Atg12

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Atg12

Official Full Name ATG12 autophagy related 12 homolog
Background Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 (PubMed 9852036)).
Synonyms ATG12; ATG12 autophagy related 12 homolog (S. cerevisiae); Apg12 (autophagy 12, S. cerevisiae) like , APG12 autophagy 12 like (S. cerevisiae) , APG12L; ubiquitin-like protein ATG12; APG12; APG12 autophagy 12 like; autophagy-related protein 12; Apg12 (aut
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATG12-8626HCL Recombinant Human ATG12 293 Cell Lysate HEK293 N/A
    Human ATG12-943H Recombinant Human ATG12 protein, GST-tagged Wheat Germ GST
    Mouse Atg12-1523M Recombinant Mouse Autophagy-Related 12 (Yeast), His-tagged E.coli His
    Mouse ATG12-2074M Recombinant Mouse ATG12 Protein Mammalian Cell His
    Rat ATG12-842R Recombinant Rat ATG12 Protein Mammalian Cell His
    Zebrafish ATG12-8093Z Recombinant Zebrafish ATG12 Mammalian Cell His

    Atg12 involved in several pathways and played different roles in them. We selected most pathways Atg12 participated on our site, such as FoxO signaling pathway, Regulation of autophagy, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Atg12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway MAPK1; CCNB2; MAPK12; PIK3R3; MAPK12A; PTENA; PRKAG3; PIK3CD; GRB2A; INSB
    Regulation of autophagy ULK3; ATG5; PRKAA1; ATG3; ULK2; Ifna15; BECN1; GABARAPL1; IFNA1; GABARAP
    RIG-I-like receptor signaling pathway IFNB1; IL8L1; TRAF2; TBK1; OTUD5A; CXCL8B.3; IFNA1; MAPK12; ATG5; IFNA16

    Atg12 has several biochemical functions, for example, Atg8 ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Atg12 itself. We selected most functions Atg12 had, and list some proteins which have the same functions with Atg12. You can find most of the proteins on our site.

    Function Related Protein
    Atg8 ligase activity ATG12; ATG3
    protein binding KCNA2; C9orf78; NDE1; NTF4; CLASP1; GRIN1; SRSF7; ABCF3; SCRN2; TOB1

    Atg12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Atg12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Atg12.

    ATG5; ATG16L1; ATG3; CRX; 21362046; SF3B1; POP7; GABARAP

    Li, B; Yue, Y; et al. Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 32:705-714(2014).
    Otabe, H; Nibuya, M; et al. Electroconvulsive seizures enhance autophagy signaling in rat hippocampus. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 50:37-43(2014).

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