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CBX8

  • Official Full Name

    chromobox homolog 8

  • Overview

    The family of Heterochromatin Proteins ("Chromobox Homolog", CBX) are highly conserved adapter molecules,Which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromere, sequesteration of genes to nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at single nucleosome level and gene repression by heterochromatization of euchromatin.
  • Synonyms

    CBX8; chromobox homolog 8; chromobox homolog 8 (Drosophila Pc class); chromobox protein homolog 8; HPC3; Pc class 3 homolog (Drosophila); PC3; polycomb 3; RC1; rectachrome 1; Pc class 3 homolog; chromobox homolog 8 (Pc class homolog, Drosophila);
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CBX8-0486H Recombinant Human CBX8 Protein, GST-Tagged Wheat Germ GST
Human CBX8-7800HCL Recombinant Human CBX8 293 Cell Lysate HEK293 N/A
Human CBX8-371H Recombinant Human CBX8 protein, His&Myc-tagged E.coli His&Myc 1-389aa
Human CBX8-2784HF Recombinant Full Length Human CBX8 Protein, GST-tagged In Vitro Cell Free System GST 389 amino acids
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CBX8 involved in several pathways and played different roles in them. We selected most pathways CBX8 participated on our site, such as Cellular Senescence, Cellular responses to stress, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBX8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular SenescenceIGFBP7;LMNB1;HIST1H1D;CEBPB;HMGA1;CBX6A;PHC1;PHC2;H3F3D
Cellular responses to stressSUZ12A;IGFBP7;EGLN1B;DNAJC2;HIF1AL;WIPI1;CABIN1;WDR45L;CBX6
Metabolism of proteinsNAT8;ADAMTS10;LMCD1;SLC30A8;CGB7;NSFB;FKBP9;DMBT1;TIMM50
Oxidative Stress Induced SenescenceSUZ12A;PHC2;RNF2;RING1;CBX8B;EED;TNIK;CBX6A;CBX8A
Post-translational protein modificationEIF5A2;TRAPPC4;ADAMTS18;ADAMTSL1;MUC20;EIF5A;ADAMTSL3;GCNT3;TRAPPC10
SUMO E3 ligases SUMOylate target proteinsSMC5;PHC1;CBX4;NSMCE4A;PHC3;RNF2;NSMCE1;SMC6;EID3
SUMOylationNSMCE4A;SMC5;SAE1;NSMCE1;SENP5;SMC6;SENP1;CBX8;PHC3
SUMOylation of DNA damage response and repair proteinsRNF2;PHC2;NSMCE1;NSMCE4A;NSMCE2;SMC5;SCMH1;EID3;PHC1

CBX8 has several biochemical functions, for example, methylated histone binding, protein binding, single-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBX8 itself. We selected most functions CBX8 had, and list some proteins which have the same functions with CBX8. You can find most of the proteins on our site.

Function Related Protein
methylated histone bindingMSH6;MSL3;L3MBTL2;ING1;CHD8;LOXL2;GLYR1;KDM4A;CAPNS2
protein bindingKRIT1;PHB2;FTSJ3;HIST3H3;FBXO6;S100A13;STX4;SCN11A;WIF1
single-stranded RNA bindingSTRBP;DLX2;LSM14A;TLR7;POLR2GL;POLR2G;JMJD6;CBX8;IFIT5
ubiquitin-protein transferase activator activityFBXW7;UBE2L3;AUP1;RING1;CBX8

CBX8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBX8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBX8.

BMI1; RNF2

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