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CACNA1H

Official Full Name

calcium channel, voltage-dependent, T type, alpha 1H subunit
Overview

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy. Studies also suggest that the up-regulations of Cav3.2 may participate in the progession of prostate cancer toward an androgen-independent stage.
Synonyms

CACNA1H; calcium channel, voltage-dependent, T type, alpha 1H subunit; voltage-dependent T-type calcium channel subunit alpha-1H; Cav3.2; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; voltage-gated;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
Flag
His|GST

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CACNA1H-26604TH	Recombinant Human CACNA1H, His-tagged	E.coli	His		Inquiry
Human	CACNA1H-1186HFL	Recombinant Human CACNA1H protein, His&Flag-tagged	HEK293	His&Flag	1-2347 aa	Inquiry
Human	CACNA1H-2873H	Recombinant Human CACNA1H protein, His-tagged	E.coli	His	1181-1280 aa	Inquiry
Mouse	Cacna1h-1424M	Recombinant Mouse Cacna1h protein, His & GST-tagged	E.coli	His/GST	Ser2160~Val2359 (Accession # O88427)	Inquiry
Rat	CACNA1H-1064R	Recombinant Rat CACNA1H Protein	Mammalian Cell	His		Inquiry
Rat	CACNA1H-728R	Recombinant Rat CACNA1H Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	CACNA1H-728R-B	Recombinant Rat CACNA1H Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

CACNA1H involved in several pathways and played different roles in them. We selected most pathways CACNA1H participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA1H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	CACNB2A;MAP2K4;FLNC;CACNG1A;GADD45B;RASA1;TNFRSF1A;MAP2K6;BDNF
Calcium signaling pathway	TRHRB;GRM5;ADRB2;BDKRB1;P2RX1;PTGFR;ADCY1B;ATP2B2;GRIN2C
Circadian entrainment	CALM4;GNG3;PER1;PER3;PRKACB;CACNA1H;ADCYAP1R1;CAMK2G;RASD1
Aldosterone synthesis and secretion	CREB3L2;PRKCE;HSD3B5;CACNA1G;SCARB1;Adcy4;DDX1;CYP11A1;NETO2

CACNA1H has several biochemical functions, for example, low voltage-gated calcium channel activity, metal ion binding, scaffold protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA1H itself. We selected most functions CACNA1H had, and list some proteins which have the same functions with CACNA1H. You can find most of the proteins on our site.

Function	Related Protein
low voltage-gated calcium channel activity	CACNA1G;CACNA1H
metal ion binding	OVOL3;CYP2AA1;ZSCAN21;TIPARP;KLF9;ZFP280D;ZFP629;NRAP;ZFP367
scaffold protein binding	KRT18;KCNA5;LRP4;SRC;KRT15;NLGN4Y;GRIN2A;NOS1;CHUK

CACNA1H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA1H here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA1H.

PPP3CB; MAPK15