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Official Full Name coiled-coil domain containing 6
Background This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.
Synonyms CCDC6; coiled-coil domain containing 6; D10S170, DNA segment on chromosome 10 (unique) 170 , TST1; coiled-coil domain-containing protein 6; DNA segment; single copy; probe pH4 (transforming sequence; thyroid 1; H4; PTC; TPC; papillary thyroid carcinoma-e
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCDC6-0563H Recombinant Human CCDC6 Protein, GST-Tagged Wheat Germ GST
    Human CCDC6-297HCL Recombinant Human CCDC6 cell lysate N/A
    Mouse CCDC6-2909M Recombinant Mouse CCDC6 Protein Mammalian Cell His
    Chicken CCDC6-2883C Recombinant Chicken CCDC6 Mammalian Cell His

    ccdc6 involved in several pathways and played different roles in them. We selected most pathways ccdc6 participated on our site, such as Pathways in cancer, Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ccdc6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathways in cancer VHL; ITGA3; GNB1; WNT10B; TRP53; PTCH1; SUFU; MLH1; APC2; WNT8B
    Thyroid cancer NCOA4; HRAS; PAX8; CCDC6; RXRA; MAPK1; RET; TRP53; NTRK1; KRAS

    ccdc6 has several biochemical functions, for example, SH3 domain binding, protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by ccdc6 itself. We selected most functions ccdc6 had, and list some proteins which have the same functions with ccdc6. You can find most of the proteins on our site.

    Function Related Protein
    SH3 domain binding RAD9A; FMNL3; FAM125A; OSTF1; INPPL1; ARHGAP27; SKAP1; ILK; KHDRBS3; PLSCR3
    protein binding NAPG; UBE2R2; SRGN; FZD5; BCAP31; DDX19A; PRKAR1A; RCC1; KRT6A; LPHN1
    structural constituent of cytoskeleton BICD1; TUBGCP3; TUBB; TUBB6; DMD; ADD3; INA; TUBA1A; KRT15; SPRR2A1

    ccdc6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ccdc6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ccdc6.

    PPP4C; FBXW7; saicar; PKM; CSNK2A1; USP7; ESR1; P4HB; BMH1; PPP2R1A

    Werner-Peterson, R; Sloboda, RD; et al. Methylation of Structural Components of the Axoneme Occurs During Flagellar Disassembly. BIOCHEMISTRY 52:8501-8509(2013).
    Tang, XQ; Diao, J; et al. Identification of a 37.6 kDa membrane protein from flounder gill cells involved in binding and infection to lymphocystis disease virus. AQUACULTURE 358:132-138(2012).

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