ASB7
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Official Full Name
ankyrin repeat and SOCS box containing 7 -
Overview
The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. -
Synonyms
ASB7;ankyrin repeat and SOCS box containing 7;ankyrin repeat and SOCS box protein 7;Ankyrin repeat and SOCS box containing protein 7;ASB 7;ASB-7;ankyrin repeat and SOCS box-containing 7
Recombinant Proteins
- Zebrafish
- Chicken
- Mouse
- Rhesus macaque
- Human
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
ASB7 involved in several pathways and played different roles in them. We selected most pathways ASB7 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASB7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class I MHC mediated antigen processing & | UBR1,UBE2J2,ASB6,CD207,RNF220,SEC24A,SPSB1,DTX3L,SPSB4,FCGR1B |
| Immune System | EIF4G2A,PANX1,SPSB4,SIGLEC7,KPNA4,TRIM31,CLEC4D,CR1,KIF5A,CTSLL |
| Antigen processing: Ubiquitination & | ARIH2,STUB1,UBE2L6,RNF14,NPEPPS,ASB17,RNF111,UBE2F,TRIM39,GAN |
| Proteasome degradation | ASB3,LTN1,ASB4,RNF25,TRAF7,GAN,RNF6,ASB11,ASB6,STUB1 |
| presentation | SEC23A,MKRN1,SPSB2,RBCK1,TRIM39,ASB10,RNF144B,CYBB,CMTM2A,UBE2V1 |
| Adaptive Immune System | SPSB4,AP2A1,RNF14,ITGB1B.1,HLA-DQB2,AGO3,ARIH2,OSCAR,ASB6,CTSS |
Protein Function
ASB7 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASB7 itself. We selected most functions ASB7 had, and list some proteins which have the same functions with ASB7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KCNJ10,ATG13,KRT5,PARK2,FANCI,FAM109A,HPCAL4,FKBP6,ASCL1,FGF19 |
Interacting Protein
ASB7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASB7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASB7.
HMBOX1;CCDC136;CUL5;RNF7;ATF4
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References
- Zhang, LF; Zhou, X; et al. Genome Wide Screening of Candidate Genes for Improving Piglet Birth Weight Using High and Low Estimated Breeding Value Populations. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 10:236-244(2014).
- Baxter, SS; Carlson, LA; et al. Granulocytic differentiation of HL-60 promyelocytic leukemia cells is associated with increased expression of Cul5. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 45:264-274(2009).
