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Official Full Name chaperonin containing TCP1, subunit 6A (zeta 1)
Background The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located.
Synonyms CCT6A; chaperonin containing TCP1, subunit 6A (zeta 1); CCT6; T-complex protein 1 subunit zeta; Cctz; HTR3; TCP20; TCPZ; TTCP20; Amino acid transport defect complementing; CCT zeta 1; CCT zeta; Chaperonin containing T complex subunit 6; Chaperonin containing TCP1 subunit 6A; Chaperonin containing TCP1 subunit 6A (zeta 1); Histidine transport regulator 3; MGC126214; MGC126215; MoDP 2; MoDP2; T complex protein 1 subunit zeta; T complex protein 1 zeta subunit; TCP 1 zeta; TCP1 zeta; T-complex protein 1, zeta subunit; amino acid transport defect-complementing; chaperonin containing T-complex subunit 6; acute morphine dependence-related protein 2; MoDP-2; CCT-zeta; CCT-zeta-1; TCP-1-zeta
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCT6A-0715H Recombinant Human CCT6A Protein, GST-Tagged Wheat Germ GST
    Human CCT6A-173HCL Recombinant Human CCT6A lysate HEK293 N/A
    Human CCT6A-2124H Recombinant Human CCT6A Protein (2-531 aa), His-tagged E.coli His
    Human CCT6A-3011H Recombinant Human CCT6A Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse CCT6A-3027M Recombinant Mouse CCT6A Protein Mammalian Cell His
    Mouse Cct6a-806M Recombinant Mouse Cct6a Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Chicken CCT6A-1364C Recombinant Chicken CCT6A Mammalian Cell His
    Zebrafish CCT6A-11438Z Recombinant Zebrafish CCT6A Mammalian Cell His

    CCT6A involved in several pathways and played different roles in them. We selected most pathways CCT6A participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Association of TriC/CCT with target proteins during biosynthesis CCT5; FKBP9; FBXL5; FBXW9; CCT3; CCT7; CCT6A; TCP1; NOP56; CCT2
    Chaperonin-mediated protein folding PFDN6; PFDN1; TUBA3D; PFDN2; TCP1; CCT8; VBP1; PFDN5; FBXW5; PFDN4
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding TUBA3D; TUBB4B; CCT6A; TUBA1B; PFDN6; PFDN4; CCT4; CCT8; TCP1; PFDN5
    Folding of actin by CCT/TriC CCT4; CCT3; CCT6A; CCT8; CCT2; CCT5; TCP1; CCT7
    Formation of tubulin folding intermediates by CCT/TriC TCP1; CCT8; CCT7; TUBB4A; TUBA3D; CCT3; TUBA1B; CCT4; TUBB4B; CCT2
    Metabolism of proteins TIMM17B; ADAMTSL5; TRAPPC6BL; TRAPPC5; DAD1; PHC3; TIMM17A; SFTPBB; SENP5; TRAPPC9
    Prefoldin mediated transfer of substrate to CCT/TriC PFDN4; CCT6A; PFDN1; PFDN6; CCT7; VBP1; PFDN2; PFDN5
    Protein folding PFDN2; FKBP9; TBCB; FBXW4; PFDN6; FBXL5; TBCC; ARL2; VBP1; NOP56

    CCT6A has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT6A itself. We selected most functions CCT6A had, and list some proteins which have the same functions with CCT6A. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding IFIT2; RPL14; KIAA1324; PNO1; C14orf166; LSM8; ZNF346; MKRN1; XRN2; NOL10
    protein binding NDRG1; KIF3B; TTI1; STRADB; FAM115A; PPP1CC; POLH; GTPBP2; PPIAL4A; CDC34
    unfolded protein binding SCG5; ERLEC1; HTRA2; CALR3B; MKKS; CLPXA; PPIB; HSPA1L; HSPA1A; CLPX

    CCT6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT6A here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT6A.


    Ferguson, JF; Meyer, NJ; et al. Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans. HUMAN MOLECULAR GENETICS 24:1801-1812(2015).
    Wei, QQ; Zhu, GY; et al. Expression of CCT6A mRNA in chicken granulosa cells is regulated by progesterone. GENERAL AND COMPARATIVE ENDOCRINOLOGY 189:15-23(2013).

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