CACNA2D4

  • Official Full Name

    calcium channel, voltage-dependent, alpha 2/delta subunit 4
  • Overview

    This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
  • Synonyms

    CACNA2D4;calcium channel, voltage-dependent, alpha 2/delta subunit 4;voltage-dependent calcium channel subunit alpha-2/delta-4;voltage-gated calcium channel alpha(2)delta-4 subunit;voltage-gated calcium channel subunit alpha-2/delta-4;RCD4
Cat.# Product name Source (Host) Species Tag Protein Length Price
CACNA2D4-876H Recombinant Human CACNA2D4 Mammalian Cells Human His
CACNA2D4-143HCL Recombinant Human CACNA2D4 lysate HEK293 Human Non
CACNA2D4-2580H Recombinant Human CACNA2D4 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
CACNA2D4-2580H-B Recombinant Human CACNA2D4 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    CACNA2D4 involved in several pathways and played different roles in them. We selected most pathways CACNA2D4 participated on our site, such as MAPK signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA2D4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxytocin signaling pathway MYL9,PIK3R3,CACNG8,PPP3CB,ELK1,CAMK1D,TRPM2,MAPK7,PRKACA,PRKCB
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) CACNA2D2,SGCD,TCF7L2,SLC8A1,ACTG1,CTNNA1,ACTB,Itga10&Itgb1,ITGA6,ITGA2B
    MAPK signaling pathway C11orf52,ARRB2A,TAOK1,MAX,IL1A,RAF1A,PRKACBB,FLNB,NFATC1,DUSP8A
    Hypertrophic cardiomyopathy (HCM) MYL2,ACTC1,MYBPC3,TGFB2,ITGB5,TNNC1,ITGA8,SGCG,PRKAA2,ITGB1
    Adrenergic signaling in cardiomyocytes PPP2R2BB,CACNB3A,ATP1A3A,SLC9A1,ADRa1A,ADRB2A,PPP2R5E,AGTR1,MYH15,VMHCL
    Dilated cardiomyopathy ITGA2B,EMD,Adcy4,SGCB,CACNG4,CACNG3,TNF,ITGA3,LMNA,ACTG1
    Cardiac muscle contraction COX7B2,VMHCL,ATP1B4,TPM1,CACNB3A,CACNB4A,COX6B1,TPM3,CACNB2,TNNT2A

    Protein Function

    CACNA2D4 has several biochemical functions, for example, calcium channel regulator activity,metal ion binding,voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA2D4 itself. We selected most functions CACNA2D4 had, and list some proteins which have the same functions with CACNA2D4. You can find most of the proteins on our site.

    Function Related Protein
    voltage-gated calcium channel activity CATSPER3,CACNA1BA,CACNG8A,TMC1,CACNB4B,TPC3,TPCN2,CACNA1C,CACNG2A,CACNB2B
    metal ion binding ZFP687,ZMIZ2,NUPL2,ZNF295,ZNF461,SCRT1B,ACLYA,COPS5,INSM2,COL27A1
    calcium channel regulator activity GRM6A,CACNB2,STIM1A,GRM7,STIM1,TMEM110,CRISP1,TSPAN13A,NRXN3,TSPAN13B

    Interacting Protein

    CACNA2D4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA2D4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA2D4.

    Resources

    References

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