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  • Official Full Name

    baculoviral IAP repeat containing 5

  • Overview

    This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
  • Synonyms

    BIRC5; baculoviral IAP repeat containing 5; API4; EPR-1; baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • CaM
  • C
  • His
  • Fc|His
  • Flag
  • Gly
  • Pro
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • mSUMO
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BIRC5-942H Recombinant Human BIRC5 Protein, His-tagged E.coli His 1 - 142
Human BIRC5-376H Recombinant Human baculoviral IAP repeat-containing 5, CaM-tagged E.coli CaM
Human BIRC5-4944H Recombinant Human Baculoviral IAP Repeat Containing 5, His-tagged E.coli His
Human BIRC5-31485TH Recombinant Human BIRC5 protein E.coli N/A Met1-Asp142
Human BIRC5-229H Recombinant Human BIRC5 Protein, GST-tagged Wheat Germ GST
Human BIRC5-047H Recombinant Human BIRC5 Protein E.coli N/A
Human BIRC5-31754TH Recombinant Human BIRC5, His-tagged E.coli His 142 amino acids
Human BIRC5-324H Recombinant Human BIRC5, Gly & Pro tagged E.coli Fc/His
Human BIRC5-325H Recombinant Human BIRC5 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BIRC5-228H Recombinant Human BIRC5 Protein, GST-tagged Wheat Germ GST
Human BIRC5-8449HCL Recombinant Human BIRC5 293 Cell Lysate HEK293 N/A
Human BIRC5-2465H Recombinant Human BIRC5 protein(41-130 aa), N-mSUMO & C-His-tagged E. coli N-mSUMO & C-His 41-130 aa
Human BIRC5-7313HFL Recombinant Full Length Human BIRC5 protein, Flag-tagged Mamanlian cells Flag
Human BIRC5-2593H Recombinant Human BIRC5 protein, His-SUMO-tagged E.coli His-SUMO 1-142aa
Human BIRC5-18H Recombinant Human BIRC5 Protein, His-tagged E.coli His
Human BIRC5-5592H Recombinant Human BIRC5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BIRC5-2464H Recombinant Human BIRC5 protein(41-130 aa), C-His-tagged E. coli C-His 41-130 aa
Human BIRC5-1639HF Recombinant Full Length Human BIRC5 Protein, GST-tagged In Vitro Cell Free System GST 142 amino acids
Human BIRC5-097H Recombinant Human BIRC5 Protein, Gly & Pro-tagged E.coli Gly & Pro Met1-Asp142
Human BIRC5-0717H Recombinant Human BIRC5 Protein (M1-D142), His tagged E.coli His M1-D142
Human BIRC5-0718H Recombinant Human BIRC5 Protein (M1-D142), Tag Free E.coli No tag M1-D142
Mouse Birc5-162M Recombinant Mouse Birc5 Protein, His-tagged E.coli His Met1~Ala140
Mouse BIRC5-17M Recombinant Mouse BIRC5 Protein, His-tagged E.coli His
Mouse Birc5-2594M Recombinant Mouse Birc5 protein, His-SUMO-tagged E.coli His-SUMO 1-140aa
Mouse Birc5-627M Recombinant Mouse Birc5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse BIRC5-1341M Recombinant Mouse BIRC5 Protein (1-140 aa), His-tagged Yeast His 1-140 aa
Rat BIRC5-986R Recombinant Rat BIRC5 Protein Mammalian Cell His
Rat BIRC5-644R Recombinant Rat BIRC5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BIRC5-644R-B Recombinant Rat BIRC5 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey BIRC5-345C Recombinant Cynomolgus BIRC5 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey BIRC5-93C Recombinant Cynomolgus Monkey BIRC5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey BIRC5-93C-B Recombinant Cynomolgus Monkey BIRC5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BIRC5-541R Recombinant Rhesus monkey BIRC5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque BIRC5-369R-B Recombinant Rhesus Macaque BIRC5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BIRC5-369R Recombinant Rhesus Macaque BIRC5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken BIRC5-1891C Recombinant Chicken BIRC5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BIRC5 Related Articles

BIRC5 involved in several pathways and played different roles in them. We selected most pathways BIRC5 participated on our site, such as Hippo signaling pathway, Hepatitis B, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hippo signaling pathwayPPP2R1A;BMP8A;FZD3;BMP7;CCND1;WNT5B;GSK3B;WTIP;FZD6

BIRC5 has several biochemical functions, for example, Ran GTPase binding, chaperone binding, cobalt ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC5 itself. We selected most functions BIRC5 had, and list some proteins which have the same functions with BIRC5. You can find most of the proteins on our site.

Function Related Protein
chaperone bindingPIH1D3;TIMM9;BAG1;TBCA;GNB5;BAG2;TG;UBL4A;TSC1
cobalt ion bindingSLC11A2;BIRC5;PML;NUDT16;P2RX2
cysteine-type endopeptidase inhibitor activityCST11;SPOCK1;SERPINB13;NLRC4;SERPINB3;AHSG2;CTLA2B;CST1;CST7
cysteine-type endopeptidase inhibitor activity involved in apoptotic processBIRC5;BIRC8;SERPINB9;RPS6KA3;TNFAIP8;C1QL4L;NOL3;GAS6;IGF1RA
identical protein bindingCAV1;OMG;ALK;IAPP;PCNA;COL1A2;BNIP3;CEP57L1;PIP4K2C
microtubule bindingRCC2;AKAP1;GABARAP;KIF1C;CDK5RAP2;KIF9;KIFC3;WDR43;KIF16B
protein bindingRUFY4;CDKN2B;CDKAL1;MYCBP;IPO13;ZNF695;TRIM38;TMEM174;LAMA4
protein heterodimerization activityTBX18;MYF6;HIST1H4C;MYH7;IL12A;TCF3A;GTF2A2;TYR;MYOD1
protein homodimerization activityMTHFD1L;DRD2;PRPS2;IRF3;KCNE2;GRPEL1;IZUMO3;CRYBA1;CSF1R
ubiquitin-protein transferase activitySHPRH;SKP1;TRIM62;MUL1;TRIM27;RNF181;TRAF3;MIB2;FBXL14B

BIRC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC5.


Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
Chen, J; Pise-Masison, CA; et al. Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia. BLOOD 121:2029-2037(2013).
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