BHMT2
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Official Full Name
betaine--homocysteine S-methyltransferase 2
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Background
Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
BHMT2; betaine--homocysteine S-methyltransferase 2; Betaine homocysteine S methyltransferase 2; EC 2.1.1.5; FLJ20001; betaine-homocysteine methyltransferase 2;
- Involved Pathway
- Protein Function
- Interacting Protein
BHMT2 involved in several pathways and played different roles in them. We selected most pathways BHMT2 participated on our site, such as L-methionine salvage from L-homocysteine, Metabolism, Metabolism of amino acids and derivatives, which may be useful for your reference. Also, other proteins which involved in the same pathway with BHMT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| L-methionine salvage from L-homocysteine | |
| Metabolism | CA5B;SAT1B;CYP3A7-CYP3AP1;PDK4;AZIN1B;ALDH9A1A.2;CYP4F12;DGUOK;AKAP5 |
| Metabolism of amino acids and derivatives | AZIN1A;CTHL;OAZ1;ALDH9A1A.2;FTCD;HIBADH;CDO1;BCKDK;SAT1B |
| Sulfur amino acid metabolism | CDO1;BHMT2;CTHL |
| methionine salvage | |
| superpathway of L-methionine salvage and degradation |
BHMT2 has several biochemical functions, for example, S-adenosylmethionine-homocysteine S-methyltransferase activity, S-methylmethionine-homocysteine S-methyltransferase activity, NOT betaine-homocysteine S-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BHMT2 itself. We selected most functions BHMT2 had, and list some proteins which have the same functions with BHMT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| S-adenosylmethionine-homocysteine S-methyltransferase activity | BHMT2;BHMT |
| S-methylmethionine-homocysteine S-methyltransferase activity | |
| NOT betaine-homocysteine S-methyltransferase activity | |
| zinc ion binding | LHX2B;TXNDC17;UBR7;BHMT;KCMF1;CXXC5;PCGF3;ZDHHC5;TRIM35-34 |
BHMT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BHMT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BHMT2.
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