Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

BAG4

Official Full Name

BCL2-associated athanogene 4
Overview

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Synonyms

BAG4; BCL2-associated athanogene 4; BAG family molecular chaperone regulator 4; silencer of death domains; SODD; bcl-2-associated athanogene 4; BAG-family molecular chaperone regulator-4; BAG-4; DKFZp586O2022;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His|T7
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BAG4-055H	Recombinant Human BAG4 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	BAG4-8526HCL	Recombinant Human BAG4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	BAG4-4771H	Recombinant Human BAG4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	BAG4-1803HF	Recombinant Full Length Human BAG4 Protein, GST-tagged	In Vitro Cell Free System	GST	457 amino acids	Inquiry
Mouse	Bag4-1421M	Recombinant Mouse Bag4 protein, His & T7-tagged	E.coli	His/T7	Ser210~Ala447 (Accession # Q8CI61)	Inquiry
Mouse	Bag4-1818M	Recombinant Mouse Bag4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	BAG4-8194Z	Recombinant Zebrafish BAG4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
BAG4 Related Articles

BAG4 involved in several pathways and played different roles in them. We selected most pathways BAG4 participated on our site, such as TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
TNF signaling pathway	IKBKG;PIK3R3;NFKB1;CCL20;MAPK9;TNFAIP3;ITCH;CCL5;MMP14

BAG4 has several biochemical functions, for example, chaperone binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAG4 itself. We selected most functions BAG4 had, and list some proteins which have the same functions with BAG4. You can find most of the proteins on our site.

Function	Related Protein
chaperone binding	CXorf41;GNB5;BAX;DNAJA4;SOD1;SYVN1;HSP104;BAG3;PIH1D3
poly(A) RNA binding	MRPS23;SPATS2;DDX28;SNRNP200;PTBP2;GTF2F1;SNTB2;EIF4E;CCAR1
protein binding	EID1;GYPC;MCM4;ACVR1B;BMP1A;CCDC28A;ANKRD49;FAM131C;INCENP
receptor signaling protein activity	DOK1;DOK5;CD3E;cgr2b;KLK1B3;FLRT3;ADCYAP1;ARAF;BAG4
ubiquitin protein ligase binding	NEDD8;FLJ11011L;SQSTM1;UBE2B;LC3;DIO2;CDKN1A;DAXX;DBT

BAG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAG4.

DCP1A; HSPA2; DNAJC7; b3ktt5_human; TET3; HSF2; SIM2; STK11; q53fc7_human; q5c8s5_human; DCP1B; GLCE; LYPD3; DIRAS3

Etokebe, GE; Bulat-Kardum, L; et al. Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis. PLOS ONE 9:-(2014).

Yang, JL; Zhang, W; et al. New molecular insights into osteosarcoma targeted therapy. CURRENT OPINION IN ONCOLOGY 25:398-406(2013).