cblc
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  • Official Full Name
  • Cbl proto-oncogene, E3 ubiquitin protein ligase C
  • Background
  • This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell;signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be;restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been;observed for this gene.
  • Synonyms
  • CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas Br M (murine) ecotropic retroviral transforming sequence c , Cas Br M (murine) ectropic retroviral transforming sequence c; signal transduction protein CBL-C; CBL 3; CBL SL; RNF57; RING finger
Cat.#:CBLC-0461HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CBLC Protein, GST-Tagged
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Cat.#:CBLC-2725HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CBLC Protein, MYC/DDK-tagged
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Cat.#:CBLC-10757HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CBLC, His-tagged
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Cat.#:CBLC-442HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CBLC, His-GST tagged
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Cat.#:CBLC-6818ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CBLC
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Cat.#:CBLC-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CBLC cell lysate
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Involved Pathway

CBLC involved in several pathways and played different roles in them. We selected most pathways CBLC participated on our site, such as ErbB signaling pathway, Ubiquitin mediated proteolysis, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBLC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
CDKN1BB; GRB2B; PLCG1; HRAS; MAP2K2; PIK3R3; PAK3; NCK2; GSK3B; MAPK9
Ubiquitin mediated proteolysis
UBE2K; UBE2D1; SIAH1; PARK2; PRP19; TRAF6; MID1; TCEB2; UBE2NB; UBE2Q1
Endocytosis
RAB11FIP3; ACAP3; RAB5AB; SH3GL1B; CAV1; KITB; SH3GLB2; RAB11AL; MVB12A; IQSEC1
T cell receptor signaling pathway
CD8B; PAK7; Il2; PPP3CC; PDPK1; CD247; AKT2; RHOA; NFKBIB; MAP2K1
Insulin signaling pathway
PTPN1; FBP1B; PPP1R3D; NRAS; PYGM; PHKG1B; PDPK1B; PPARGC1A; CBL; PHKB
Bacterial invasion of epithelial cells
ARPC2; PIK3CG; CTNNA1; CLTA; ARPC3; SEPT11; ACTG1; WAS; ELMO1; ITGA5
Pathways in cancer
FGF6; PDGFRA; CDH1; PRKCB; MAPK1; WNT10B; WNT9B; TGFA; MSH3; PPARG
Proteoglycans in cancer
HRAS; HIF1A; ITPR1; WNT11; SDC2; ITGA2; MAPK11; WNT2B; PRKACB; PRKCA
Chronic myeloid leukemia
CRK; MDM2; TP53; NFKB1; CBLC; IKBKG; CBLB; TRP53; BRAF; PIK3CA

Protein Function

CBLC has several biochemical functions, for example, SH3 domain binding, calcium ion binding, epidermal growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBLC itself. We selected most functions CBLC had, and list some proteins which have the same functions with CBLC. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein DRD4; NOXA1; SKAP1; AFAP1L2; ARHGAP6; SH3BGR; HCLS1; ITM2B; USP8; ERRFI1
Function calcium ion binding
Related Protein RYR3; PVALB1; PLCB1; MAN1C1; ANXA3A; C2CD4B; PKD2L1; MBL1; SYT9B; VCANB
Function epidermal growth factor receptor binding
Related Protein MS4A1; SNX4; RNF126; FAM83B; SOCS5; BTC; EPGN; VAV3; SHC1; HBEGFA
Function ligase activity
Related Protein MIB2; TTLL6; TRIM32; RNF19B; SH3RF2; MKRN1; RNF40; UFL1; BRCA1; UCHL1
Function phosphotyrosine binding
Related Protein CBL; STAP1; MAPK3; LDLRAP1; MAPK1; CBLC; FGR; SHC1; GRB2; PTPN3
Function signal transducer activity
Related Protein NPFFR1L1; OPN4XA; GPR89; OLFCS2; COPS2; TAAR11; PPM1A; TRIM54; TAAR14J; TAAR14F
Function ubiquitin protein ligase activity
Related Protein MED1; SMURF1; HECTD2; TRIM11; RBX1; RNF19B; MED17; RNF25; PPIL2; CDK8
Function zinc ion binding
Related Protein TRIM21; RNF128A; AKT1S1; PHF21B; USP5; NR2F6B; ZDHHC22; POLR2L; ADH5; UBR3

Interacting Protein

CBLC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBLC here. Most of them are supplied by our site. Hope this information will be useful for your research of CBLC.
ITCH; CRK; ABI1; HIP2; UBE2L6; NACAD; SHC1; UBE2H; UBE2I; UBE2L3; BIRC2; OXA1L; UBE2R2; TRIM46; recN