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ASB4

  • Official Full Name

    ankyrin repeat and SOCS box containing 4

  • Overview

    The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.
  • Synonyms

    ASB4; ankyrin repeat and SOCS box containing 4; ankyrin repeat and SOCS box protein 4; ASB 4; Ankyrin repeat and SOCS box containing protein 4; ankyrin repeat and SOCS box-containing 4; ASB-4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ASB4-893H Recombinant Human ASB4 protein, GST-tagged Wheat Germ GST
Human ASB4-8662HCL Recombinant Human ASB4 293 Cell Lysate HEK293 N/A
Human ASB4-8663HCL Recombinant Human ASB4 293 Cell Lysate HEK293 N/A
Human ASB4-1296HF Recombinant Full Length Human ASB4 Protein, GST-tagged In Vitro Cell Free System GST 319 amino acids
Mouse ASB4-2016M Recombinant Mouse ASB4 Protein Mammalian Cell His
Mouse ASB4-779M Recombinant Mouse ASB4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ASB4-779M-B Recombinant Mouse ASB4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ASB4-2399Z Recombinant Zebrafish ASB4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ASB4 involved in several pathways and played different roles in them. We selected most pathways ASB4 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemAP1S1;CTSB;KIF22;RNF138;CLEC2B;GAN;STUB1;KIFAP3;RAET1E
Antigen processing: Ubiquitination &ampRNF25;NPEPPS;TRIM69;TRIM41;FBXO27;ASB18;SPSB4;FBXO3;RNF34
Proteasome degradationKLHL20;RNF19B;UBA5;ATG7;ASB3;ASB6;ASB11;ASB10;ARIH2
Class I MHC mediated antigen processing &ampUBE2F;FBXO44;CD207;ASB6;UBE2V2;RNF123;FCGR1B;TPP2;GAN
presentationTPP2;SEC24A;RNF123;NPEPPS;HECTD3;UBR2;LTN1;STUB1;TRIM11
Immune SystemPPIAL4A;PAG1;DEFB4B;LILRB2;CD180;TNFSF13B;LAIR2;NCKAP1;BAIAP2

ASB4 has several biochemical functions, for example, ubiquitin protein ligase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASB4 itself. We selected most functions ASB4 had, and list some proteins which have the same functions with ASB4. You can find most of the proteins on our site.

Function Related Protein
ubiquitin protein ligase activityRNF34;MED24;FBXW11;TRIM72;BTRC;ARIH2;UBE2O;HECTD2;SIAH2L
ubiquitin protein ligase bindingUCHL1;GLMN;SMAD2;IKBKE;FBXW7;UBE2T;CUL3A;VCL;TCEB2

ASB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASB4.

HSP90AB1

  • Q&As
  • Reviews

Q&As (10)

Ask a question
Can ASB4 regulate the degradation of specific target proteins? 03/02/2023

Yes, ASB4 interacts with specific target proteins, recognizing them and facilitating their ubiquitination, leading to their subsequent degradation.

Can ASB4 have both cytoplasmic and nuclear functions? 02/19/2023

Yes, ASB4 has been observed in both the cytoplasm and the nucleus, suggesting its involvement in diverse cellular compartments and functions.

Is the ASB4 protein conserved across different species? 07/13/2017

Yes, ASB4 shows evolutionary conservation, indicating its functional importance across various species.

Does ASB4 have any known substrate specificity? 07/07/2017

Yes, ASB4 selectively targets certain proteins for degradation, usually by recognizing specific recognition motifs or interacting with other regulatory factors.

Are there any known interacting proteins that modulate ASB4 activity? 04/12/2017

ASB4 can interact with various proteins, including its ubiquitin ligase complex partners or substrate proteins, influencing its activity, localization, or substrate specificity.

Are there any diseases or disorders associated with ASB4 dysfunction? 11/06/2016

Currently, there are no known diseases or disorders directly linked to ASB4 dysfunction. However, its dysregulation may potentially contribute to various pathological conditions, requiring further investigation.

What are some of the cellular processes influenced by ASB4-mediated protein degradation? 11/02/2016

ASB4-mediated protein degradation can impact cellular processes such as gene expression, signal transduction, cell proliferation, and differentiation.

Can ASB4 play a role in muscle development or function? 09/07/2016

Yes, ASB4 has been implicated in skeletal muscle development, differentiation, and regeneration processes based on experimental evidence and studies in animal models.

Are there any drugs or therapeutic interventions targeting ASB4? 07/25/2016

Presently, there are no specific drugs targeting ASB4. However, understanding its role and identifying potential modulators may open avenues for therapeutic interventions in the future.

Does ASB4 expression respond to external signals or stimuli? 02/04/2016

Yes, ASB4 expression can be regulated by external signals, including hormones, cytokines, growth factors, and cellular stress.

Customer Reviews (3)

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Reviews
01/30/2023

    The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.

    07/27/2020

      the ASB4 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.

      04/03/2016

        Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.

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