cacnb4 Protein, Calcium Channel, Voltage-Dependent, Beta 4 Subunit


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Official Full Name Calcium Channel, Voltage-Dependent, Beta 4 Subunit
Background Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. Specifically, this gene encodes a member of the β subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of α1, α3/δ, β, andγ subunits in a 1:1:1:1 ratio. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling theα1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
Synonyms CACNB4; Cavβ4 Calcium Channel; EA5; EJM; calcium channel, voltage-dependent, beta 4 subunit; CAB4; EIG9; EJM4; EJM6; CACNLB4; voltage-dependent L-type calcium channel subunit beta-4; calcium channel voltage-dependent subunit beta 4; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; OTTHUMP00000207228; OTTHUMP00000207246; OTTHUMP00000207247; OTTHUMP00000207248; OTTHUMP00000207249; OTTHUMP00000209460
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CACNB4-056H Recombinant Human CACNB4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Cacnb4-738M Recombinant Mouse Cacnb4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CACNB4-0274H Recombinant Human CACNB4 Protein, GST-Tagged Wheat Germ GST
    Human CACNB4-10640H Recombinant Human CACNB4, His-tagged E.coli His
    Human CACNB4-7902HCL Recombinant Human CACNB4 293 Cell Lysate HEK293 N/A
    Rhesus Macaque CACNB4-603R Recombinant Rhesus monkey CACNB4 Protein, His-tagged Mammalian Cell His
    Chicken CACNB4-1136C Recombinant Chicken CACNB4 Mammalian Cell His
    Chicken CACNB4-5916C Recombinant Chicken CACNB4 Mammalian Cell His

    cacnb4 involved in several pathways and played different roles in them. We selected most pathways cacnb4 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with cacnb4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAP4K4; ZAK; FASLG; PPP3R1; PPM1AA; MAPT; NTF3; MAP2K3; MAP3K1; GADD45BB
    Cardiac muscle contraction ACTC1; COX7A2L; MYH7; TPM3; COX5A; CACNA2D3; COX8C; COX6A1; COX4I2; ATP1A3
    Adrenergic signaling in cardiomyocytes GNAS; PPP2R2CA; PPP1CC; ATP2B3B; PPP2R2BB; ATP1B1B; VMHC; ATP1B3A; CALML3; GNAI1
    Oxytocin signaling pathway HRAS; PPP1CB; MYLK; CAMK2D; PTGS2; CAMK2B; GUCY1B3; PRKCA; NRAS; PRKAB2
    Hypertrophic cardiomyopathy (HCM) ITGB1; SGCA; CACNB3; SGCB; ACTG1; TPM4; ITGB8; ITGA7; CACNA2D2; PRKAG2
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) CACNG2; GJA1; ITGA9; ITGA10; CACNG7; DES; LAMA2; SGCA; DMD; ACTB
    Dilated cardiomyopathy ITGB8; TGFB1; ITGB5; PLN; ITGA1; RYR2; TGFB3; CACNB1; ATP2A2; SGCG

    cacnb4 has several biochemical functions, for example, contributes_to high voltage-gated calcium channel activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cacnb4 itself. We selected most functions cacnb4 had, and list some proteins which have the same functions with cacnb4. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to high voltage-gated calcium channel activity CACNB2; CACNB4
    protein binding AIP; AIRE; P4HB; TMEM74; TRIM43; KAT2B; WBP1; SYCE3; PTPRS; UBL5
    protein kinase binding CAMK2N1; LSM2; TTN; FAM83E; RFFL; STAP1; LAT; ADCY6; DNM1; MS4A2
    contributes_to voltage-gated calcium channel activity CACNA2D1; CACNB3; CACNB4

    cacnb4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cacnb4 here. Most of them are supplied by our site. Hope this information will be useful for your research of cacnb4.


    Billings, SE; Clarke, GL; et al. ELKS1 and Ca2+ channel subunit beta 4 interact and colocalize at cerebellar synapses. NEUROREPORT 23:49-54(2012).
    Fahanik-babaei, J; Eliassi, A; et al. Electro-pharmacological profile of a mitochondrial inner membrane big-potassium channel from rat brain. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1808:454-460(2011).

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