|Official Full Name||Bardet-Biedl syndrome 2|
|Background||This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with six other BBS proteins.|
|Synonyms||BBS2; Bardet-Biedl syndrome 2; BBS; Bardet-Biedl syndrome 2 protein; Bardet Biedl syndrome 2; Bardet Biedl syndrome 2 protein; MGC20703|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
BBS2 involved in several pathways and played different roles in them. We selected most pathways BBS2 participated on our site, such as Assembly of the primary cilium, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Assembly of the primary cilium||CEP164; SSTR3; CCT2; MKS1; NDE1; IFT22; TCTEX1D1; CEP97; PLK4; CEP290|
|BBSome-mediated cargo-targeting to cilium||CCT5; MKKS; BBS12; BBS1; BBS5; CCT3; BBS2; CCT2; RAB3IP; SETD6|
|Cargo trafficking to the periciliary membrane||BBS4; ARL3; EXOC5; NPHP3; MKKS; EXOC3; TTC8; BBS2; ARL13B; CCT3|
|Organelle biogenesis and maintenance||MRPS36; EXOC3; CCDC123; UNC119.1; MRPL55; EXOC5; BBS13; WDR34; PPRC1; MRPL42|
BBS2 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBS2 itself. We selected most functions BBS2 had, and list some proteins which have the same functions with BBS2. You can find most of the proteins on our site.
|RNA polymerase II repressing transcription factor binding||RBPJ; SIN3A; TTC8; BBS2; STAT3; DMAP1; RBBP8; TCF7L2; TBX5A; GSC|
|protein binding||CEP63; RND3; CCDC68; APOH; CFH; DZIP3; STK4; DPYSL5; RP9; FAM72A|
BBS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBS2.