BIRC5

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BIRC5

Official Full Name baculoviral IAP repeat containing 5
Background This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Synonyms BIRC5; baculoviral IAP repeat containing 5; API4; EPR-1; baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • CaM
    • Fc
    • His
    • Gly & Pro
    • GST
    • His-SUMO
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BIRC5-097H Recombinant Human BIRC5 Protein, Gly & Pro-tagged E.coli Gly & Pro
    Human BIRC5-2593H Recombinant Human BIRC5 protein, His-SUMO-tagged E.coli His-SUMO
    Mouse Birc5-2594M Recombinant Mouse Birc5 protein, His-SUMO-tagged E.coli His-SUMO
    Human BIRC5-047H Recombinant Human BIRC5 Protein E.coli N/A
    Human BIRC5-228H Recombinant Human BIRC5 Protein, GST-tagged Wheat Germ GST
    Human BIRC5-229H Recombinant Human BIRC5 Protein, GST-tagged Wheat Germ GST
    Human BIRC5-31485TH Recombinant Human BIRC5 E.coli N/A
    Human BIRC5-31754TH Recombinant Human BIRC5, His-tagged E.coli His
    Human BIRC5-324H Recombinant Human BIRC5, Gly & Pro tagged E.coli Fc/His
    Human BIRC5-325H Recombinant Human BIRC5 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human BIRC5-376H Recombinant Human baculoviral IAP repeat-containing 5, CaM-tagged E.coli CaM
    Human BIRC5-4944H Recombinant Human Baculoviral IAP Repeat Containing 5, His-tagged E.coli His
    Human BIRC5-5592H Recombinant Human BIRC5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BIRC5-8449HCL Recombinant Human BIRC5 293 Cell Lysate HEK293 N/A
    Human BIRC5-942H Recombinant Human BIRC5 Protein, His-tagged E.coli His
    Mouse BIRC5-1341M Recombinant Mouse BIRC5 Protein (1-140 aa), His-tagged Yeast His
    Mouse Birc5-162M Recombinant Mouse Birc5 Protein, His-tagged E.coli His
    Mouse Birc5-627M Recombinant Mouse Birc5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat BIRC5-986R Recombinant Rat BIRC5 Protein Mammalian Cell His
    Cynomolgus Monkey BIRC5-345C Recombinant Cynomolgus BIRC5 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque BIRC5-541R Recombinant Rhesus monkey BIRC5 Protein, His-tagged Mammalian Cell His
    Chicken BIRC5-1891C Recombinant Chicken BIRC5 Mammalian Cell His

    BIRC5 involved in several pathways and played different roles in them. We selected most pathways BIRC5 participated on our site, such as Hippo signaling pathway, Hepatitis B, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hippo signaling pathway RASSF1; AFP; ITGB2; GDF7; GLI2; PPP1CB; ACTB; TGFBR2; FZD2; WNT5B
    Hepatitis B DDX3X; NFKB1; PIK3R2; IFNA7; YWHAZ; TGFB3; NFATC4; MAVS; Casp3; ELK1
    Pathways in cancer PIK3R3; TRAF5; AGTR1B; FZD5; PLEKHG5; PTCH1; MAPK9; HDAC2; GNB4; Shh
    Colorectal cancer CASP9; TGFBR2; FOS; MSH3; PIK3R5; Casp3; RHOA; SMAD2; AXIN2; PIK3R1

    BIRC5 has several biochemical functions, for example, Ran GTPase binding, chaperone binding, cobalt ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC5 itself. We selected most functions BIRC5 had, and list some proteins which have the same functions with BIRC5. You can find most of the proteins on our site.

    Function Related Protein
    Ran GTPase binding XPO4; DPY19L2; IPO13; XPO7; RANBP10; NUP153; CSE1L; IPO7; IPO9; RANGRF
    chaperone binding TBCC; AMFR; Alb; GET4; DNAJA2; ATP1A3; DNAJB2; DNAJB1; TIMM44; TSC1
    cobalt ion binding PML; BIRC5; P2RX2; SLC11A2; NUDT16
    cofactor binding HACL1; HIF1AN; C3; PAH; BIRC5; DAO; ACLY; ME3; PGAM2; PHYH
    cysteine-type endopeptidase inhibitor activity CTLA2B; LCN1; NLRC4; BIRC5B; CST4; CARD18; CST3; CST11; CSTL1; SPOCK1
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process BIRC3; RPS6KA1; BIRC7; LEF1; AVP; BIRC2; MT3; BIRC5; ARRB1; DPEP1
    enzyme binding LUC7L2; HIST1H2AI; MSH3; DNMT3L; FOXO4; BACE1; TSPAN14; UGT1A2; AKIRIN2; AXIN1
    identical protein binding PITX2; E2F7; RNF4; AMELX; DACT3; TPD52L1; CD247; CEP57L1; STAC3; NQO1
    metal ion binding DDHD2; SCRT1; DMRT3A; ZNF292A; CYP2C38; ZFP488; CIT; ESCO1; CYGB1; GNAT2
    microtubule binding BIRC5; NDEL1A; CLIP3; APC; RPS3; CNN3; MAP205; HAUS8; KIFC1; MAPRE3
    protein binding UACA; BAIAP2; TBX18; KLHDC4; RAP1GAP; SOCS1; CALM2; CTNND1; TOR1A; PTEN
    protein heterodimerization activity BTBD11; HIST1H2BH; UGT1A9; KCNH1; KCNIP1; ADRA2C; UGT1A4; POLE4; KCNA3; CXorf15
    protein homodimerization activity IKBKB; CR2; CPOX; CTBP2A; SYT6; PLEKHB1; S100A13; CDA; GABPB2; SDCBP2
    tubulin binding LRRK2; ALDOA; TBCA; AGTPBP1; BIRC5; MTAP7D3; TTLL6; PARK2; RITA1; STMN1A
    ubiquitin-protein transferase activity UBE2D2A; MARCH6; WDSUB1; TRIM2; RNF139; HACE1; FBXL6; UBE2W; BRCA1; UBE2E3
    zinc ion binding ZMYM2; PDLIM2; FBXO30A; SUV39H2; TRIM38; PHF1; NR1D2; PITRM1; TRIM43; LTN1

    BIRC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC5.

    INCENP; CDCA8

    Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
    Chen, J; Pise-Masison, CA; et al. Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia. BLOOD 121:2029-2037(2013).

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