BIRC5 Protein


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Official Full Name baculoviral IAP repeat containing 5
Background This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Synonyms BIRC5; baculoviral IAP repeat containing 5; API4; EPR-1; baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Mamanlian cells
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • CaM
    • Fc
    • His
    • Flag
    • Gly & Pro
    • GST
    • His-SUMO
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BIRC5-325H Recombinant Human BIRC5 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human BIRC5-047H Recombinant Human BIRC5 Protein E.coli N/A
    Human BIRC5-228H Recombinant Human BIRC5 Protein, GST-tagged Wheat Germ GST
    Human BIRC5-229H Recombinant Human BIRC5 Protein, GST-tagged Wheat Germ GST
    Human BIRC5-31485TH Recombinant Human BIRC5 E.coli N/A
    Human BIRC5-31754TH Recombinant Human BIRC5, His-tagged E.coli His
    Human BIRC5-324H Recombinant Human BIRC5, Gly & Pro tagged E.coli Fc/His
    Human BIRC5-376H Recombinant Human baculoviral IAP repeat-containing 5, CaM-tagged E.coli CaM
    Human BIRC5-4944H Recombinant Human Baculoviral IAP Repeat Containing 5, His-tagged E.coli His
    Human BIRC5-942H Recombinant Human BIRC5 Protein, His-tagged E.coli His
    Rat BIRC5-986R Recombinant Rat BIRC5 Protein Mammalian Cell His
    Cynomolgus Monkey BIRC5-345C Recombinant Cynomolgus BIRC5 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque BIRC5-541R Recombinant Rhesus monkey BIRC5 Protein, His-tagged Mammalian Cell His
    Chicken BIRC5-1891C Recombinant Chicken BIRC5 Mammalian Cell His
    Human BIRC5-8449HCL Recombinant Human BIRC5 293 Cell Lysate HEK293 N/A
    Human BIRC5-097H Recombinant Human BIRC5 Protein, Gly & Pro-tagged E.coli Gly & Pro
    Human BIRC5-1639HF Recombinant Full Length Human BIRC5 Protein, GST-tagged In Vitro Cell Free System GST
    Mouse BIRC5-17M Recombinant Mouse BIRC5 Protein, His-tagged E.coli His
    Human BIRC5-18H Recombinant Human BIRC5 Protein, His-tagged E.coli His
    Human BIRC5-2593H Recombinant Human BIRC5 protein, His-SUMO-tagged E.coli His-SUMO
    Mouse Birc5-2594M Recombinant Mouse Birc5 protein, His-SUMO-tagged E.coli His-SUMO
    Human BIRC5-7313HFL Recombinant Full Length Human BIRC5 protein, Flag-tagged Mamanlian cells Flag
    Human BIRC5-5592H Recombinant Human BIRC5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse BIRC5-1341M Recombinant Mouse BIRC5 Protein (1-140 aa), His-tagged Yeast His
    Mouse Birc5-162M Recombinant Mouse Birc5 Protein, His-tagged E.coli His
    Mouse Birc5-627M Recombinant Mouse Birc5 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    BIRC5 involved in several pathways and played different roles in them. We selected most pathways BIRC5 participated on our site, such as Hippo signaling pathway, Hepatitis B, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hippo signaling pathway TEAD2; BMP5; WNT5A; WWTR1; TEAD3; GLI2; PPP1CA; CRB1; AFP; CTNNA3
    Hepatitis B MAP2K4; CCNA1; CCNA2; IFNA5; PTK2B; CXCL8; CASP9; CASP10; NFATC1; CREB5
    Pathways in cancer GNB3; WNT3A; RUNX1; CSF1R; PRKCA; TFG; STAT3; FGF9; FGF2; MAPK3
    Colorectal cancer TGFB1; PIK3R5; MAPK8; KRAS; PIK3R3; MSH2; PIK3CD; RAC3; AKT2; TGFBR1

    BIRC5 has several biochemical functions, for example, Ran GTPase binding, chaperone binding, cobalt ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC5 itself. We selected most functions BIRC5 had, and list some proteins which have the same functions with BIRC5. You can find most of the proteins on our site.

    Function Related Protein
    Ran GTPase binding CSE1L; NUP153; XPO5; NUTF2; BIRC5; XPO4; IPO13; XPO6; DPY19L2; RANBP1
    chaperone binding UBL4A; UBL4; PACRG; SERPINA7; TBCC; DNAJB4; ATP1A3; AMFR; DNAJC10; CLU
    cobalt ion binding PML; NUDT16; BIRC5; SLC11A2; P2RX2
    cofactor binding UROS; C3; PHYH; ME3; ACLYA; DAO; LMO2; PAH; PGAM2; ASNS
    cysteine-type endopeptidase inhibitor activity BIRC7; PTTG1; CST5; SERPINB3; CARD17; AHSG2; NLRC4; NGP; CST1; BIRC5
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process IGF1RA; MT3; GAS6; PRDX5; LEF1; BIRC7; SERPINB1A; BIRC5; DPEP1; C1QL4L
    enzyme binding BIRC7; DDX5; TGFB1; KDM4C; SCNM1-PS; CYP1A1; DYM; CBX4; POR; HAND1
    identical protein binding VIM; UBE4A; DCTPP1; MUL1; WRNIP1; CSK; MCPH1; CSNK2B; VPS4B; NUDT16
    metal ion binding MDP1; NKD2B; EXT1C; ZRANB3; MOB3A; GNAO1; FAM96A; KLF12B; RHO; CTH1
    microtubule binding TRIM54; KIF18B; PRC1; TRPV4; FMR1; NME8; KIF17; JAKMIP1; MTAP4; CAMSAP2A
    protein binding FKBP5; MAFB; CP110; TRAF4; PPP1R8; SSX1; AHSA2; TNNC2; LRRC3; FAM110C
    protein heterodimerization activity SLC51A; UGT1A6A; TFDP3; HNF1B; RAB3GAP2; GABPA; WHRN; ATF2; CUL3; TLR6
    protein homodimerization activity MTPAP; RAB11FIP4; HPGDS; SYT10; NR0B1; DEM1; CACYBP; IRAK2; ASNSD1; ADD1
    tubulin binding FYN; STMN4L; VBP1; CDK5RAP2; STMN1A; STMN4; PRNP; AGBL5; STMN1; AGBL4
    ubiquitin-protein transferase activity TSPAN17; BRCA1; ITCH; HECTD1; BARD1; PRKCQ; WWP2; RNF182; RNF213; ZNRF1
    zinc ion binding MAN2B2; TRIM68; RNF112; PIAS1; SCEL; RNF113B; PRICKLE2A; LHX2A; ADAMTS13; PDZRN3B

    BIRC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC5.


    Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
    Chen, J; Pise-Masison, CA; et al. Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia. BLOOD 121:2029-2037(2013).

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