ATXN2L
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Official Full Name
ataxin 2-like
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Overview
This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. -
Synonyms
ATXN2L; ataxin 2-like; ataxin-2-like protein; A2D; A2lp; A2LG; A2RP; Ataxin 2 domain protein; Ataxin 2 like; Ataxin 2 like protein; Ataxin 2 related protein; Ataxin-2 domain protein; Ataxin-2 like; Ataxin-2-related protein; ATX2L_HUMAN; ATXN2L ataxin 2 like;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | ATXN2L-819H | Recombinant Human ATXN2L Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | ATXN2L-3038H | Recombinant Human ATXN2L Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Mouse | ATXN2L-2196M | Recombinant Mouse ATXN2L Protein | Mammalian Cell | His |
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| Mouse | ATXN2L-902M | Recombinant Mouse ATXN2L Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | Atxn2l-1784M | Recombinant Mouse Atxn2l Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Mouse | ATXN2L-902M-B | Recombinant Mouse ATXN2L Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | ATXN2L-11960Z | Recombinant Zebrafish ATXN2L | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
ATXN2L involved in several pathways and played different roles in them. We selected most pathways ATXN2L participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ATXN2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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ATXN2L has several biochemical functions, for example, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATXN2L itself. We selected most functions ATXN2L had, and list some proteins which have the same functions with ATXN2L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | HNRNPR;CHST13;HSPD1;RBM4;PABPN1;GNL2;ZCCHC3;HNRNPAB;RPP30 |
ATXN2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATXN2L here. Most of them are supplied by our site. Hope this information will be useful for your research of ATXN2L.
Hmga2; Ywhae; Tmem173
- Q&As
- Reviews
Q&As (7)
Ask a questionAt present, the relationship between ATXN2L protein and nervous system diseases is not fully understood. However, some studies have shown that the mutation or abnormal expression of ATXN2L protein may lead to the dysfunction of this protein in cells, thereby affecting the normal function of nerve cells.
The regulation of ATXN2L protein function involves multiple levels. For example, its expression levels can be influenced by transcription factors and RNA splicing regulation. In addition, it interacts with other proteins to form complexes involved in the regulation of cellular processes.
Current studies have shown that ATXN2L protein is associated with multiple disease processes. For example, it is associated with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease. In addition, ATXN2L protein may also be related to the occurrence and progression of malignant tumors such as breast cancer and lung cancer.
ATXN2L protein has multiple functions in cells. It is involved in the regulation of mRNA translation, RNA transport and cell adhesion, and may also play a role in the regulation of neural development and synaptic function.
It contains multiple conserved domains, the most prominent of which is RNA recognition motifs (RRMs). These domains may be related to their involvement in RNA recognition and binding functions.
ATXN2L protein is expressed in several tissues, but its expression is higher in the nervous system. In addition, ATXN2L expression was also detected in liver, lung, heart and other tissues.
ATXN2L gene mutations have been found to be associated with ALS. Several specific ATXN2L mutations have been implicated in the pathogenesis of familial and sporadic ALS. These mutations may lead to the abnormal expression or function of ATXN2L protein, and then affect the normal function of nerve cells.
Customer Reviews (3)
Write a reviewThe stability of ATXN2L means that we can store it and use it at any time without fear of its inactivation or deterioration.
ATXN2L significantly improved the reproducibility of Western blotting.
The purity of ATXN2L is very high, which can ensure the safety of the experiment and also avoid unnecessary risks.
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