BCL11B
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Official Full Name
B-cell CLL/lymphoma 11B (zinc finger protein)
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Overview
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013] -
Synonyms
BCL11B; B-cell CLL/lymphoma 11B (zinc finger protein); ATL1; RIT1; CTIP2; CTIP-2; ZNF856B; ATL1-beta; ATL1-alpha; ATL1-delta; ATL1-gamma; hRIT1-alpha; B-cell lymphoma/leukemia 11B; hRit1; BCL-11B; BCL11B/TRDC fusion; B-cell lymphoma/leukaemia 11B; COUP-TF-interacting protein 2; zinc finger protein hRit1 alpha; radiation-induced tumor suppressor gene 1 protein; B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion protein;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | BCL11B-28027TH | Recombinant Human BCL11B, His-tagged | E.coli | His |
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| Human | BCL11B-4875H | Recombinant Human BCL11B protein, His&Myc-tagged | E.coli | His&Myc | 387-823aa |
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| Mouse | BCL11B-2336M | Recombinant Mouse BCL11B Protein | Mammalian Cell | His |
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| Mouse | BCL11B-987M | Recombinant Mouse BCL11B Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Mouse | BCL11B-987M-B | Recombinant Mouse BCL11B Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
BCL11B involved in several pathways and played different roles in them. We selected most pathways BCL11B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL11B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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BCL11B has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL11B itself. We selected most functions BCL11B had, and list some proteins which have the same functions with BCL11B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | TGIF1;ZNF253;POU4F3;E2F8;KLF13;PAX5;SMAD2;DLX4;BSX |
| metal ion binding | AIFM4;ZNF497;AGFG1A;CYP2D9;ZBTB7C;CYP2AD3;ZNF705A;STEAP1;NR1D2B |
| protein binding | P4HB;LIN7A;LGALS8;SNX31;CLN5;EIF4EA;C10orf33;PFN2;ORC3L |
| sequence-specific DNA binding | TSNAX;LMX1A;MAFF;NR1H3;MAFG;FOXB1B;ARGFX;HOXC13B;FOXD1L |
| transcription regulatory region DNA binding | RREB1;FOS;CARM1;JUN;THRA;ARID5A;MEF2C;SALL4;CDK9 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | RBPJ;GLI3;FOXA1;CEBPB;ONECUT2;FOSB;SIX1;MITFB;TFAP4 |
BCL11B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL11B here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL11B.
HDAC1; HDAC2; SUV39H1; HDAC3; AIM2; HDAC6
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