| Immune System | TXNIPA;ARIH1L;SIGLEC9;DEFA6;TRIM68;RACGAP1;HBL3;LTF;HLA-DQB2 |
ASB3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASB3 itself. We selected most functions ASB3 had, and list some proteins which have the same functions with ASB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MED28;DCTN4;RCHY1;FHIT;MAGEB18;KIAA1967;MICALL2;JAGN1;C1orf21 |
ASB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASB3.
SH2D2A; HSP90AB1; KDM1A; ZAP70; TNS2; RIN3; eno; PRMT6
- Q&As
- Reviews
Q&As (7)
Ask a questionYes, ASB3 has been shown to interact with several proteins, including Cullin 5, Elongin BC complex, and the E3 ubiquitin ligase complex, among others.
ASB3 has been reported to target proteins such as Notch1, Smurf1, and Fanconi anemia-associated protein FANCC for ubiquitination and subsequent degradation.
ASB3 is involved in regulating various pathways, including the Notch signaling pathway, TGF-β signaling pathway, and Wnt/β-catenin signaling pathway, among others.
Currently, there are no known small molecules or drugs specifically targeting ASB3 activity, but further research may unveil potential therapeutic interventions.
Yes, various genetic variations and polymorphisms in the ASB3 gene have been identified, some of which have been associated with certain diseases and conditions.
Mutations in the ASB3 gene have been found in individuals with intellectual disability and developmental delay, suggesting a potential role in these disorders.
The regulation of ASB3 expression by environmental factors is not well-documented. More research is needed to investigate this aspect.
Customer Reviews (3)
Write a reviewIts versatility and reliability make it a great asset in the pursuit of scientific discoveries.
With the ASB3 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.
Its exceptional properties and reliable results make it a valuable tool in various experimental applications.
Ask a Question for All ASB3 Products
Required fields are marked with *
My Review for All ASB3 Products
Required fields are marked with *
