BIRC5 Protein


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Official Full Name baculoviral IAP repeat containing 5
Background This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Synonyms BIRC5; baculoviral IAP repeat containing 5; API4; EPR-1; baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Mamanlian cells
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • CaM
    • Fc
    • His
    • Flag
    • Gly & Pro
    • GST
    • His-SUMO
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BIRC5-325H Recombinant Human BIRC5 protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human BIRC5-047H Recombinant Human BIRC5 Protein E.coli N/A Inquiry
    Human BIRC5-228H Recombinant Human BIRC5 Protein, GST-tagged Wheat Germ GST Inquiry
    Human BIRC5-229H Recombinant Human BIRC5 Protein, GST-tagged Wheat Germ GST Inquiry
    Human BIRC5-31485TH Recombinant Human BIRC5 E.coli N/A Inquiry
    Human BIRC5-31754TH Recombinant Human BIRC5, His-tagged E.coli His Inquiry
    Human BIRC5-324H Recombinant Human BIRC5, Gly & Pro tagged E.coli Fc/His Inquiry
    Human BIRC5-376H Recombinant Human baculoviral IAP repeat-containing 5, CaM-tagged E.coli CaM Inquiry
    Human BIRC5-4944H Recombinant Human Baculoviral IAP Repeat Containing 5, His-tagged E.coli His Inquiry
    Human BIRC5-942H Recombinant Human BIRC5 Protein, His-tagged E.coli His Inquiry
    Rat BIRC5-986R Recombinant Rat BIRC5 Protein Mammalian Cell His Inquiry
    Cynomolgus Monkey BIRC5-345C Recombinant Cynomolgus BIRC5 Protein, His-tagged Mammalian Cell His Inquiry
    Rhesus Macaque BIRC5-541R Recombinant Rhesus monkey BIRC5 Protein, His-tagged Mammalian Cell His Inquiry
    Chicken BIRC5-1891C Recombinant Chicken BIRC5 Mammalian Cell His Inquiry
    Human BIRC5-8449HCL Recombinant Human BIRC5 293 Cell Lysate HEK293 N/A Inquiry
    Human BIRC5-097H Recombinant Human BIRC5 Protein, Gly & Pro-tagged E.coli Gly & Pro Inquiry
    Human BIRC5-1639HF Recombinant Full Length Human BIRC5 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Mouse BIRC5-17M Recombinant Mouse BIRC5 Protein, His-tagged E.coli His Inquiry
    Human BIRC5-18H Recombinant Human BIRC5 Protein, His-tagged E.coli His Inquiry
    Human BIRC5-2593H Recombinant Human BIRC5 protein, His-SUMO-tagged E.coli His-SUMO Inquiry
    Mouse Birc5-2594M Recombinant Mouse Birc5 protein, His-SUMO-tagged E.coli His-SUMO Inquiry
    Human BIRC5-7313HFL Recombinant Full Length Human BIRC5 protein, Flag-tagged Mamanlian cells Flag Inquiry
    Human BIRC5-5592H Recombinant Human BIRC5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse BIRC5-1341M Recombinant Mouse BIRC5 Protein (1-140 aa), His-tagged Yeast His Inquiry
    Mouse Birc5-162M Recombinant Mouse Birc5 Protein, His-tagged E.coli His Inquiry
    Mouse Birc5-627M Recombinant Mouse Birc5 Protein, MYC/DDK-tagged HEK293T MYC/DDK Inquiry

    BIRC5 involved in several pathways and played different roles in them. We selected most pathways BIRC5 participated on our site, such as Hippo signaling pathway, Hepatitis B, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hippo signaling pathway FZD3; PPP2R2B; STK3; LATS1; GSK3B; BMP2; PPP1CA; CTNNA2; BTRC; SMAD1
    Pathways in cancer LPAR3; AHA-1; VEGFC; EGLN3; GNG11; PRKCB; RALBP1; CCNA1; ERBB2; TRAF4
    Colorectal cancer DCC; TCF7; PIK3CA; MAP2K1; TGFBR2; TP53; RAC3; PIK3R1; PIK3CD; APC2

    BIRC5 has several biochemical functions, for example, Ran GTPase binding, chaperone binding, cobalt ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC5 itself. We selected most functions BIRC5 had, and list some proteins which have the same functions with BIRC5. You can find most of the proteins on our site.

    Function Related Protein
    Ran GTPase binding KPNB1; XPO6; IPO8; XPOT; IPO5; RANBP3; RANBP10; BIRC5; IPO7; XPO7
    chaperone binding DNAJB4; TRP53; SDF2L1; BAG5; TSC1; BAG2; BIRC5; PARK2; CXorf41; TBCA
    cobalt ion binding BIRC5; NUDT16; P2RX2; SLC11A2; PML
    cofactor binding TYMS; BIRC5; ASNS; C3; WWOX; DAO; DDO; PAH; ACLY; TKT
    cysteine-type endopeptidase inhibitor activity AHSG2; WFDC2; BIRC7; CARD16; PTTG1; CSTL1; CTLA2B; SERPINB13; KNG1; CST9L
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process SNCA; PRDX3; BIRC2; SERPINB1A; TFAP2B; MT3; NOL3; CD27; DPEP1; IGF1RB
    enzyme binding UGT1A9; TOP2A; PLCB1; JUND; AXIN2; RYR2; HIST1H2AI; CSF3; RAC1; PRMT1
    identical protein binding GCC2; SMN2; CLDNG; WRNIP1; S100B; GUCY2E; MMP9; PLDN; DVL1; FBLN1
    metal ion binding ROCK2; GART; ARAP3; ZFP93; DNAJA3; RYBPB; PVALB7; ESR2A; KSR1; GM757
    microtubule binding PAFAH1B1A; FAM154A; KIF12; MAP6D1; KIF3B; MAP205; KIF17; SKA2; CAMSAP1A; MAP1LC3B
    protein binding SNRPC; PILRB; PRKCE; SPSB2; S100A2; TRA2B; DDI1; CCDC64B; UBE2L3; GBF1
    protein heterodimerization activity LIFR; HIST1H3C; ATP4A; HIST2H2AA4; PPP3CA; IKBKG; AGTR1A; NR4A1; HMG20B; NPM1
    protein homodimerization activity TIMM10; OSTA; AOC3; G6PD; CRYBA2; BMP7A; Bcl2a1b; MZF1; NDP; BMP2B
    tubulin binding STMN2A; CENPJ; STMN3; STMN1A; MTAP7D3; TTLL4; LRRK2; PARK2; AGBL5; RABGAP1
    ubiquitin-protein transferase activity RNF115; TRAF7; UBE2M; FBXL5; TOPORS; RNF5; UBE2E3; RNF141; HACE1; MARCH6
    zinc ion binding RNF123; TRIM59; DMD; ADAM10A; GATAD2AB; FBXO30; SF3A3; FBXO30A; RABGGTA; MECR

    BIRC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC5.


    Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
    Chen, J; Pise-Masison, CA; et al. Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia. BLOOD 121:2029-2037(2013).

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