CBLC

  • Official Full Name

    Cbl proto-oncogene, E3 ubiquitin protein ligase C

  • Overview

    This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell;signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be;restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been;observed for this gene.

  • Synonyms

    CBLC;Cbl proto-oncogene, E3 ubiquitin protein ligase C;Cas Br M (murine) ecotropic retroviral transforming sequence c , Cas Br M (murine) ectropic retroviral transforming sequence c;signal transduction protein CBL-C;CBL 3;CBL SL;RNF57;RING finger

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Wheat Germ
  • Insect Cells
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Fc
  • Non
  • DDK
  • Myc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
CBLC-10757H Recombinant Human CBLC, His-tagged E.coli Human His N-term-350a.a.
CBLC-0461H Recombinant Human CBLC Protein, GST-Tagged Wheat Germ Human GST
CBLC-442H Recombinant Human CBLC, His-GST tagged Insect Cells Human Fc 1-474 a.a.
CBLC-6818Z Recombinant Zebrafish CBLC Mammalian Cells Zebrafish His
CBLC-001HCL Recombinant Human CBLC cell lysate Insect Cells Human Non
CBLC-1512H Recombinant Human CBLC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Cblc-1975M Recombinant Mouse Cblc Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
CBLC-2206H Recombinant Human CBLC protein, His&GST-tagged Insect Cells Human GST&His Met1-Ala474
CBLC-2725H Recombinant Human CBLC Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
CBLC-2768HF Recombinant Full Length Human CBLC Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 474 amino acids
CBLC-443H Recombinant Human CBLC Protein, FLAG-tagged HEK293 Human Flag 11-404 a.a.

    Involved Pathway

    CBLC involved in several pathways and played different roles in them. We selected most pathways CBLC participated on our site, such as ErbB signaling pathway,Ubiquitin mediated proteolysis,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBLC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis SNX12,SMAD2,RAB11B,IGF2R,CSF1R,PARD6GA,PARD6B,CHMP4A,MHC1UXA2,LDLRA
    Ubiquitin mediated proteolysis RNF7,CBLB,UBE2G1B,UBE2D4,SMURF2,NEDD4L,MAP3K1,PIAS4B,UBE2IB,BIRC7
    Bacterial invasion of epithelial cells VCL,SEPT9,ARPC1B,RAC1,SEPT6,CDH1,PXN,WASF1,ELMO2,ELMO1
    ErbB signaling pathway PRKCA,AREG,AKT2,MAPK3,ERBB3B,PTK2AB,PIK3R1,NRG2,BAD,SRC
    Pathways in cancer FGF18,CASP9,WNT5B,MTOR,LAMA2,FH1,ERBB2,FZD7,PLEKHG5,DAPK2
    Proteoglycans in cancer CBL,CD63,SOS1,PTPN11,HGF,DROSHA,MDM2,FN1,ERBB4,PLCE1
    Insulin signaling pathway INS,MAPK8B,PRKAR2B,LIPE,FLOT1A,PTPRFB,PCK2,TRIP10,INS1,NRAS
    Chronic myeloid leukemia TGFB2,MAP2K2,MAPK1,ARAF,HDAC1,AKT1,CBL,PIK3R5,PIK3R2,MDM2
    T cell receptor signaling pathway CD4,CARD11,KRAS,DEF6A,MAPK12,PIK3R1,MAPK1,PPP3CC,MAP2K7,GRAP2

    Protein Function

    CBLC has several biochemical functions, for example, SH3 domain binding,calcium ion binding,epidermal growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBLC itself. We selected most functions CBLC had, and list some proteins which have the same functions with CBLC. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity TRIM24,TRIM50,CTPS1A,MARCH8,PCXA,RNF181,TRIM22,UBE2IA,UCHL1,TRIM9
    zinc ion binding ADAMTSL5,ZDHHC4,PIAS2,ZFP346,ZCCHC6,BRF1B,S100A7,MICALL1,TLL1,PDZRN4
    signal transducer activity CBL,OLFR186,MTNR1C,TICAM2,TACR1B,DRD4A,ECM1,PLCD1A,OLFR488,TAS2R103
    phosphotyrosine binding LDLRAP1,ZAP70,ACP2,SHC1,GRB2,MAPK3,STAP1,SAMSN1,FGR,CBLB
    SH3 domain binding PLSCR4,DOCK1,PTPN22,MYPN,GPX1,INPP5D,ARHGAP1,FUT8,ELMO2,SH3BGRL2
    calcium ion binding PCDH17,SYT17,PCDH2AB9,MAN1A1,S100A7,SMOC1,TPD52,REPS1,SPOCK1,SRI
    epidermal growth factor receptor binding ARF4,RNF126,MS4A1,AGR2,TNK2,EPGN,FAM83B,SNX2,EGF,HBEGFB
    ubiquitin protein ligase activity UBE2G1A,PARK2,MED31,CBL,CDC34,UBR1,TRIM71,FBXW11,C18orf25,SIAH2

    Interacting Protein

    CBLC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBLC here. Most of them are supplied by our site. Hope this information will be useful for your research of CBLC.

    ITCH;CRK;ABI1;HIP2;UBE2L6;NACAD;SHC1;UBE2H;UBE2I;UBE2L3;BIRC2;OXA1L;UBE2R2;TRIM46;recN

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