ATP6V0B

  • Official Full Name

    ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

  • Overview

    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
  • Synonyms

    ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b; ATP6F, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21kD , ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c; V-type proton ATPase 21 kDa proteolipid subunit; HATPL; VMA16; ATP6F; V-ATPase 21 kDa proteolipid subunit; Vacuolar proton pump 21 kDa proteolipid subunit; VATO_HUMAN; V-ATPase subunit c; vacuolar proton pump, 21 kDa subunit; H(+)-transporting two-sector ATPase, subunit F; vacuolar ATP synthase 21 kDa proteolipid subunit;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Rhesus Macaque
  • Zebrafish
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6V0B-149HCL Recombinant Human ATP6V0B cell lysate N/A
Bos taurus (Bovine) RFL27335BF Recombinant Full Length Bovine V-Type Proton Atpase 21 Kda Proteolipid Subunit(Atp6V0B) Protein, His-Tagged E.coli expression system His Full Length (1-205)
Homo sapiens (Human) RFL9681HF Recombinant Full Length Human V-Type Proton Atpase 21 Kda Proteolipid Subunit(Atp6V0B) Protein, His-Tagged E.coli expression system His Full Length (1-205)
Mus musculus (Mouse) RFL929MF Recombinant Full Length Mouse V-Type Proton Atpase 21 Kda Proteolipid Subunit(Atp6V0B) Protein, His-Tagged E.coli expression system His Full Length (1-205)
Rhesus Macaque ATP6V0B-464R Recombinant Rhesus monkey ATP6V0B Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATP6V0B-293R-B Recombinant Rhesus Macaque ATP6V0B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP6V0B-293R Recombinant Rhesus Macaque ATP6V0B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ATP6V0B-9964Z Recombinant Zebrafish ATP6V0B Mammalian Cell His
Chicken ATP6V0B-4958C Recombinant Chicken ATP6V0B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ATP6V0B involved in several pathways and played different roles in them. We selected most pathways ATP6V0B participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationNDUFA7;ATP6AP2;ATP6V0D1;NDUFC2-KCTD14;ATP5IB;ATP6V0E;ATP5D;COX17;NDUFS8
Metabolic pathwaysTPI1A;ACSM5;HK1;PLA2G4A;MAT2B;BCMO1;AADAT;MAPK1IP1L;TALDO1
LysosomeNAGPA;HEXA;HEXB;DNASE2A;FAM49BA;CTPS1B;ACP5B;ASAH1;LAMP3
PhagosomeMBL1;FCGR3A;ATP6AP1;RAB7A;BLB2;ABCB3L1;MSR1;FCGR4;RAB5C
Synaptic vesicle cycleNSF;SLC17A8;CPLX2;SLC17A6;UNC13A;ATP6V1C1;STXBP1;ATP6V1F;SNAP25
Vibrio cholerae infectionACTG1;ATP6V0B;ATP6V1E2;KDELR2;ATP6V0A1;ATP6V0D1;ATP6V1G2;ATP6V1D;SEC61G
Epithelial cell signaling in Helicobacter pylori infectionGIT1;ATP6V0B;RELA;MAP2K4;MAPK10;ATP6V1F;MAPK13;JAM3;RAC1
TuberculosisIL6;ATP6V0A2;NFYB;IFNA8;Ifna11;IL12A;HLA-DQA1;SYK;IRAK4
Rheumatoid arthritisATP6V0A2;ITGAL;ATP6V1G2;ATP6V0E1;ATP6V1B2;CD80;HLA-DPA1;CCL3L1;ATP6V1D

ATP6V0B has several biochemical functions, for example, proton-transporting ATPase activity, rotational mechanism, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0B itself. We selected most functions ATP6V0B had, and list some proteins which have the same functions with ATP6V0B. You can find most of the proteins on our site.

Function Related Protein
proton-transporting ATPase activity, rotational mechanismATP6V1E2;ATP6V1AA;ATP6V0A4;TCIRG1;ATP6V1E1;ATP5D;ATP6V0CB;ATP6V0B;ATP6V1C1
transporter activityABCG2;CLVS2;AQP3B;LCN2;SLCO1F2;FLR;SYPA;SLC2A11L;TIMM9

ATP6V0B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0B.

FAS; YWHAG; IRAK3

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